Each and every evening, promptly after the sun disappeared, the stinklers automatically hissed into action, and you could smell the skunk-sulfur vapors. They stunk! If you are a financially-challenged college student, for instance, you may decide to tolerate some light estrogenic exposures. You might go Bronze Level and choose things with the biggest payoffs toward overall health and convenience. I don’t recommend this approach but I empathize and we can still be friends.

Boron: Research strongly supports using boron (at least 3mg but up to 20mg) for numerous health benefits. I especially recommend boron if you have good levels of total testosterone but low levels of free testosterone. Boron helps to free testosterone from SHGB.I use Tri-Boron complex from Swanson, LINKBesides a few of my past college adventures, fish play a central role in this book. They breathe in and soak in estrogenics day and night. We’ll discuss the unfortunate estrogenic burdens within fat, livers, and urine in animals ranging from polar bears to alligators, as well as the resulting health problems from all these exposures, but fish will be featured more consistently and more prominently than the rest. Fish are second only to humans in this book. We can learn a lot from the humble and tasty fish. Recent insights into infertility from artificial estrogens, for example, were first discovered in fish. Oxytocin: I've heard amazing things about this product from a client with the oxytocin receptor genetic issue, OxyLuv, Oxytocin Nasal Spray, LINK. You can also be extra cautious and get a product from a compounding pharmacy (prescription grade). The number one question I continue to get on a daily basis is: "what water filter do you use?" I have 3 recommendations. One is the Purify Guru for your kitchen sink. You'll need an outlet under your sink, btw. If you want to use a different brand, the key principles I follow are (i) avoid plastic, including under-sink storage tanks, in R.O. systems and (ii) look for stainless steel and (iii) filter out the fluoride. I also like the Waterdrop system but have never used it (I've had several Purify Guru units). Alternatives to R.O.? Activated charcoal (sometimes called "carbon") removes estrogenics. It grabs a lot of pharmaceutical drugs, too, but removing estrogenics is key due to inheritable health impacts. Finally, if you want to go with the cheapest possible system that is also good, I recommend the flip-up filter that attaches directly to the faucet such as PUR . You can also travel with these for an Air-BNB and just screw it on/off. In addition, another study’s findings indicate that the timing of when HRT is first administered in relation to when a patient goes through menopause may be important. That 2013 study found that when HRT was started more than 10 years after menopause (or when the patient was 60 or older) there was a reduction in coronary heart disease events and total mortality. WHI Updated Analysis: No Increased Risk of Breast Cancer with Estrogen-Alone. National Institutes of Health. April 11, 2006.

Trimethylglycine "TMG", aka Betaine: Some people experience benefits with acid reflux with TMG-HCl but I find it particularly useful for decreasing homocysteine if you have high levels of homocysteine and the B vitamins just aren't cutting it. Take 2 - 6 pills per day (1 - 3 grams) if you really struggle with homocysteine levels. Jarrow Formulas, TMG, 500 mg, LINK Mono-Species: Life Extension, Bifido Gi Balance [ Bifidobacterium longum is another probiotic to try if you have histamine issues and a high number of food sensitivities ( ref)] LINK Kratom: Please be aware that mitragynine (a major active ingredient of kratom leaves) can inhibit CYP2D6 ( ref). What does this mean? CYP2D6 is a major detox liver enzyme especially involved in breaking down and clearing numerous prescription drugs. In other words, avoid kratom if you're using prescription drugs (or other drugs!) because it may leave those drugs in your body too long. That being said, I've noticed genetic variations in people's responses to kratom but, in case of extreme pain and injury, it's ideal if you can solely utilize kratom over synthetic opioids (e.g. oxycodone/oxycontin, hydrocodone/vicodin, morphine, heroin, fentanyl). At least in animal studies, if is far less addictive than these synthetic opioids ( ref) and therefore a promising candidate for detoxing off addictions to said drugs ( ref). Watch the documentary "Leaf of Faith" for more info. The documentary is produced by my friend, Chris Bell. The "White Vein" leaf is more of a stimulant, LINK, whereas the "Red Vein" variety is known to be more calming with more painkilling properties, LINK Don’t worry, I’ll hold your stuff. You just focus on making friends, my trendy cargo shorts reassured me.Kidney: If you have histamine intolerance issues, try supplementing copper/zinc and grass fed kidney, LINK

Michael Scott: We think a lot alike [Dwight]. Sometimes you will think something and I will say what you’re thinking. Estrogen and estrogenics function within the steroid hormone system. I parallel this steroid hormone system to a radio broadcasting system. And this is where the Brad Paisley radio and receptor analogy falls short. Hormones are not like sound waves or electrical currents. They are physically derived from cholesterol. At least sex hormones are derived from cholesterol. And the sex hormone category includes estrogen and testosterone. There are several adverse effects of estrogen therapy that manifest in different ways depending on the route of administration and whether that route has local or systemic effects. A study exhibiting the adverse outcomes of hormone replacement therapy showed that unopposed estrogen correlates with an increased risk of endometrial and breast cancer. A large prospective study exhibited a positive relationship between estrogen, used in the form of estradiol, and increased breast cancer risk. This study concluded that the relative risk was 1.7 (95 % CI 1.1 to 2.7) for women who used estrogen for more than nine years and 1.8 (95% CI 0.7 to 4.6) for those who used estradiol for more than six years. Another study showed a correlation between estrogen therapy and the risk of stroke, but that has yet to be confirmed. [6]For a fun, real-life example, let’s look at a hormone named leptin. Your body creates and secretes this snazzy hormone every day within your fat cells. Vitamin B3 (Niacin): Life Extension, 800 milligrams, LINK. If you have too much flushing from regular niacin but you still want to lower LPA, use 500 mg of Niacinamide, L INK.

This cookie, set by YouTube, registers a unique ID to store data on what videos from YouTube the user has seen. Calcium D-Glucarate (CGD): CDG assists in liver clearance of estrogenics and with a large number of estrogen-dominance genes, it's worth trying, NOW, 500mg, LINK MTHF (aka B9 aka Methyl Folate) : If all you need is the 5-MTHF, it's far cheaper than a full B-Complex, especially this high quality product from Jarrow, LINK . L-Theanine: A number of people like L-theanine for sleep, taken before bed. Purity is important and that's why Thorne is excellent here, LINK Indole-3-Carinol (i3c): This supplement acts very similar to CGD (lowers estrogenics by increasing liver clearance). However, it requires refridgeration and i3c goes bad within a period of a month or 2. My suggestion is to eat Brassica family plants (fresh live sauerkraut is my favorite) rather than buy i3c.For a second dairy-free option, I also like Natural Force "Organic Bone Broth" protein (especially if you have histamine issues and collagen elevates those issues). I especially like the chocolate flavor, LINK In academia, Dr. Jay earned a Ph.D. in Biochemistry from Boston University School of Medicine and earned a B.A. with a double major in Biology and Theology from Ave Maria University, Florida. His professional scientific work has been published in leading medical and science journals and presented at global venues such as the International Conference on Alzheimer’s Disease (ICAD) in Vienna, Austria, or the Kern Lipid Conference in Vail, Colorado, where Dr. Jay received the “Early Career Investigator Award” in 2014. ANTHONY: Yeah, so there's a list of them that I put together in my book. It's a top 10 list and we’ll certainly go through some of those. It's kind of an extensive list.