Benacort nasal spray shouldn't be used by certain groups of people unless they have been seen by a doctor first. See your doctor before using Benacort if any of the following apply to you: Available clinical experience shows no indication that budesonide or other glucocorticosteroids induce brain gliomas or primary heptocellular neoplasms in man. Budesonide has been used successfully in the treatment of seasonal allergic rhinitis for several years. Paediatric population: This medicine should not be used in children and adolescents under 18 years of age. Speak with your doctor or pharmacist if you are taking, have taken, or are intending to take any other medicines. Particularly, corticosteroid medicines, which include asthma inhalers, eczema creams, nasal sprays, injections, tablets, and eye/nose drops.

In animal reproduction studies, corticosteroids such as budesonide have been shown to induce malformations (cleft palate, skeletal malformations). However, these animal experimental results do not appear to be relevant in humans at the recommended doses. They have severe or frequent nose bleeds, or have had recent nose ulcers or nose surgery or a nose injury that has not healed. You or the person who's unwell may also have a rash that's swollen, raised, itchy, blistered or peeling. You may not feel the medicine working for the first few days. It takes a few days to feel the full protective effect of this nasal spray, If you are using the spray for hay fever, your doctor may recommend that you start using it 2-3 weeks before the hay fever season starts. This is because it takes a few days of treatment before you feel the full effect, so starting before the pollen count rises will help to prevent symptoms from developing.Follow the instructions that come with your medicine. Do not use more than the maximum number of sprays in 24 hours.

If you're using a new bottle, it will not work the first time you press the spray. Pump the spray a few times until a fine mist comes out. You'll also need to do this if you have not used the bottle for a few days. The metabolism of budesonide is primarily mediated by CYP3A enzymes. Co-treatment with CYP3A inhibitors, e.g. itraconazole, ketoconazole, clarithromycin, HIV protease inhibitors e.g. atazanavir, indinavir, nelfinavir, ritonavir and saquinavir, and cobicistat-containing products, are expected to increase the risk of systemic side effects (see section 4.4). Concomitant use of this product with HIV medicines is contraindicated (see section 4.3). The combination of this medicine with potent CYP3A inhibitors should be avoided unless the benefit outweighs the increased risk of systemic corticosteroid side effects, in which case patients should be monitored for systemic corticosteroid side effects. The interaction is of limited clinical importance for short-term (1-2 weeks) treatment with itraconazole or ketoconazole or other potent CYP3A inhibitors but should be taken into consideration during long-term treatment. If this medicine is co-administered with anti-fungals (such as itraconazole or ketoconazole), the period between treatments should be as long as possible. A reduction of the budesonide dose should be considered Put the tip of the nozzle into 1 nostril, being careful to keep it pointing towards the side of the nostril and not the middle (nasal septum).

The systemic availability of budesonide from this medicine, with reference to the metered dose is 33%. In adults, the maximal plasma concentration after administration of 256 micrograms budesonide from this medicine is 0.64 nM and is reached within 0.7 hours. The AUC after administration of 256 micrograms budesonide from this medicine is 2.7 nmol.h/L in adults. b. Holding the bottle upright, with one finger held on either side of the nozzle, the patient should insert the tip of the nozzle into one nostril. The nozzle should be directed to the side of the nose, and away from the middle of the nose (the nasal septum). The nozzle should be pressed down once or twice depending on the dose required. The spray should then be administered into the other nostril in the same way. Note: it is not necessary to inhale at the same time as spraying. Talk to your doctor or pharmacist if your hay fever hasn't improved after 14 days of using Benacort. Try and stay indoors and avoid grassy areas when the pollen count is high. The pollen count is a measure of how much pollen is in the air and it’s usually highest on hot, sunny days. Patients should commence treatment with two sprays into each nostril each morning. Once symptoms are under control, a maintenance dose of one spray into each nostril each morning may be used. Total daily administration should not exceed four sprays (256 micrograms).

Patients should consult a physician if they develop signs or symptoms of an infection, such as persistent fever, while taking this medicine. Reduced liver function affects the elimination of corticosteroids, causing a lower elimination rate and higher systemic exposure. This may lead to possible systemic side effects.They have severe or frequent nose bleeds, recent nose ulcers or nose surgery or a nose injury that has not healed. The patient should be informed that the full effect of this medicine is not achieved until after a few day's treatment. Do not use the spray more often, or for a longer period of time, than is recommended by your doctor or pharmacist. This could increase the risk of side-effects.

Keep using it regularly every day to keep your hay fever under control. You can use Benacort for up to three months.Follow the instructions provided with the nasal spray. You should shake the bottle gently before use. Be careful not to get the spray in your eyes. Budesonide is metabolized in the liver primarily via oxidative and reductive pathways. Budesonide undergoes an extensive degree (~90%) of biotransformation on first passage by CYP3A4 enzymes to metabolites of low glucocorticosteroid activity. Major metabolites, 6β- hydroxy-budesonide and 16α-hydroxyprednisolone, have similar half-lives but are relatively inactive compared to budesonide having less than 1% of its glucocorticoid and anti-inflammatory activity. you're breathing very fast or struggling to breathe (you may become very wheezy or feel like you're choking or gasping for air) If corticosteroid nasal sprays are used in high doses for long periods of time, they do have the potential to cause side effects similar to those associated with corticosteroids taken by mouth, such as cataracts, raised pressure in the eye or glaucoma, Cushing's syndrome, adrenal suppression and mental health problems. However, these types of side effect are extremely unlikely to occur with this nasal spray, because the amount of budesonide absorbed into the bloodstream from the nose is very low. As a precaution, always use the lowest effective dose needed to control your symptoms, and for the shortest possible time.