The lesion stage (precursor lesion, macule, papule, vesicle, ulcer, soft scab, hard scab) was classified by the clinician on each examination day. At the end of the observation period (day 10), the clinician, using the Clinician’s Global Assessment of Therapy (CGAT) evaluated the reaction rate (assessment of the speed of effectiveness of the product) and the reaction quality (assessment of the effectiveness of the product). This assessment was taken over from a clinical trial by Karlsmark et al. 22. Faul, F., Erdfelder, E., Buchner, A. & Lang, A. G. Statistiacal power analysis using G*Power 3.1: Test for correlation and regression analyses. Behav. Res. Methods 41, 1149–1160 (2009). The subjects participating in this study needed to be between 18 and 65 years and were excluded if they showed any painful illnesses of the teeth or gingiva. Most importantly, the outbreak of the HSL could not have occurred more than 24 hours ago. Arduino, P. G. & Porter, S. R. Oral and perioral herpes simplex virus type 1 (HSV-1) infection: review of its management. Oral Dis. 12, 254–270 (2006).

Naposlijetku, cinkov sulfat smanjuje bol i svrbež, te izaziva stezanje, na koji način učvršćuje, zateže i ojačava kožu. Cinkov suflat će stoga pomoći u ubrzavanju zacjeljivanja bolnih površina izazvanih herpesom. To produce significant results, the sample size was estimated with the programme G*Power 3.1.9.2 23. A sample size of 180 patients (60 participants per treatment group) was calculated with a statistical power of 0.8, an alpha error of 0.05, and a 15% drop-out quote with an effect size of 0.5. All data were statistically analysed with the program SPSS 24.0. Petti, S. & Lodi, G. The controversial natural history of oral herpes simplex virus type 1 infection. Oral Dis. 25, 1850–1865 (2019).

Malvy, D. et al. Epidemiology of orofacial herpes simplex virus infections in the general population in France: results of the HERPIMAX study. J. Eur. Acad. Dermatol. 21, 1398–1403 (2007). Zupin, L. et al. Antiviral properties of blue laser in an in vitro model of HSV-1 infection. Microbiol. Immunol. (2018). Active oxygen will accelerate cell renewal, will increase the moisture in the skin and therefore decrease the healing time of cold sore lesions;

The primary endpoint examines the existence of differences between the three products in terms of healing time. The assessments of the reaction rate and the reaction quality by the clinician (CGAT) and by the subject (SGAT) were defined as the secondary endpoints. The analysis of the patient’s questionnaire was determined as the tertiary endpoint. Statistical analysisBetaglukan je ena od sestavin, ki tvorijo oblogo, poleg tega pa še olajša, zaščiti in navlaži kožo, s čimer izboljša zdravljenje rane. The survival curves of the healing time for the primary endpoint were determined using the Kaplan-Meier estimator, and comparisons among the three different treatments were performed by the log-rank test ( p<0.05). All data are fully available without restriction. The survival curves of the healing time for the primary endpoint were determined using the Kaplan-Meier estimator, and comparisons among the three different treatments were performed by the log-rank test ( p< 0.05). All data are fully available without restriction. Van Vloten, W. A., Swart, R. N. & Pot, F. Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections. J. Antimicrob. Chemother. 12, 89–93 (1983). Beta-glukan, osim što oblikuje zaštitni sloj, smiruje, štiti i hidratizira kožu, što pomaže u zacjeljivanju rane;

The course of disease in recurrent HSL generally involves several stages. Within the precursor stage, pain, tingling, or burning sensations in the affected area may occur. This is followed by the appearance of a macule, turning into a papule and leading to the formation of a vesicle. The vesicle bursts, and the formation of a soft scab is initiated. Subsequently, the soft scab is replaced by a hard scab. Over time, the scab falls off, and the lesion is fully healed without scarring 6, 7, 8. While healing, the process is often accompanied by symptoms such as pain, discomfort or reduced self-esteem 6. Complete healing takes seven to ten days 7. Herpes simplex labialis (HSL) is a worldwide infection of the oral and perioral regions caused by an infection with Herpes Simplex Virus type 1 (HSV-1) or, rarely, Herpes Simplex Virus type 2 (HSV-2). Despite the high prevalence of HSL, the disease has not yet been well characterized. The seroprevalence of HSV-1 in Germany was 78.4% from 2008 until 2011 1, 2. While many infections remain subclinical, other patients suffer from painful recurrent infections. U.S. Food and Drug Administration. ZOVIRAX (acyclovir) cream 5% for topical use - Reference ID: 3481551 (2014). Khemis, A. et al. Evaluation of the efficacy and safety of a CS20 (R) protective barrier gel containing OGT compared with topical aciclovir and placebo on functional and objective symptoms of labial herpes recurrences: a randomized clinical trial. J. Eur. Acad. Dermatol. 26, 1240–1246 (2012). Spruance, S. L. et al. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Antimicrob. Agents Chemother. 47, 1072–1080 (2003).Spruance, S. L. et al. Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir. Antimicrob. Agents Chemother. 25, 553–555 (1984).

Fatahzadeh, M. & Schwartz, R. A. Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis, and management. J. Am. Acad. Dermatol. 57, 737–763 (2007). Sulfatni polisaharidi, koji potječu iz crvenih mikroalgi, stvaraju aktivan zaštitni sloj i na taj način pomažu u zaštiti od izlaganja sunčevoj svjetlosti; Korr, G. et al. Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control. BMC Infect. Dis. 17, 471 (2017).

Corporate info

As a sufferer of cold sores all year round this little tube is a life saver. Due to design of the tube (looks like a lip gloss once opened) it can be applied directly to the affected area. I made sure I gave it a good wipe after application though as I wouldn’t want to risk spreading to other areas of my mouth. Dreno, B., Malkin, J. E., Saiag, P. & Batuji-Garin, S. Patient´s profile, burden of disease and quality of life in recurrent herpes labialis: a survey conducted in USA and France. J. Eur. Acad. Dermatol. 26, 1458–1460 (2012). Carson, C. F., Ashton, L., Dry, L., Smith, D. W. & Riley, T. V. Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis. J. Antimicrob. Chemother. 48, 450–451 (2001). Herpatch Herpes Serum možete izravno i jednostavno nanijeti na herpes zahvaljujući aplikatoru u obliku tube. Nakon nekoliko minuta bijela krema stvara zaštitni i prozirni film preko mjehurića od herpesa te pomoću sastojaka pomaže u ubrzavanju procesa zacjeljivanja. Herpatch Herpes Serum djeluje na simptome u svim fazama izbijanja herpesa.