For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist. Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Central nervous system features including confusion, disorientation, coma and convulsions are less common in adults than in children. Overdosage with a topical presentation of ibuprofen gel is unlikely; however, it may be encountered following excessive use or accidental ingestion.

Radian B | Muscle Pain Relief Products | Chemist Direct

Patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema, or urticaria) in response to aspirin or other NSAIDs. There is no information available about the safety of this medicine during pregnancy. It is not recommended for use during pregnancy, unless considered essential by your doctor. Seek medical advice from your doctor before using this medicine if you are pregnant. The antipyretic effect is reported to be linked to the effect on the prostanoid synthesis due to the fact that the prostanoids are the main signaling mediator of pyresis in the hypothalamic-preoptic region. Ingestion of the product or excessive use may also lead to camphor poisoning, the symptoms of which include nausea, vomiting, epigastric pain, headache, dizziness, oropharyngeal burning, delirium, muscle twitching, epileptiform convulsions, CNS depression and coma. Breathing is difficult and the breath has a characteristic odour; anuria may occur. Death from respiratory failure or status epilepticus may occur; fatalities in children have been recorded from 1 g. Supportive care, including anticonvulsant therapy, is the mainstay of treatment of camphor intoxication. Gastric lavage may be considered if the patient presents within 1 hour of ingestion; any convulsions must be controlled first. Activated charcoal may be given orally. This cream is unlikely to significantly affect other medicines when applied to unbroken skin. However, the manufacturer recommends that people taking warfarin should get advice from their doctor or pharmacist before using this cream, as if enough salicylate is absorbed through the skin it could potentially enhance the anti-blood-clotting effect of warfarin.Radian B ibuprofen gel is not recommended for children under 14 years of age unless instructed by a doctor. You can use the lotion up to three times a day if needed. Reduce down to morning and evening once your symptoms start to improve. When used on unbroken skin Radian B ibuprofen gel is unlikely to be absorbed in sufficient amounts to affect other medicines that you are taking by mouth. Other medicines containing ibuprofen

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Ibuprofen tablets, capsules, caplets and suspensions are also widely available without brand names, ie as the generic medicine. The exact mechanism of action of ibuprofen is unknown. However, ibuprofen is considered an NSAID and thus it is a non-selective inhibitor of cyclooxygenase, which is an enzyme involved in prostaglandin (mediators of pain and fever) and thromboxane (stimulators of blood clotting) synthesis via the arachidonic acid pathway. Digestive problems such as abdominal pain or indigestion, particularly in people with a history of stomach ulcers.Contraindicated where there is known hypersensitivity to aspirin, other salicylates, or other non-steroidal anti-inflammatory drugs (including when taken by mouth) especially where associated with a history of asthma. Don't cover the treated area of skin immediately after you have applied the lotion; allow it a little time to be absorbed. Don't use Radian B ibuprofen gel for longer than a few weeks unless otherwise advised by your doctor. Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs) Apply to the affected parts and slowly massage well into the skin. For muscular strains and stiffness it is best used after a hot bath.