Benfotiamine is an S-acyl derivative of thiamine known for its ability to improve blood sugar management and support peripheral nerve function. TTFD was shown to influence heavy metal retention and excretion. This does not mean it that it is anywhere near as effective as DMSA, DMPS or EDTA. It also doesn’t mean that one should use TTFD solely for its effect on heavy metals, since there are more efficient ways of dealing with heavy metal toxicity. cases of cervical spondylotic radiculopathy treated with control of TTFD and naproxen – 75% effective (2009) cases of sudden-onset deafness was treated with 150mg TTFD orally, with most therapeutic effect seen after 2-3 months of treatment

cases of delayed peripheral neuropathy due to organophosphate poisoning treated with acupuncture and TTFD injection (2001) TTFD used to treat edema and weight gain and marginal thiamine deficiency – authors recommend TTFD instead of thiamine HCL (2021) I’ve been feeling below par with chronic health issues for years, explored many allopathic and alternative approaches and even trained to a high level in bio-psycho-social wellbeing myself as a result of my debilitating symptoms. Tears of joy fell when I discovered Elliot’s protocols. Consequently, I’m both hopeful and optimistic about the future. I have Hashimoto’s and have not felt well under all the differ The lactate metabolites were assessed for the four groups allocated as vehicle, TTFD-1X, TTFD-2X, and TTFD-5X at three repeated time points within group. Lactate production rate was calculated as, after exercise divided by before exercise (B/A) and the lactate difference between after exercise and after rest divided by after rest was defined as the clearance rate. Values in the same row with different superscript letters (a, b) differ significantly, P< 0.05, by one-way ANOVA.Pyridoxine hydrochloride, the synthetic form of what most supplement makers (putatively) call “vitamin B6,” would be an exception, wouldn’t it? I was diagnosed with Parkinsonism when I went to the ER due to Vertigo (I was rolling my fingers and it was very uncomfortable for me to stop it). I have not notice doing this since starting TTDF. Yesterday, I notice while wearing a fairly new pair of shoes a little vertigo (they are now in the trash). So my question is, does this sound like thiamine deficiency that started a long time ago to you? What would be your recommendations in this case in terms of taking the Alithiamine. Should I increase dose? Should I try to lower the dose? Should I be able to reach a point of not having to rely on the supplement in the future? Processed food are fortified with B1 (thiamine HCL is the most common which doesn’t cross the BBB). With the rise of neurological diseases they should fortify with TTFD.

As a kid I was very active, tanned easily, had a lot of energy and pretty normal as far as kids go. In my country, prescribing antibiotics is normal enough for general problems (even when it has no effect), not sure it’s related but I thought worth mentioning as it’d have been prescribed to me a few times when growing up. Around the age of 12, I started to have issues with my gut. I would get intense abdominal pain and stopped going to school as a result. Shortly after this, I became very pale and very weak physically, I was far weaker than anyone else in the school by a significant margin and so pale that it everyone noticed and used to insult me over it. The changes were clearly very extreme and abnormal. Over the years after this, I gained weight and continued to be relatively physically weak and very pale (unable to tan). It stayed like this relatively unchanged until I hit my 20s. Worth noting, my diet as a kid was quite bad, it consisted of a lot of junk food and soda, as I was very fussy with food. It was difficult to get me to eat meat/vegetables and I never consumed fruit. This was less a case during my teenage years and not at all into my 20s. Also worth noting, once the stomach issues began, I became heavily constipated and had consistent issues with digestion ever since, particularly it seems with stuff that are very “doughy”, like pizza would have a high chance of triggering abdominal pain. At some point in this timeline, I was also prescribed PPIs which I used for over a month for acid reflux issues (PPIs are horrendous of course, I know that now).My doctors all think I’m fine because my whole blood thiamine is actually on the higher end of normal and pretty much every other blood test is normal. children with Down’s Syndrome, 12 of which were administered TTFD for 12 months and 12 of which were administered TTFD for 6 months. No serious adverse events noted. You previously advised to raise the dose “gradually” until symptoms yield. Do you ahve a general schedule to increase? For example, I waited at 150mg for a week, then I raised to 200mg. Dr. Lonsdale & Dr. Marrs, I was diagnosed with Parkinson’s last year, Symptoms began in 2018. I and 3 of my 4 siblings plus my mother are hypothyroid. I have been taking levothyroxine for over 10 years. I began taking thiamine HCL following Dr. Constantini’s protocol at the end of July 2021 hoping to improve my PD.

I knew enough about the water soluble vitamins to know I needed them. I knew I urinated more than normal and so on. So I was taking vitamins and minerals but I was not entirely consistent in use. Diabetic lactic acidosis – 100mg/day IV for 7 days resolution in symptoms, followed by 75mg indefinitely (2008) For women experiencing symptoms of premenstrual syndrome (PMS), 100 mg is probably the best dose to take to minimize these symptoms.Biotin-responsive holocarboxylase synthetase deficiency: Genetic mutation renders biotin-responsive carboxylase enzymes much less able to bind with biotin cofactor due to markedly decreased affinity. Supraphysiologic doses can restore normal enzyme function

Lactic acidosis caused by low-dose metformin: Thiamine HCL 100mg followed by 75mg TTFD long-term, normalization of all liver values (2014) I gave thiamine a try (Thiamine Mononitrate) 50 mg but after a couple of days, I had some bad reaction to the product (tachycardia, worst dysautonomia upon standing). I was surprised because the dose is fairly minimal compared to those of other patients (some take north of 1g). I was wondering if this is the kind of paradox you have seen in the past? Do you think it is due to the mononitrate part of the product or thiamine itself? Should I try thiamine HCL instead? cases of perceptive deafness, 20 cases of laryngeal disease, 7 cases of facial nerve palsy and 3 cases of anosmia injected with TTFD 50mg once per day for 5-20 days. 60% effective and no side effects. I don’t want to be a part of a clinical trial; I want to know, I am taking the real thing and not a placebo; I want to try more than one thing(s) at time. Pyridoxine induced cell death in a concentration-dependent way in SHSY5Y cells. The other vitamers did not affect cell viability. […] “Moreover, both pyridoxal-5-phosphate dependent enzymes were inhibited by pyridoxine. In conclusion, the present study indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-5′-phosphate. Consequently, symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.”I do know that I was feeling a lot better on the Lipothiamine and wondering whats the best course now in terms of supplementation given my situation. I have been self-treating chronic health issues for a long time and have made great progress thanks to internet podcasts, groups, videos and blogs. I now have what feels like the one last hurdle and I'm hoping B1 is the missing piece.