Endurance training modulates intramyocellular lipid compartmentalization and morphology in skeletal muscle of lean and obese women. J Clin Endocrinol Metab. (2013) 98:4852–62. 10.1210/jc.2013-2044 The specific carbohydrate diet breaks the cycle by depriving the microbial world in the intestine of the food that it needs to overpopulate the gut. In the above instance, due to her distorted reasoning, all the other components got distorted as well. And at last, when her behavior matches with her initial thoughts, it will only reinforce her thoughts of not being good enough or others judging her. Thus the cycle will repeat itself. Picard M, McEwen B, Epel E, Sandi C. An energetic view of stress: focus on mitochondria. Front Neuroendocrinol. (2018) 49:72–85. 10.1016/j.yfrne.2018.01.001 Pressman S, Cohen S, Miller G, Barkin A, Rabin B, Treanor J. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol. (2005) 24:297–306. 10.1037/0278-6133.24.3.297

Breaking the Vicious Cycle: 5 Family Therapy Interventions Breaking the Vicious Cycle: 5 Family Therapy Interventions

Have you heard my dad laugh? He has a burst of hearty laughter, full of life and hope. Never afraid to speak his mind, he talks with passion, and when he is having an experience, he lives in that moment.Studies of loneliness and chronic social isolation in humans and animal models have consistently found an overactivation of the HPA axis, supported by findings of higher cortisol awakening responses (CAR), greater total GC output (area under the curve; AUC), and flattened diurnal cortisol rhythms in lonely individuals ( 33– 39). Persistently high cortisol levels are associated with far-reaching physiological consequences, including hyperglycemia, increased vascular resistance, redistribution of body fat to the viscera, and accelerated biological aging ( 40). These changes can directly lead to insulin resistance and hypertension and thus represent a mechanism by which loneliness may drive the development of metabolic syndrome. Neuroprotective effect of oxytocin on cognitive dysfunction, DNA damage, and intracellular chloride disturbance in young mice after cranial irradiation. Biochem Biophys Res Commun. (2022) 612:1–7. 10.1016/j.bbrc.2022.04.099

Breaking the Vicious Cycle : Intestinal Health Through Diet

The response to the stress arising from social disconnection, whether adaptive or maladaptive, is ultimately instantiated by the mitochondria. Mitochondrial dynamics involved in the stress response are energy-demanding, particularly when stress-buffering strategies at the psychosocial level are insufficient to prevent the progression from an adaptive response to stress arising from social disconnection to the chronic stress response tied to loneliness. Thus, interventions that build metabolic fitness, or mitochondrial bioenergetic capacity, will build stress resilience. Given their central role in cellular metabolism, the implication of mitochondrial dysfunction in the etiology of metabolic diseases is unsurprising but notable, with persistent hyperglycemia serving as an illustrative example. Chronic states of elevated blood glucose–whether caused by chronic stress, inflammation, or overnutrition–are associated with the accumulation of mtDNA damage and fragmented mitochondria ( 66, 67). Correspondingly, mtDNA mutational burden is associated with age-related chronic disease; mtDNA mutations typically increase with age, especially in patients with diabetes ( 68). Mitochondrial dysfunction, such as impaired energy production and altered dynamics, has been extensively described in diabetic cardiomyopathies ( 69), one of the main causes of death for patients with MetS. Similar associations between mtDNA damage and other conditions of MetS have been described extensively elsewhere ( 70– 72). As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, When you find something that you are passionate about, the only way you go is up. You have the greatest motivation of all, your progress. Through my father, I have learned the importance of finding what I am truly passionate about and pursue that. It is the key to live a fulfilled life. Breaking the cycleWhen starting out, when symptoms such as diarrhea and cramping are severe, the following basic diet should be followed for up to five days. In other cases, one or two days on this basic diet is sufficient. The amounts of the specified foods to be eaten depend on the appetite of the individual; there is no restriction as to quantities eaten. The Specific Carbohydrate Diet Association (SCDA) invites you to join us in this noble mission of healing and empowerment. Whether you are a follower, caregiver, healthcare professional, researcher, or company, your involvement strengthens the SCD Community and advances the global impact of the Specific Carbohydrate Diet™.