Microorganisms ( Lactobacillus acidophilus CUL60 & CUL21, Lactobacillus gasseri CUL09, Bifidobacterium animalis subsp. lactis CUL34, Bifidobacterium bifidum CUL20), Microcrystalline Cellulose, Vegetarian Capsule Shell (Hydroxypropyl Methylcellulose), Cranberry Extract ( Vaccinium macrocarpon), Anti-caking Agents (Silicon Dioxide, Magnesium Stearate, Tricalcium Phosphate), Corn Maltodextrin, Magnesium Hydroxide, Vitamin B6 (Pyridoxine Hydrochloride). No allergens Kaur L, Gordon M, Baines PA, Iheozor-Ejiofor Z, Sinopoulou V Akobeng AK. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 2020; 3: Cd005573. [ PubMed abstract] However, the authors of a more recent review of the influence of probiotics on blood lipid profiles of healthy adults (in 14 studies with a total of 942 adults treated from 15–150 days) found insufficient evidence to conclude that probiotics improve blood lipid levels [ 56]. Another review found that use of probiotics containing multiple strains produced statistically significant reductions in total and LDL cholesterol levels (by 12.0 and 20.1 mg/dL, respectively), whereas trials that used a single strain did not [ 57].

ProVen Probiotics For Adults – 25 Billion

Numerous probiotic studies have evaluated the effects of various species and strains of bacteria on the prevention of atopic dermatitis, and several meta-analyses have synthesized the findings of these studies. These studies and meta-analyses show that exposure to probiotics during pregnancy and in early infancy might reduce the risk of developing atopic dermatitis in children. For example, a 2018 meta-analysis included 27 randomized controlled trials (RCTs) and one controlled cohort study in a total of 6,907 infants and children exposed to probiotics in utero for 2 weeks to 7 months (via maternal oral supplementation) and/or by oral administration to the infants after birth for 2 to 13 months [ 13]. Between age 6 months and 9 years, probiotic treatment with single strains or mixtures that included Lactobacillus, Bifidobacterium, and Propionibacterium strains significantly reduced the risk of atopic dermatitis from 34.7% in the control group to 28.5% in the probiotic group. A 2017 systematic review of 14 clinical trials, including the two described above, in 1,067 individuals with overweight or obesity showed that probiotics (mostly Lactobacillus administered at various doses for 3 weeks to 6 months) significantly decreased body weight and/or body fat in nine trials, had no effect in three trials, and increased body weight in two trials [ 61]. Another recent systematic review and meta-analysis of 15 RCTs in 957 individuals with overweight or obesity found that supplementation with various doses and strains of probiotics for 3 to 12 weeks resulted in larger reductions in body weight (by 0.6 kg), body mass index (by 0.27 kg/m 2), and fat percentage (by 0.6%) than placebo [ 62]. However, these effects were small and of questionable clinical significance. Not all friendly bacteria are equal. When choosing your friendly bacteria supplement, always look for the following 12 criteria as a start point and then select the best product(s) to suit you and your family. Kumar R, Grover S, Batish VK. Bile salt hydrolase (Bsh) activity screening of lactobacilli: in vitro selection of indigenous Lactobacillus strains with potential bile salt hydrolysing and cholesterol-lowering ability. Probiotics Antimicrob Proteins 2012;4:162-72. [ PubMed abstract]As a food supplement for adults, take one capsule per day with food. Increase to two capsules per day if this is felt necessary. There may be certain times of the month when an increased supplemental dose might be deemed desirable. Directions for use A balanced microbiome helps to support a healthy digestive system, which is central to supporting our health generally. A meta-analysis of 30 RCTs with 1,624 participants (mostly adults age 18 years or older) demonstrated that those treated with probiotics for 3 to 12 weeks had 7.8 mg/dL lower total cholesterol and 7.3 mg/dL lower LDL cholesterol concentrations than those treated with placebo [ 54]. In subgroup analyses, the benefits of probiotics were slightly greater in studies that lasted 8 weeks or longer and in participants who had baseline cholesterol levels higher than 240 mg/dL. Among the strains included in more than three studies, Lactobacillus acidophilus, a mixture of Lactobacillus acidophilus and Bifidobacterium lactis, and Lactobacillus plantarum were associated with significant reductions in total and LDL cholesterol concentrations, but Lactobacillus helveticus and Enterococcus faecium were not. In a smaller meta-analysis of 11 RCTs in 602 adults with normal or high cholesterol levels, those treated with probiotics for 2 to 10 weeks had 6.6 mg/dL lower total cholesterol and 8.5 mg/dL lower LDL cholesterol levels than those treated with placebo, but the probiotic treatment had no significant effects on HDL cholesterol levels [ 55]. The effects were most pronounced with consumption of probiotics for more than 4 weeks by participants with hypercholesterolemia and those age 45 or older. In both meta-analyses, participants included both healthy adults and adults with hypercholesterolemia, CVD, diabetes, or obesity. But there's little evidence to support many health claims made about them. For example, there's no evidence to suggest that probiotics can help treat eczema.

A Healthy Gut for a Healthy Life Concentrated - Probiotics

Staudacher HM, Whelan K. Altered gastrointestinal microbiota in irritable bowel syndrome and its modification by diet: probiotics, prebiotics and the low FODMAP diet. Proc Nutr Soc 2016;75:306-18. [ PubMed abstract]

The most complete combination of friendly bacteria

Bosch M, Fuentes MC, Audivert S, Bonachera MA, Peiro S, Cune J. Lactobacillus plantarum CECT 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels. J Sci Food Agric 2014;94:803-9. [ PubMed abstract] Another meta-analysis included eight randomized clinical trials with a total of 741 participants from birth to 36 months of age who were treated with Lactobacillus or Bifidobacterium for 4 to 24 weeks. The results also suggested that probiotics containing Lactobacillus might reduce atopic dermatitis symptoms in infants and toddlers, but those containing Bifidobacterium did not [ 16]. The treatment significantly improved symptoms in participants with moderate-to-severe forms of the disease but not in those with mild forms. A Cochrane Review of 39 RCTs of single probiotics and probiotic mixtures for the treatment of eczema in 2,599 participants age 1 to 55 years (most were children) found that probiotic treatment might slightly reduce SCORAD scores. However, the researchers concluded that the differences were not clinically significant and that the current evidence does not support the use of probiotics for eczema treatment [ 17]. Wilkins T Sequoia J. Probiotics for gastrointestinal conditions: a summary of the evidence. Am Fam Physician 2017; 96: 170-8. [ PubMed abstract] Cho YA, Kim J. Effect of probiotics on blood lipid concentrations: a meta-analysis of randomized controlled trials. Medicine (Baltimore) 2015;94:e1714. [ PubMed abstract] Bile salt hydrolase activity, which increases the need for new bile acids and thus reduces serum cholesterol levels [ 50-52]