I will often experience bloating, reflux, gas, stomach cramps, and other issues after eating certain foods, but immediately after I started taking these capsules I have experienced no problems at all- even after eating trigger foods. " * Consult your health practitioner before changing your prescribed drug therapy. Where is PepZinGI™ sold? Hewlings, S.J.; Medeiros, D.M. Nutrition: Real People, Real Choices; Pearson Prentice Hall: Upper Saddle River, NJ, USA, 2008. [ Google Scholar] In addition to taking those strides, there are nutrients and botanical ingredients that can also provide support for normal gut permeability, gut health and the gut’s immune function. How Does Gut Reg Support Gut Health And A Healthy Gut Lining? And the thing is, increased intestinal permeability not only gives way to food sensitivities, it can also be exacerbated by them. In other words, it’s a vicious cycle. How Can You Restore Healthy Intestinal Permeability?

Morise, K.; Oka, Y.; Suzuki, T.; Kusuhara, K.; Iwase, H.; Maeda, Y. Clinical effect of Z-103 in the treatment of gastric ulcer. Yakuri Chiryo 1992, 20, 235–244. [ Google Scholar] And while Gut Reg would provide powerful support for a healthy gut lining with PepZin GI® alone, there’s more to the story. Gut Reg also contains L-glutamine, which is the most abundant amino acid in the body and a primary energy source for cells of the immune system that reside in the gut; in fact, glutamine is regarded as “fuel for the immune system.”Along those lines, an adequate supply of glutamine is important for proper immune system functionSakae, K.; Agata, T.; Kamide, R.; Yanagisawa, H. Effects of L-carnosine and its zinc complex (Polaprezinc) on pressure ulcer healing. Nutr. Clin. Pract. 2013, 28, 609–616. [ Google Scholar] [ CrossRef] [ PubMed] Takagi, H.; Nagamine, T.; Abe, T.; Takayama, H.; Sato, K.; Otsuka, T.; Kakizaki, S.; Hashimoto, Y.; Matsumoto, T.; Kojima, A. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J. Viral Hepat. 2001, 8, 367–371. [ Google Scholar] [ CrossRef] Gut Reg is intended for use by healthy adults over 18 years old. Consult your physician before use if you are taking any prescription or over-the-counter medications or being treated for any medical condition. If you experience any adverse reaction to this product, please consult your physician. The stand-alone ingredients in Doctor’s Best PepZin GI have known to be safe in limited amounts of dietary supplementation. Doctor’s Best PepZin GI does not contain any ingredients that have been known to pose any risks for health safety. Foods To Eat with Doctor’s Best PepZin GI?

This special PepZin GI® complex provides greater benefit than either zinc or carnosine used separately. In fact, PepZin GI® is three times more effective than either zinc or carnosine alone. The gastro-supportive benefits of PepZin GI® have been demonstrated in over 20 published studies, which have shown that PepZin GI® provides powerful support for a healthy immune system and gut health by: It has been reported that patients with chronic liver disease show impaired trace element metabolism. Specifically, high levels of iron and copper, and low levels of zinc, selenium, phosphorus, calcium, and magnesium [ 62]. Because of its antioxidant and anti-inflammatory effects, it has been hypothesized that supplemental zinc would be beneficial as an adjunct to treatments for chronic hepatitis C. It has been reported that zinc supplementation enhances the response to interferon therapy in patients with intractable chronic hepatitis C [ 63]. Limit your exposure to environmental toxins and support the body’s natural detoxification pathways with nutrition and supplements. PepZin GI uses a special chelated form of the mineral zinc has a unique ability to exert its effects directly on the cells of the stomach lining. When zinc is complexed to L-Carnosine, it dissociates in the stomach at a slower rate. This prolonged existence allows it to maintain its gastric support effect over a longer period of time. PepZin GI may help maintain the bacterial balance of the stomach and GI tract. Studies suggest that the zinc-L-Carnosine supports the bacterial balance in the stomach as well as help maintain a healthy mucosal lining. Misawa, T.; Chijiiwa, Y.; Nawada, A. Clinical study of Z-103: Clinical effects on gastric ulcer and influence on endocrine dysfunction. Jpn. Pharm. Ther. 1992, 20, 245–254. [ Google Scholar]McGuire, D.; Altomonte, V.; Peterson, D.; Wingard, J.; Jones, R.J.; Grochow, L. Patterns of mucositis and pain in patients receiving preparative chemotherapy and bone marrow transplantation. In Proceedings of the Oncology Nursing Forum, Orlando, FL, USA, 12–15 May 1993; pp. 1493–1502. [ Google Scholar] It’s important to note that when taking any new supplement like Doctor’s Best PepZin GI, that every person will have different results. To achieve the best results with Doctor’s Best PepZin GI it is vital to follow the instructions and be aware that everyone’s body and digestive system is different. With that in mind, the results of taking Doctor’s Best PepZin GI will vary unless you make changes in your diet as well. Then and only then will it be possible to see results and relief from gas, gluten intolerance, IBS, lactose intolerance, bloating, diarrhea and constipation. What ingredients are in Doctor’s Best PepZin GI? When that happens, toxins from the gut (as well as little bits of undigested food) can “leak” into the bloodstream. And this can lead to a long list of problems. Most of which are the result of unwanted inflammation and a dysfunctional immune system. What Causes Leaky Gut? Yanase, K.; Funaguchi, N.; Iihara, H.; Yamada, M.; Kaito, D.; Endo, J.; Ito, F.; Ohno, Y.; Tanaka, H.; Itoh, Y. Prevention of radiation esophagitis by polaprezinc (zinc L-carnosine) in patients with non-small cell lung cancer who received chemoradiotherapy. Int. J. Clin. Exp. Med. 2015, 8, 16215. [ Google Scholar] If you’re overwhelmed by that long list, I get it. I would be too, especially if you’ve been struggling for a while and feel like you’ve “tried everything.”

As a zinc supplement, its use is limited by safety regulations on daily zinc intake, which is about 40 mg per day for most countries. A daily intake of 150 mg PepZinGI™ is equivalent to 34 mg zinc. Xing, L.; Chee, M.E.; Zhang, H.; Zhang, W.; Mine, Y. Carnosine—A natural bioactive dipeptide: Bioaccessibility, bioavailability and health benefits. J. Food Bioact. 2019, 5, 8–17. [ Google Scholar] [ CrossRef][ Green Version]A significant decrease of serum transaminase activities (ALT) was observed in 12 chronic hepatitis C patients who received daily supplementation of 150 mg of ZnC for 48 weeks during combination therapy comprising PEG-IFN-2b plus ribavirin compared to controls ( n = 12). All patients received 300 mg of vitamin E and 600 mg of vitamin C. Supplementation with ZnC decreased plasma thiobarbituric acid reactive substances (TBARS) concentration and prevented the decrease in erythrocyte polyunsaturated fatty acid (PUFA) levels. The authors hypothesized that the ZnC exerted its benefit via its antioxidant properties and that the PUFA levels were evidence of a decrease in lipid peroxidation. They suggested that since zinc is absorbed in the small intestine and transported to the liver via the portal vein, hepatocytes may be exposed to higher levels of zinc than other tissues, especially during supplementation. The authors concluded that ZnC may offer antioxidant protection for chronic hepatitis patients undergoing treatment [ 20]. One of the biggest causes of digestive problems in the western world has all to do with the copious amounts of sugar that’s a part of meals and foods. Sugar is what candida thrives on and the more of it in your system, the more likely that digestive issues occur and Doctor’s Best PepZin GI won’t even help if that continues being the case. Is Doctor’s Best PepZin GI a Scam? Aqil, F.; Munagala, R.; Vadhanam, M.V.; Kausar, H.; Jeyabalan, J.; Schultz, D.J.; Gupta, R.C. Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk. Food Res. Int. 2012, 49, 345–353. [ Google Scholar] [ CrossRef][ Green Version]

What’s more, glutamine supports healthy gut barrier integrity. Everyday physical, mental, emotional and environmental stress increase the body’s utilization of this key gut-nourishing nutrient. A meta-analysis found that glutamine reduced markers of increased intestinal permeability, and a research review presented evidence that glutamine provides support for gut barrier health and function. Tan, B.; Luo, H.Q.; Xu, H.; Lv, N.H.; Shi, R.H.; Luo, H.S.; Li, J.S.; Ren, J.L.; Zou, Y.Y.; Li, Y.Q.; et al. Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial. PLoS ONE 2017, 12, e0175625. [ Google Scholar] [ CrossRef] [ PubMed] Finally, Gut Reg provides Ginger Extract, which has a long, extensive history of use to support digestive health.Ultimamente me dolía mucho la boca del estómago y nada me lo quitaba, hasta que tomé éstas cápsulas, siguiendo los consejos de mi pni. For Americans, the recommended daily intake is 37.5 mg twice daily (75 mg per day). For non-Americans, the recommended daily intake is 75 mg twice daily (150 mg per day). There is no benefit at taking 300 mg per day. Who should take PepZinGI™ under medical supervision? Langer, G.; Fink, A. Nutritional interventions for preventing and treating pressure ulcers. Cochrane Database Syst. Rev. 2014, 12, CD003216. [ Google Scholar] [ CrossRef][ Green Version]