Let’s take a look at the benefits of biotin and zinc for your hair and overall well-being. Benefits of Biotin Although biotin and zinc aren’t considered hair loss treatments, they may contribute to healthy hair growth. Men with hair loss have been shown to have low or subnormal levels of zinc and biotin compared to men without male pattern hair loss. A review article on zinc in patients with AA showed that four of the six case–control studies found low zinc levels in patients with AA as compared to healthy control groups [ 55]. One of these case–control studies was conducted by Kil et al. and included patients with MPHL, FPHL, and TE. The results of this study showed a strong correlation between zinc deficiency (< 70µg/dL) and hair loss [ 124]. Another study found a strong association between zinc deficiency and AA severity and chronicity [ 126]. However, in contrast to these studies, there are two case–control studies carried out in Iran [ 111] and Finland [ 113] that showed no significant correlation between zinc level and AA compared to the controls.

Biotin and Zinc: What You Need to Know - Particle

Practitioners should be aware that biotin requirements may increase during anticonvulsant therapy. [16]In biotinidase deficiency, patient therapy typically consists of lifelong doses of biotin. Biotin doses in the range of 5 to 20 mg can treat and prevent clinical signs and biotinidase deficiency symptoms. [7] [17]The expert formulation in the SuperSelf biotin supplement tablets has been designed to promote healthy hair, skin and nails. Using high-quality ingredients, it delivers a daily dose of 10,000mcg of biotin and 10mg of zinc. Each tablet contains a full daily dose and is odourless and easy to swallow. Suitable for vegetarians and vegans. Zinc is an essential trace element, which means that the body cannot generate it on its own; it must be supplied through the diet. The main dietary sources of zinc are fish and meat. Zinc deficiency can occur in patients consuming large amounts of cereal grain (which contains a phytate considered to be chelating agent of zinc), in those with poor meat consumption or TPN, and in infants on milk formula. Other causes of zinc deficiency include anorexia nervosa (secondary to inadequate intake, increased zinc excretion, and malabsorption due to laxative abuse), inflammatory bowel disease, jejunal bypass surgery, and cystic fibrosis. Alcoholism, malignancy, burns, infection, and pregnancy may all cause increased metabolism and excretion of zinc. As observed in swine, initial clinical symptoms of acquired biotin deficiency include gradual onset of hair loss, dry skin, and lesions on the feet and legs after six months of biotin deficiency. [4] After nine months, the clinical picture resembles a characteristic cutaneous lesion of biotin deficiency. After 3 to 4 weeks of having a raw egg diet in adult humans, desquamative dermatitis was observed. After five weeks, anorexia, lethargy, and hyperaesthesia developed. Administration of biotin relieved symptoms in 5 days. Infants may initially show mild scaly erythema and dermatitis on the face, particularly malar prominences, which may resemble dermatitis rash due to soaps.Holocarboxylase synthetase deficiencycan present very early in fetal life in the form of abnormal CNS findings and intrauterine growth retardation. [29]

biotin supplements for hair and nails in the UK Best biotin supplements for hair and nails in the UK

Research shows that both biotin and zinc contribute to healthy hair and skin. A potent supplement can give your body a boost of these beneficial nutrients. Low Biotin levels can occur in patients on antiepileptics such as carbamazepine, phenytoin, and phenobarbital.Possible underlying mechanisms include impaired biotin uptake across the intestinal mucosa, exaggerated biotin catabolism, and inhibition ofrenal reabsorption. Therefore, patients who are likely to be on anticonvulsants for long periods should receive biotin supplementation. [10] [11] Oral biotin supplements have high bioavailability. Usually, a dose of 5 mg/day is given regardless of the etiology of biotin deficiency. [5]The Food and Nutrition Board of the National Research Council recommends a range of 5 mcg/day in newborn infants to 35 mcg/day in lactating women.

Biotin(vitamin H or vitamin B7) is a B-complex vitaminthat acts as an essential coenzymefor five carboxylases: pyruvate carboxylase, 3-methylcrotonyl-CoA carboxylase, propionyl-CoA carboxylase, and coenzyme for acetyl-CoA carboxylases 1 and 2. [1] [2] [3] [4] These carboxylases help in several chemical processes in the cell, including gluconeogenesis, amino acid metabolism, and fatty acid synthesis. [1] [3] The Food and Nutrition Board of the Institute of Medicine recommends a daily dietary intake of 30 mcg/day to maintain good health. Biotin deficiency is very rare in those who take in a normal balanced diet. Mammals obtain biotin from food. Foods rich in biotin are egg yolk, liver, cereals (wheat, oats), vegetables (spinach, mushrooms), and rice. Dairy items and breast milk also contain biotin. A great head of hair can make a huge difference in your appearance. Taking care of your body, skin, and hair goes hand in hand.

Biotin-Rich Foods - Healthline The Top 10 Biotin-Rich Foods - Healthline

Biotinidase deficiency confirmation is done by DNA analysis, either allele-targeted methods or full-gene sequencing. Currently, all newborn screening programs in the U.S. and more than 30 other countries carry out screening for biotinidase deficiency. [6] [7] [30] [7] If your goal is healthier skin, hair, or nails, a biotin supplement or gummie may help. For best results, eat a nutritious diet with plenty of fruits and vegetables and take vitamin supplements, including biotin, for better overall health. Benefits of ZincResearch shows that biotin (also known as vitamin B7) is a key hair vitamin. As well as contributing to normal hair and skin, biotin also contributes to normal metabolism functioning. Carefully chosen to work together, zinc complements biotin as it also contributes to normal hair and skin. This essential mineral also contributes to the normal function of the immune system, metabolism and healthy nails. Formulated for hair, skin and nails Because vitamin A is stored in our bodies, excessive quantities can be toxic, so be careful to not overdo vitamin A intake. The recommended daily allowance (RDA) is 900 micrograms daily for men and 700 micrograms daily for women. About one cup of raw carrots provides 900 mcg. To maximize your vitamin A potential, eat a well-rounded diet and include plenty of fruits and vegetables, along with dairy products, fish, liver, and fortified cereals. Vitamin C A 1-ounce (28-gram) serving of roasted peanuts contains just under 5 mcg of biotin, or 17% of the DV ( 8). Approximately 20 caps (120 grams) of canned button mushrooms contain 2.6 mcg of biotin, which is nearly 10% of the DV ( 8). Vitamin A represents a group of fat-soluble retinoids that includes retinol, retinal, and retinyl esters [ 11, 12]. This vitamin serves many roles in the body: it is critical for vision, involved in immune function, and is necessary for cellular growth and differentiation [ 13]. Vitamin A exists in the diet as preformed vitamin A (from animal sources) and as provitamin A carotenoids (sourced from plants). Both sources of vitamin A must be metabolized intracellularly to their active forms (retinal and retinoic acid). The majority of vitamin A is stored in the liver as retinyl esters. When measuring retinol and carotenoid levels, plasma levels are typically sufficient for determining adequacy. A plasma retinol concentration of < 0.70 μmol/L signifies vitamin A inadequacy [ 13].

Four Nutrients for Hair, Nails and Skin Health – Food Insight

Eating a healthy, balanced diet and taking a zinc supplement is your best bet to ensure you’re getting adequate amounts of zinc for optimal health. Biotin and Zinc for Hair Health As a general rule, consuming too much or over-supplementing vitamin A can cause hair loss [ 15, 16]. Typically, fat-soluble vitamin A is stored in the liver where its dispersal is tightly regulated by anabolic and catabolic reactions between the inactive and active metabolite. When levels of vitamin A are too high, the capacity of the transport system is exceeded and vitamin A spills over into the circulation [ 17]. Maintaining homeostasis—and by extension the proper concentration of active metabolite—is important for healthy hair [ 18]. While signs of biotin deficiency include hair loss, skin rashes, and brittle nails, the efficacy of biotin in supplements for hair, skin, and nails as a means to remedy these conditions is not supported in large-scale studies [ 25, 26]. In fact, only case reports have been used to justify the use of biotin supplements for hair growth. These case reports were in children and found that 3–5mg biotin daily could improve hair health after 3–4months in children with uncombable hair syndrome [ 37, 38].Biotin (B7) has a key role in cellular energy metabolism, including ATP production and regulation of oxidative stress, since it is a crucial cofactor for five carboxylases that works for mitochondrial metabolism of glucose, fatty acids, and amino acids. Holocarboxylase synthetase plays a vital role in protein biotinylation, and protein biotinidase is essential for the release of biotin from biotinylated peptides. [1] [2] [19] Although a relationship between vitamin D levels and AGA or TE is still being debated, most authors agree in supplementing vitamin D in patients with hair loss and vitamin D deficiency. Vitamin C intake is crucial in patients with hair loss associated with iron deficiency. There are no data to support the role of vitamin E in AGA or TE. Acquired biotin deficiency can be due to increased raw egg consumption, where avidin particles attach to biotin and inhibit its absorption into the intestinal gut. In cooked eggs the avidin particles are destroyed [ 35]. Other causes of acquired biotin deficiency include states of malabsorption, alcoholism, pregnancy, prolonged use of antibiotics that interrupt normal flora, medications such as valproic acid, and isotretinoin intake. The aforementioned medications interfere with biotinidase activity [ 34]. Evidence suggests that 50% of pregnant women are deficient in biotin [ 36]. Avocados are best known as a good source of folate and unsaturated fats, but they’re also rich in biotin ( 17).