Durga Anumolu, P. et al. Quantification of linagliptin by chemical derivatization with appliance of chromogenic. J. Appl. Chem. Res. 11(2), 39–50 (2017). Scientific, research, navigation, surveying, photographic, cinematographic, audiovisual, optical, weighing, measuring, signalling, detecting, testing, inspecting, life-saving and teaching apparatus and instruments; Sri, K. V. V., Anusha, A. & Sudhakar, M. UV-spectrophotometry method for the estimation of linagliptin in bulk and pharmaceutical formulations. Asian J. Res. Chem. 9(1), 47 (2016). Widely Compatibility: TEGELI PD 20W USB C Charger plug is compatible with iPhone 14/13/13 pro/13 pro max /iPhone 12 / 12 Pro / 12 Pro Max / 12 Mini / 11/11 Pro / 11 Pro Max / 11 Mini / 10/10 Max / iPhone 8 / iPhone 7 / iPhone 7 plus / iPhone 6s / iPhone 6, Samsung Galaxy S21 / Galaxy S21 + / Galaxy S21 ultra / Galaxy S20 / Galaxy S10 / Galaxy S9 / Galaxy S8 / Note / Tab / A series.

The TEGELI trademark was assigned an Application Number # UK00003730999 by the UK Intellectual Property Office (UKIPO). apparatus and instruments for recording, transmitting, reproducing or processing sound, images or data; Badugu, L. R. A validated RP-HPLC method for the determination of linagliptin. Am. J. Pharm. Tech. Res. 2(4), 463–470 (2012). Ntoi, L. L. A. & Von Eschwege, K. G. Spectrophotometry mole ratio and continuous variation experiments with dithizone. Afr. J. Chem. Educ. 7(2), 59–92 (2017). Chemical and Physical Properties of LNG: color and form: slightly hygroscopic, white to yellow solid. Melting Point: 190–195°C. Solubility: In water, 3.33mg/L at 25°C; soluble in methanol; sparingly soluble in ethanol. Stability: It is stable if stored as directed; avoid strong oxidizing agents 2.

The researcher tested different volumes of HCI 37% (1–3mL), to select the appropriate acidic medium volume for LNG and PDAB reaction. The best results were obtained with 2mL of HCl 37% (Fig. 3c). Selection of temperature

Freeman, M. K. Efficacy and safety of linagliptin (tradjenta) in adults with type-2 diabetes mellitus. J Clin Pharm Ther. 36(12), 807 (2011). The research method which is adopted for this paper was an experimental design that used an analytical approach to explore the research objectives. InstrumentationThe researcher studied the suitable of PDAB volume in the range of 0.5–3mL, to find the suitable volume of PDAB reagent (5% w/v). So, the result had shown that the highest absorption intensity was achieved at a PDAB volume of 1mL then it decreased (Fig. 3b). Evaluation of HCl volume Sri, K. V., Anusha, M. & Reddy, S. R. A rapid RP-HPLC method development and validation for the analysis of linagliptinin bulk and pharmaceutical dosage form. Asian J. Pharm. Anal. 5(1), 16–20 (2015). Aliquots volume of working solution LNG were moved into series of 10mL volumetric flasks to perform final concentrations of 5–45ppm. To each flask was added 1mL of ρDAB 5% (w/v) and 2mL of HCl 37%, then to the water bath at 70–75° for 35min after closed and shaking very well, after those flasks were cooled and diluted to 10mL by distilled water. The maximum absorption of the yellow color was 407nm upon the blank. The amount of linagliptin was calculated from the calibration curve. CHMP. Trajenta-Assessment Report-Committee for Medicinal Products for Human Use (CHMP) (Eur Med Agency, 2011). Mourad, S. S., El-Kimary, E. I., Hamdy, D. A. & Barary, M. A. Stability-indicating HPLC-DAD method for the determination of linagliptin in tablet dosage form: Application to degradation kinetics. J Chromatogr. Sci. 54(9), 1560–1566 (2016).

Linagliptin—PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Linagliptin#section=Structures, Accessed 19 Jan 2022.Preparation of ρDAB (2 × 10 –3mol/l) solution by dissolving 29.8mg in 100mL of methanol with good shaking, was freshly prepared. Barapatre, S. R., Ganorkar, A. V. & Gupta, K. R. Quality by design-based HPLC assay method development and validation of linagliptin in tablet dosage form. Eur. J. Pharm. Med. Res. 4(02), 486–494 (2017). Fda, Cder, Beers, Donald. Analytical Procedures and Methods Validation for Drugs and Biologics Guidance for Industry (2015). Rajbangshi, J. C., Alam, M. M., Hossain, M. S., Islam, M. S. & Rouf, A. S. S. Development and validation of a RP-HPLC method for quantitative analysis of linagliptin in bulk and dosage forms. Dhaka Univ. J. Pharm. Sci. 17(2), 175–182 (2018).