Klyachko, V. A., and Stevens, C. F. (2003). Connectivity optimization and the positioning of cortical areas. Proc. Natl. Acad. Sci. U.S.A. 100, 7937–7941. doi: 10.1073/pnas.0932745100 English–Arabic English–Bengali English–Catalan English–Czech English–Danish English–Hindi English–Korean English–Malay English–Marathi English–Russian English–Tamil English–Telugu English–Thai English–Turkish English–Ukrainian English–Vietnamese

The bigger the better – Expressions, Idioms, and Slang

The similarity in brain design among primates, including humans, indicates that brain systems among related species are internally constrained and that the primate brain could only evolve within the context of a limited number of potential forms. It means that internal factors of brain design may be the primary determinants constraining the evolution of the brain and that geometric similarity among species in the functional organization of the brain may be derived from a common ancestor rather than being immediately evolved in response to specific environmental conditions. Conflict of Interest Statement Macphail, E. M., and Bolhuis, J. J. (2001). The evolution of intelligence: adaptive specializations versus general process. Biol. Rev. 76, 341–364. doi: 10.1017/S146479310100570X Therefore the most obvious problem imposed by large brains is increasing distances among the neuronal somata of functionally related regions and the inevitable lengthening of their essential communication lines, the axons. Importantly, the axonal length and volume increase much more rapidly than the number of neurons. Furthermore, a proportional increase of neurons and connections would inevitably lead to a rapid increase of synaptic path length, defined as the average number of monosynaptic connections in the shortest path between two neurons ( Watts and Strogatz, 1998; Buzsáki and Draguhn, 2004; Sporns et al., 2004). So that the path length can be maintained, short cut connections can be inserted, resulting in small-world- and scale-free-type networks ( Sporns et al., 2007; Bullmore and Sporns, 2012). The findings showed that women preferred taller men with broader shoulders and narrow hips (V-shaped, instead of pear-shaped), which supports earlier research.Kaas, J. H. (2008). The evolution of the complex sensory and motor systems of the human brain. Brain Res. Bull. 75, 384–390. doi: 10.1016/j.brainresbull.2007.10.009 Van Essen, D. C. (1997). A tension-based theory of morphogenesis and compact wiring in the central nervous system. Nature 385, 313–318. doi: 10.1038/385313a0 Sporns, O., Honey, C. J., and Kötter, R. (2007). Identification and classification of hubs in brain networks. PLoS ONE 2:e1049. doi: 10.1371/journal.pone.0001049 She finally caught her breath enough to speak and managed to giggle at her predicament. Her huge tits were hanging down, pushed up by her colossal stomach. She looked up at her lovers and smiled broadly.

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Hofman, M. A. (1985b). Neuronal correlates of corticalization in mammals: a theory. J. Theor. Biol. 112, 77–95. doi: 10.1016/S0022-5193(85)80117-X

Innocenti, G. M., Vercelli, A., and Caminiti, R. (2013). The diameter of cortical axons depends both on the area of origin and target. Cereb. Cortex. doi: 10.1093/cercor/bht070. [Epub ahead of print].

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Too much girth can cause tearing if you’re not careful, especially during anal sex. Then there’s the whole choking and gag reflex to contend with during oral.In the neocortex, billions of neurons are interconnected via a massive yet highly organized network of axonal and dendritic wiring. This wiring enables both near and distant neurons to coordinate their responses to external stimulation. Specific patterns of cortical activity generated within this network have been found to correlate with cognitive and perceptual functions ( Wang, 2010). Understanding the organizing principles of cortical wiring, therefore, represents a central goal toward explaining human cognition and perception in health and disease. Despite more than a century of endeavor, however, the organizing principles and function of cortical connectivity are not well understood (see e.g., Douglas and Martin, 2004; Bohland et al., 2009; Budd and Kisvárday, 2013) Budd, J. M. L., and Kisvárday, Z. F. (2012). Communication and wiring in the cortical connectome. Front. Neuroanat. 6:42. doi: 10.3389/fnana.2012.00042 Wen, Q., and Chklovskii, D. B. (2005). Segregation of the brain into gray and white matter: a design minimizing conduction delays. PLoS Comp. Biol. 1:e78. doi: 10.1371/journal.pcbi.0010078

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I’m sorry to hear what you’ve been through. I’m glad you are still able to have an enjoyable sex life and I agree with you that smaller can be better.” Although, it’s not the pounding that matters… Zatu has an excellent range of games and for most of them the best prices too. Delivery is always fast and I have never received a game in bad condition. 10/10 would recommend. Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands As long as your partner’s up for it, mix things up with sex in different places or consider exploring your kinky side. It is evident that the potential for brain evolution results not from the unorganized aggregation of neurons but from cooperative association by the self-similar compartmentalization and hierarchical organization of neural circuits and the invention of cortical folding, which reduces the interconnective axonal distances. The competing requirements for high connectivity and short conduction delay may lead naturally to the observed architecture of the primate neocortex. Obviously, the brain functionally benefits from high synaptic connectivity and short conduction delays. The design of the primate brain is such that it may perform a great number of complex functions with a minimum expenditure of energy and material both in the performance of the functions and in the construction of the system. In general there will be a number of adequate designs for an object, which, for practical purposes, will all be equivalent.

Ringo, J. L., Doty, R. W., Demeter, S., and Simard, P. Y. (1994). Time is of the essence: a conjecture that hemispheric specialization arises from interhemispheric conduction delay. Cereb. Cortex 4, 331–343. doi: 10.1093/cercor/4.4.331