IPR-MUS LD 50 85 mg/kg,IVN-GPG LD 50 120 mg/kg, IVN-MUS LD 50 239 mg/kg, IVN-RAT LD 50 500 mg/kg, IVN-RBT LD 50 410 mg/kg

Arthralgia (12%), Dizziness (12%), Headache (12%), Nasopharyngitis (12%), Anaphylaxis, Angioedema, Congestive heart failure, Peripheral vascular disease,Pulmonary edema, Diarrhea, Dyspepsia, Polycythemia vera, Sore throat, Nervousness, Rhinitis, Glossitis, Hypoesthesia Vitamins are organic compounds important for health. Minerals are inorganic compounds that are also needed for normal functioning of the body 3.For intravenous injection, dilution into a large volume parenteral such as Normal Saline, Water for Injection, or Glucose is recommended to minimize the adverse reactions associated with intravenous injection. Intensive treatment of B12-deficient megaloblastic anemia may cause hypokalemia and sudden death. Use with caution in patients with Leber optic nerve atrophy. Thrombocytosis may occur with treatment of severe vitamin B12 megaloblastic anemia Symptoms of calcitriol toxicity mirrors the early and late signs and symptoms of vitamin D intoxication associated with hypercalcemia . Early signs include weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain and metallic taste. Late signs are characterized by polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated SGOT and SGPT, ectopic calcification, hypertension, cardiac arrhythmias and, rarely, overt psychosis . Calcium is used to prevent or treat negative calcium balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofoactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways.

Branded multivitamin products offer varied nutritional provisions based on various parameters such as gender and age. Seven Seas Perfect 7 range is an example of this. Perfect 7 Man contains Vitamin D for the maintenance of muscle and bones, while Perfect 7 Woman contains zinc, which contributes towards healthy hair, skin and nails. In normal subjects, approximately 27% and 7% of the radioactivity appeared in the feces and urine, respectively, within 24 hours . Calcitriol undergoes enterohepatic recycling and biliary excretion. The metabolites of calcitriol are excreted primarily in feces. Cumulative excretion of radioactivity on the sixth day following intravenous administration of radiolabeled calcitriol averaged 16% in urine and 49% in feces . Folic acid is essential for the production of certain coenzymes in many metabolic systems such as purine and pyrimidine synthesis. It is also essential in the synthesis and maintenance of nucleoprotein in erythropoesis. It also promotes WBC and platelet production in folate-deficiency anaemia. Do discuss this with your doctor before taking Multibionta as it can also disturb your stomach if you take it on an empty stomach. Calcitriol is used for the correction of the abnormalities of Calcium and Phosphate metabolism in patients with renal osteodystrophy.Hereditary sideroblastic anemia: 250 mg of vitamin B6 daily, reduced to 250 mg of vitamin B6 weekly once adequate response is achieved. Prophylaxis of megaloblastic anaemia in pregnancy, Supplement for women of child-bearing potential,Folate-deficient megaloblastic anaemia,Prophylaxis of neural tube defect in pregnancy

Calcitriol is one of the most important active metabolites of vitamin D3. It is normally formed in the kidney from its precursor, 25-hydroxycolecalciferol (25-HCC). Physiological daily production is normally 0.5-1.0 mcg and is somewhat higher during periods of increased bone synthesis (e.g. growth or pregnancy). Calcitriol promotes intestinal absorption of Calcium and regulates bone mineralization. Stopping the use of the Multibionta capsule too early can impact its effectiveness on the body overall. That is why it is important to discuss the dosage and intake of the medicine with your doctor. What are Multibionts Capsule Uses? The drug is safe in normal doses in pregnant women, but a daily intake of 5 gm or more is reported to have caused abortion. The drug may be taken safely during lactation. Immobilised patients, e.g. those who have undergone surgery, are particularly exposed to the risk of hypercalcaemia. Patients with normal renal function who are taking Calcitriol should avoid dehydration. Adequate fluid intake should be maintained.Multibionta can interact with other medicines and increase the risk of side effects. The medicines that are more likely to interact with Multibionta include: We all strive to eat well and many of us do, but we are not always able to eat a varied diet or reach the recommended daily amounts of nutrients for various reasons. A recent study by Imperial College London found that eating ten portions of fruit and veg a day may have benefits 1. So, why not give it a try? Altering your habits, traits and behaviours can improve our nutrient intake.