Berberine appears to activate AMP-activated protein kinase, which can help regulate how the body uses blood sugar. Researchers believe this activation can help treat diabetes and related health issues, such as obesity and high cholesterol.

Berberine HCL Powder - PureBulk, Inc.

Berberine has an antibacterial action that seems to remove the harmful bacteria in the gut, and thus enhance the growth of healthy bacteria. Taking a supplement capsule (or three) every day isn’t for everyone. For those who dislike swallowing pills or who want to avoid additives, PureBulk offers an additive-free Berberine HCl powder that makes it easy to consume berberine in the way that you prefer. Also, you might know that you love berberine and want to buy it in bulk without paying hand over fist. This is where PureBulk excels: you can buy its Berberine HCl powder (made exclusively from Phellodendron amurense bark) in six different sizes, from 25g all the way up to 1kg. It is not always clear how much of an active ing Liang Y, Xu X, Yin M, et al. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J. 2019;66:51-63. doi:10.1507/endocrj.EJ18-0109

Benefits

Your body doesn’t have enough insulin, a hormone that lowers blood sugar by signaling cells to take glucose from your blood.

Berberine Powder - manufacturer - undersun Berberine Powder - manufacturer - undersun

Chang W, Chen L, Hatch GM. Berberine as a therapy for type 2 diabetes and its complications: from mechanism of action to clinical studies. Biochem Cell Biol. 2015;93:479-86. doi:10.1139/bcb-2014-0107 Zhang J, Li Y, Wu H, et al. Thermally treated berberine-loaded SA/PVA/PEO electrospun microfiber membranes for antibacterial wound dressings. Polymers (Basel). 2022;14:4473. doi:10.3390/polym14214473 Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z, Si S, Pan H, Wang S, Wu J, Wang Y, Li Z, Liu J, Jiang JD Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. (2004-Dec) Berberine is an alkaloid found in the roots, bark, and other structures of many plants, including the Oregon grape ( Mahonia aquifolium), goldenseal ( Hydrastis canadensis), Indian barberry ( Berberis aristata), and European barberry ( Berberis vulgaris). It has a long history of therapeutic uses in Ayurvedic and traditional Chinese medicine and an equally expansive list of potential benefits within the framework of contemporary medicine. Liu H, Tan L, Fu G, Chen L, Tan H. Efficacy of topical intervention for recurrent aphthous stomatitis: A network Meta-analysis. Medicina (Kaunas). 2022;58:771. doi: 10.3390/medicina58060771.

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Karimi, G., Vahabzadeh, M., Lari, P., Rashedinia, M., & Moshiri, M. (2011). “Silymarin”, a Promising Pharmacological Agent for Treatment of Diseases. Iranian Journal of Basic Medical Sciences, 14(4), 308-317. The National Center for Complementary and Integrative Health (NCCIH) notes that if adults take goldenseal, which contains berberine, by mouth it is unlikely to cause severe adverse effects in the short term. However, there is not enough information to show that long-term use is safe. Suadoni MT, Atherton I. Berberine for the treatment of hypertension: a systematic review. Complement Ther Clin Pract. 2021;42:101287. doi:10.1016/j.ctcp.2020.101287

Berberine and Diabetes: Safety, Dosage, and Review - Healthline Berberine and Diabetes: Safety, Dosage, and Review - Healthline

The American Association of Naturopathic Physicians (AANP) notes that berberine supplements are available as supplements or capsules. Lowering cholesterol. Studies have demonstrated that berberine may reduce low-density lipoprotein (LDL, or “bad”) cholesterol, total cholesterol and triglycerides. Berberine activates AMP-activated protein kinase (AMPK), the primary enzyme that monitors and regulates our cellular energy levels. Increasing the amount of AMPK in our bodies gets nutrients where they need to be, effectively controlling our metabolism. This process of AMPK activation is the link to berberine’s benefits for diabetic patients, as well as other conditions like obesity and high cholesterol. AMPK is thought to be a tumor suppressor, too, essentially starving cells while they attempt to form cancerous tumors (though after cancer has developed, AMPK can sometimes promote tumor growth instead). 14 Berberine HCl is an alkaloid found in plants such as Oregon grape, goldenseal, barberry, and golden-thread. People have used it in India and China for hundreds of years. This product is berberine hydrochloride (HCl), and the added hydrochloride is intended to help with digestion.* Berberine can be applied topically to the skin, as well. But berberine improves how cells respond to insulin (insulin sensitivity), promoting better movement of glucose into cells (glucose uptake). It also impacts how glucose gets used. Once your cells have their glucose, you feel less hungry, so you eat less.Xu X, Yi H, Wu J, Kuang T, Zhang J, Li Q, Du H, Xu T, Jiang G, Fan G Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed Pharmacother. (2021-Jan) Wang Y, Yi X, Ghanam K, Zhang S, Zhao T, Zhu X Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism. (2014-Sep) Another study states that berberine helps treat cancer by interfering with its progression and its typical life cycle. It may also play a role in killing cancer cells.