B.W. and P.T. discussed the content, researched the data and contributed to writing the article and to reviewing and/or editing of the manuscript before submission. Corresponding author Characteristics of glucose and lipid metabolism and the interaction between gut microbiota and colonic mucosal immunity in pigs during cold exposure Libby, P., Ridker, P. M. & Hansson, G. K. Progress and challenges in translating the biology of atherosclerosis. Nature 473, 317–325 (2011). Dauch, D. et al. A MYC−Aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nat. Med. 22, 744–753 (2016).

Imagine sipping on the zesty and electrifying flavours of Citrus Lemon Lime as you channel the strength of Iron Man, the agility of Spider-Man, or the wisdom of Captain America. Whether you're embarking on an epic adventure or simply need a heroic hydration boost, Arizona x Marvel Super LXR Hero Hydration Citrus Lemon Lime promises a flavourful journey that's as thrilling as a Marvel comic book. So, grab your favourite superhero gear, take a sip, and let the heroic flavours invigorate your spirit, making you feel like you have the strength of Marvel's greatest characters with every refreshing gulp!Zhang, L. et al. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. eLife 6, e28766 (2017). a, Representative western blot analysis of Nrf2, Akt-1 and LXRα in different human HCC cells (cropped blot images, n = 3 independent experiments). β-actin was used as a loading control. b, LXRE reporter assay in different human HCC cells upon lentiviral infection of pL-LXRE-GFP (GFP measurements in individual cells; values represent mean ± SD, n = 5 independent experiments, statistical significance was calculated using two-tailed Student´s t test). c, Weight development of CB17.Cg-Prkdc scidLyst bg/Crl mice upon subcapsular injection of HuH7 cells into the liver and treatment with T0901317/sorafenib or carrier (values represent mean ± SD, n = 6 mice per group statistical significance was calculated using two-tailed Student´s t test). Unprocessed images of the blots and numerical source data are provided as source data files. a, Quantification of lipid peroxidation in Myc OE; Nras G12V; Cdkn2a ARF–/– cells, upon 3 days of treatment with sorafenib, T0901317 or a combination thereof (by analysing the ratio of green and red fluorescence, values represent mean, ± SD, n = 3 cell cultures per condition, statistical significance was calculated using two-tailed Student´s t test, the analysis was repeated twice with similar results). b, Representative western blot analysis of uncleaved or cleaved Atf6, BiP/HSPA5, P-IRE1α (S724) and Xbp-1s in Myc OE; Nras G12V; Cdkn2a ARF–/– cells after 3 days of treatment with T0901317, sorafenib or a combination thereof (cropped blot images, n = 3 independent experiments). α-tubulin was used as a loading control. c, Representative western blot analysis of eIF2α, P-eIF2α (S51), GADD34, BiP/HSPA5 and P-IRE1α (S724) in Myc OE; Nras G12V; Cdkn2a ARF–/– cells after 3 days of treatment with T0901317, BI-882370 or a combination thereof (cropped blot images, n = 3 independent experiments). α-tubulin and Vinculin were used as loading controls. d, Representative western blot analysis of MLKL, P-MLKL (S345), RIPK3, P-RIPK3 (S232) and AIF (nuclear and cytoplasmic fraction) in Myc OE; Nras G12V; Cdkn2a ARF–/– cells after 3 days of treatment with T0901317, sorafenib or a combination thereof (cropped blot images, n = 3 independent experiments). Vinculin and Histone H3 were used as loading controls. e, FACS based analysis of myeloid cells in Myc OE; Nras G12V HCCs upon treatment with T0901317/sorafenib or the corresponding monotherapies (3 d). f-h, Flow cytometry gating strategy. The following populations are identified: immature myeloid cells (iMC: CD11b +,Ly6G +/High,F4/80 −, fraction 1), monocyte-macrophages (Mac-mono: CD11b +,Ly6G +,F4/80 High, fraction 2) and Kupffer cells (Ku: CD11b +,Ly6G +,F4/80 High, fraction 3). Monocyte and macrophages are further distinguished/labeled as Ly6C + (fraction 2a) or Ly6C − (fraction 2b). Samples were gated on viable leukocytes by DAPI exclusion and doublets were excluded using height versus area dot plots. (shown are representative pseudocolor plots, n = 3 mice per group). i,j, Results of FACS analysis in Myc OE; Nras G12V HCCs upon 3 days of treatment with T0901317/sorafenib, T0901317, sorafenib or carrier. Charts show the percentage mean ± SD of monocyte-macrophages (Mac −mono: CD11b +,Ly6G +,F/480 +, i), Kupffer cells (Ku: CD11b +,Ly6G +,F4/80 High, i) and immature myeloid cells (iMC: CD11b +, j) ( n = 3 mice per group, statistical significance was calculated using two-tailed Student´s t test, the experiment was repeated with similar results). k, Treatment of Myc OE; Nras G12V; Cdkn2a ARF–/– cells for 4 days with T0901317 and/or the Bcl-2 inhibitor ABT-199 (quantification of viable cells by crystal violet staining, values represent mean ± SD, n = 3 independent experiments, statistical significance was calculated using two-tailed Student´s t test). Unprocessed images of the blots and numerical source data are provided as source data files. Being a smoker I wanted to improve my lifestyle and started to eat veggies and fruits. Nutrients have dropped in them over decades to level when they simply don't help. Found these high potency vits and you can feel a difference within weeks. Proper!!

Rong, X. et al. ER phospholipid composition modulates lipogenesis during feeding and in obesity. J. Clin. Invest. 127, 3640–3651 (2017). Taking them for a while now and feel better, stronger, more awake, focused and happy with my hair, skin or nails. Highly recommended! Well done LXR 👌🏽 Wolf, M. J. et al. Metabolic activation of intrahepatic CD8 + T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 26, 549–564 (2014).US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00366522 (2009). Horlein, A. J. et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397–404 (1995). Unleash the beast and hydrate your way to ultimate power with Super LXR Hero Hydration: Citrus Lemon Lime flavour! Kennedy, M. A. et al. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab. 1, 121–131 (2005). Yau, T., Chan, P., Epstein, R. & Poon, R. T. Evolution of systemic therapy of advanced hepatocellular carcinoma. World J. Gastroenterol. 14, 6437–6441 (2008).

Griffett, K. et al. The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis. Mol. Metab. 4, 353–357 (2015). Mehlem, A., Hagberg, C. E., Muhl, L., Eriksson, U. & Falkevall, A. Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease. Nat. Protoc. 8, 1149–1154 (2013). Chen, K. F. et al. Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells. J. Pharmacol. Exp. Ther. 337, 155–161 (2011).Faivre, S., Demetri, G., Sargent, W. & Raymond, E. Molecular basis for sunitinib efficacy and future clinical development. Nat. Rev. Drug Discov. 6, 734–745 (2007). US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00836602 (2011). Ito, A. et al. Cholesterol accumulation in CD11c(+) immune cells is a causal and targetable factor in autoimmune disease. Immunity 45, 1311–1326 (2016). Lands, W. E. Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin. J. Biol. Chem. 235, 2233–2237 (1960). Li, Z. et al. Deficiency in lysophosphatidylcholine acyltransferase 3 reduces plasma levels of lipids by reducing lipid absorption in mice. Gastroenterology 149, 1519–1529 (2015).

So, if you're ready to unleash your inner superhero, grab a can of Arizona Marvel Super LXR Hero Hydration Lemon Lime and feel the power coursing through your veins. With every sip, you'll feel like you can take on the world and come out victorious! Zhang, L. et al. The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev. 25, 1262–1274 (2011). Grefhorst, A. & Parks, E. J. Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice. J. Lipid Res. 50, 1374–1383 (2009).Whether you’re heading to the gym, the office, or the classroom, Super LXR™ is for the everyday hero, providing next-level hydration to power your performance.