If berberine can help treat cancer, inflammation, diabetes, and other conditions, it may be because of a beneficial effect on gut microbiota, according to some research published in 2020. Scientists have found links between the gut microbiome — colonies of bacteria in the gut — and these conditions. Also, results of a study of rats indicate that berberine could delay the onset of high blood pressure and, when it does develop, help reduce its severity. Obesity High levels of low-density lipoprotein (LDL) cholesterol and triglycerides may increase the risk of heart disease and stroke.

Preparation and Evaluation of Antidiabetic Agents of

Berberine treatment has also been shown to increase the abundance of Akkermansia in the intestine and alleviate atherosclerosis in Apoe (-/-) mice fed a high-fat diet ( Zhu etal., 2018). Collectively, these data indicate that berberine may play different regulatory roles in different disease models and that berberine acts via many different systems on a range of targets in the treatment of disease. ConclusionsAlso, a double-blind study found that individuals with metabolic syndrome who took 200 mg of barberry three times a day experienced decreases in their body mass index readings. However, it may be a good choice for people who don’t want to take three split-up doses throughout the day, as this supplement recommends only taking one serving per day. Another study found that berberine has the ability to damage the DNA and protein of certain bacteria. Inflammation

Berberine for Weight Loss and Insulin Resistance – Cleveland Berberine for Weight Loss and Insulin Resistance – Cleveland

The global obesity epidemic is prompting significant efforts to identify host and environmental factors that affect energy balance in the human body. For example, Turnbaugh etal. reported that host obesity is related to an increase in the intestinal F:B ratio ( Turnbaugh etal., 2006). Berberine has been shown to revert the structural changes in the GM induced by a high-fat diet and regulate diversity in the GM. Berberine has also been shown to change 134 operational taxonomic units (OTUs) that were identified by nearest shrunken centroids analysis in obese rats induced by a high-fat diet, and was also associated with changes in obesity phenotypes. Sixty of the 134 OTUs were significantly increased with berberine treatment, particularly those belonging to putative SCFA-producing bacteria, including Allobaculum, Bacteroides, Blautia, Butyricicoccus, and Phascolarctobacterium. The modulation of berberine-induced GM plays a significant role inthe development of IBD and atherosclerosis ( Cui etal., 2018). IBD is caused by dysregulation of the immune responses in the intestinal mucosal in hosts that are genetically susceptible ( Strober etal., 2007). Berberine has also been shown to inhibit the production of pro-inflammatory cytokines in colonic macrophages and epithelial cells, and promote apoptosis in the colon macrophages of mice(C57BL/6) treated with DSS. Berberine was also shown to reduce the activation of the signaling pathways that produce proinflammatory cytokines (including mitogen-activated protein kinase and NF-κB) in colonic macrophages and epithelial cells in DSS-treated mice ( Yan etal., 2012). In the intestinal mucositis induced by 5-fluorouracil (5-Fu) using rat model, berberine significantly increased the levels of butyrate and glutamine in feces from 5-Fu treated rats. In terms of gut microbiota, berberine enriched the relative abundance of Firmicutes and decreased Proteobacteria at the phylum level. Meanwhile, berberine increased the proportion of unclassified_f_ Porphyromonadaceae, unclassified_f_ Lachnospiraceae, Lactobacillus, unclassified_o_Clostridiales, Ruminococcus, Prevotella, Clostridium IV, and decreased Escherichia/Shigella at the genera level ( Chen etal., 2020).Although it’s normal for your blood sugar levels to fluctuate throughout the day, prolonged high blood sugar levels can cause various health problems, including organ damage ( 5). Lichao Zhang 1,2,3† Xiaoying Wu 1,2,4† Ruibing Yang 5 Fang Chen 6 Yao Liao 1,2,3 Zifeng Zhu 1,2,3 Zhongdao Wu 1,2,3 Xi Sun 1,2,3* Lifu Wang 1,2,3* A. muciniphila is a gram-negative anaerobic bacterium that is selectively reduced in the fecal microbiota of patients with colitis or colitis-associated cancer (CAC). amuc_1100 is a special protein that can be isolated from the outer membrane of A. muciniphila. Once isolated, amuc_1100 still exerts biological activity and plays a beneficial role at the temperature used for pasteurization. A. muciniphila or amuc_1100 has been shown to alleviate colitis and CAC, reduce CD8 + cytotoxic T lymphocytes (cTls), and the infiltration of macrophages in the colon, and may therefore represent a promising therapeutic target for the treatment of colitis and CRC ( Wang etal., 2020). However, research has shown that the population of Akkermansia was significantly increased in a mouse model (BALB/c) of CAC fed a high-fat diet ( Wu etal., 2016). The Apc min/+ mouse model (C57BL/6J) has a tumorigenic phenotype and can develop intestinal tumors; research has shown that high-fat diet could accelerate the process of carcinogenesis. Berberine has been shown to significantly reduce intestinal-tumor development and cause changes in the structure of the GM in Apc min/+ mice (C57BL/6J) fed on a high-fat diet ( Wang etal., 2018). Berberine can clearly inhibit the increased abundance of Verrucomicrobia at the phylum level. At the genus level, berberine can suppress Akkermansia and increase the abundance of some SCFA-producing bacteria ( Wang etal., 2018). Some research suggests that berberine works similarly to the drug metformin, which doctors often prescribe to treat type 2 diabetes. In fact, berberine may have the ability to change the bacteria in the gut, which could help treat both obesity and diabetes. Polycystic ovary syndrome

Berberine: A Review - PMC The Anti-Cancer Mechanisms of Berberine: A Review - PMC

It may help reduce LDL, or “bad” cholesterol, and increase high-density lipoprotein, or “good” cholesterol.Asbaghi, O., et al. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials [Abstract]. This well-tolerated extract works at the cellular level to support healthy blood sugar levels already in the normal range, even after eating a meal or sugary treat. Habtemariam, S. (2020). Berberine pharmacology and the gut microbiota: A hidden therapeutic link [Abstract]. Concurrently, we should strengthen the mechanism of berberine in the treatment of vascular diseases. Novel technologies that could be employed to explore the mechanism of action of berberine in the treatment of vascular diseases include CRISPR–CAS-9 gene editing, metabolomics, proteomics, and genomics. Most importantly, recently published investigations of the pharmacological mechanisms of berberine may provide new insights into the treatment of vascular diseases by berberine. For example, Zhao and others demonstrated that 560mg/kg berberine administered orally in Coptis chinensis can significantly increase insulin secretion via the potassium voltage-gated channel subfamily H member 6 (KCNH-6) potassium channel in mice with HFD-induced hyperglycemia ( Zhao et al., 2021a). Overall, this study comprehensively reviewed and summarized the pharmacokinetics properties and therapeutic potentials of berberine in diverse vascular diseases, thus providing experimental evidence for future research to discover novel drugs from Chinese medicine monomers. Author Contributions