International Journal of Dental Hygiene : “Efficacy of aloe vera mouthwash versus chlorhexidine on plaque and gingivitis: A systematic review.” For malignant conditions of gastrointestinal tract and accessory digestive organs, emodin (10, 20, 30, 40 μM for 24 and 48 h) decreased cell proliferation and Bcl-2 protein levels and increased caspase-3 protein expression and Bax protein levels in human oral mucosa carcinoma KB cells [ 75]. Moreover, aloe-emodin has been shown to effectively suppress esophageal TE1 cancer cells in a concentration-dependent manner (from 2.5 µM to 20 µM concentrations assayed) through inhibiting AKT and ERK phosphorylation and reducing the number of cells in the S phase [ 76]. Furthermore, Aloe polysaccharide induced autophagy alone and in combination with radiation in pancreatic carcinoma BxPC-3 cells as evidenced in ULK1 mRNA expression upregulation and BECN1 and BCL-2 mRNA expression downregulation [ 77]. Finally, several in vitro and in vivo studies were performed to evaluate the potential anticancer properties of Aloe vera and its isolated compounds in colon cancer (fourth most common cancer and the third leading death cause) [ 78]. Chen et al. [ 79] exhibited cytotoxic properties of aloe-emodin on colon cancer cells at 10, 20, and 40 μM concentrations through activating the apoptotic pathway, increasing ROS production, and cytosolic calcium levels and up-regulating ER stress-related proteins. Moreover, Aloe vera powder and extract 1% and 3% protected C57BL/6J mice from aberrant crypt foci colorectal cancer by increasing hepatic phase II enzyme glutathione S-transferase mRNA levels [ 80]. Furthermore, Aloe vera gel (200 or 400 mg/kg/day orally) reduced inducible NO synthase and COX2 expression, NF-kB activation, and cell cycle progression, inducing cellular factors in BALB/c female mice with induced colitis-associated colon carcinogenesis. Group 2: intralesional injection of hydrocortisone (25 mg/mL) and hyaluronidase (1500 IU) weekly for 6 weeks with antioxidant supplements for 3 months Orally ingested non-decolorized aloe vera leaf extract was listed by the California Office of Environmental Health Hazard Assessment among "chemicals known to the state to cause cancer or reproductive toxicity", [57] possibly resulting from the anthraquinones. [11]

Aloe Vera Oil (Backed by Scientific 11+ Health Benefits of Aloe Vera Oil (Backed by Scientific

Aloe vera extract (50%) increased cell viability of dental pulp stem cells being useful for avulsed broken teeth [ 4]. This effect is attributed to polysaccharides, mainly acemannan, by inducing osteogenic-specific gene expressions, DNA synthesis, growth factor, and JAK-STAT pathway [ 5, 6]. Moreover, Aloe vera (225 mg/kg) exerted a radioprotective effect against salivary gland dysfunction in a rat model as evidenced in an increase of salivary flow rate [ 7]. In another study, Thunyakitpisal et al. [ 62] demonstrated that acemannan increased IL-6 and IL-8 expression and NF-κB/DNA binding in human gingival fibroblast via a toll-like receptor signaling pathway. Since there is a relation between high IL-1β levels and periodontal diseases, Na et al. [ 63] investigated the anti-inflammatory properties of aloin in human oral KB epithelial cells stimulated with saliva from healthy volunteers. This study revealed that those saliva samples with high content in IL-1β stimulated IL-8 production in KB cells, and pretreatments with aloin inhibited IL-8 production by decreasing p38 and extracellular signal-regulated kinases pathway. Chemicals Listed Effective December 4, 2015, as Known to the State of California to Cause Cancer: Aloe Vera, Non-Decolorized Whole Leaf Extract, and Goldenseal Root Powder". California Office of Environmental Health Hazard Assessment. 4 December 2015 . Retrieved 21 February 2020. Periodontitis is a serious and common dental affliction in which gums are infected and become inflamed, causing tissue and bone destruction. Gingivitis is the initial phase of periodontitis and is caused by dental plaque. Significant clinical evidence has demonstrated that Aloe vera mouthwash and gel are effective in the prevention and treatment of gingivitis and periodontitis by reducing gingival index, plaque index, and probing depth and by increasing bone fill and regeneration [ 8, 9, 10, 11, 12, 13, 14]. Aloe vera has proven to be as effective as other usual treatments such as chlorhexidine, alendronate, and chlorine dioxide [ 8, 10, 11, 13]. This condition, which causes stinging pain and itchiness of the skin, can be remedied and prevented with aloe vera.

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Gastritis is an inflammation of mucous membrane layer of the stomach. Aloe vera gel protected in a Balb/c mouse model of alcohol-induced acute gastritis by increasing matrix metalloproteinase-9 inhibitory activity [ 24]. Al-Ali says: 'The antioxidants and vitamins have also been shown to neutralise the effects of ultraviolet (UV) radiation, repairing your skin from existing UV damage and helping prevent fine lines.' Guo X, Mei N. Aloe vera: a review of toxicity and adverse clinical effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2016;34(2):77-96. doi:10.1080/10590501.2016.1166826 Relieves heartburn. Heartburn is a painful condition that involves acid leaving the stomach and traveling up the esophagus. A recent study has shown that aloe vera juice can reduce the symptoms of heartburn without any uncomfortable side effects.

Aloe Vera Oil – Essential Oils Aloe Vera Oil – Essential Oils

A. Yes, you can use aloe vera oil for hair daily, as it is safe. Q. Can I leave aloe vera oil in my hair overnight? The dose of 10 mg/kg of Aloe vera aqueous extract (3 times daily for a week) resulted to be the most effective in morphine withdrawal syndrome in morphine-dependent female rats as shown in agitation, disparity, and floppy eyelids reduction [ 129]. Using aloe can help prevent fungal infections. It reduces the growth offungus on the scalp, which leads to infections. Using aloe vera oil for hair growth, dandruff, and skin for skin At the blood level, the oral administration of Aloe vera gel prevented and restored lymphopenia and erythropenia as well as IgA secretion on cyclophosphamide-induced genetically modified mice [ 125]. Moreover, Aloe vera ethanol extract (200 mg/kg, 400 mg/kg, and 600 mg/kg) normalized levels of white blood cells, red blood cells, and platelet count through antioxidant mechanisms [ 126].It could also be used to treat internal diseases such as stomach ulcers and genital herpes, among others. There are plenty of people claiming that Aloe vera oil can help hair to grow faster however, more clinical evidence is needed to prove this claim. Strengthen hair strands Dat A, Poon F, Pham K, et al. Aloe vera for treating acute and chronic wounds. Cochrane Database Syst Rev. 2012;(2):CD008762. doi:10.1002/14651858.CD008762.pub2. Lombardi N, Crescioli G, Maggini V, et al. Anthraquinone laxatives use and colorectal cancer: a systematic review and meta-analysis of observational studies. Phytother Res. 2022;36(3):1093-1102. doi:10.1002/ptr.7373

Aloe Vera on Face Benefits and Side Effects of Applying Aloe Vera on Face

There is large-scale agricultural production of Aloe vera in Australia, [46] Cuba, the Dominican Republic, China, Mexico, [47] India, [48] Jamaica, [49] Kenya, Tanzania, South Africa, [50] Spain, [51] and the United States, [52] with much of the output going toward the cosmetics industry. [4] Uses [ edit ] Korea interested in Dominican 'aloe vera' ". DominicanToday.com—The Dominican Republic News Source in English. 7 July 2006. Archived from the original on 6 December 2008. Apply the oil to the skin to hydrate and moisturize it, or add a few drops to your daily moisturizer. Aloe vera gel is used commercially as an ingredient in yogurts, beverages, and some desserts, [54] but at high or prolonged doses, ingesting aloe latex or whole leaf extract can be toxic. [5] [9] [11] [15] Use of topical aloe vera in small amounts is likely to be safe. [9] [39] Topical medication and potential side effects [ edit ] a b c d e f g h i Guo, Xiaoqing; Mei, Nan (2 April 2016). "Aloe vera: A review of toxicity and adverse clinical effects". J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 34 (2): 77–96. doi: 10.1080/10590501.2016.1166826. PMC 6349368. PMID 26986231.There are hundreds of aloe plants, but aloe vera is unique in its ability to help you inside and out. Aloe vera is the only edible form of aloe. The aloe vera plant is native to the Arabian peninsula, but it grows throughout the world. This shrubby, pointy plant has been cultivated for its soothing gel for thousands of years.