Guo J., Qin Y. T., Zhu Y. F., Zhang X. F., Long C., Zhao M. T., Tang Z. Y., Chem. Soc. Rev., 2021, 50, 5366 Yi J. D., Xie R. K., Xie Z. L., Chai G. L., Liu T. F., Chen R. P., Huang Y. B., Cao R., Angew. Chem. Int. Ed., 2020, 59, 23641

Ferguson ND, Frutos-Vivar F, Esteban A, et al. Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study. Crit Care. 2007;11(5):R96. Sinufuu T, Kahnamoui K, Cook DJ, et al. Rationing critical care beds: a systematic review. Crit Care Med. 2004;32:1588–97.Takeda K, Wada A, Yamamoto K, Moriyama Y, Aoki K (1989) Conformational change of bovine serum albumin by heat treatment. J Protein Chem 8:653–659 A reduction of the transcriptional activity of NF‐κB was apparent in both Panc Tul and BxPC3 cell lines by the change in expression of cyclin D1 and Bcl2. This is testimony to the functional relevance of NF‐kB inhibition by GP‐2250. The expression of cyclin D1, the driver of cell cycle progression, was reduced by GP‐2250 (Figure 5). This finding is in line with the previously shown reduction of the rate of cell proliferation by GP‐2250. 1 The expression of the anti‐apoptotic protein Bcl2 was likewise reduced by GP‐2250 (Figure 6). Thus, by inhibiting NF‐κB, GP‐2250 is able to disrupt tumour progression in a two‐pronged manner, by reducing the rate of cell proliferation and promoting apoptosis. Liu L. L., Zhou X. J., Guo L. X., Yan S. J., Li Y. J., Jiang S., Tai X. S., Rsc Adv., 2020, 10, 33417 Yamazaki Y., Mori K., Kuwahara Y., Kobayashi H., Yamashita H., ACS Appl. Mater. Interfaces, 2021, 13, 48669 Orr K. W. P., Collins S. M., Reynolds E. M., Nightingale F., Bostroem H. L. B., Cassidy S. J., Dawson D. M., Ashbrook S. E., Magdysyuk O. V., Midgley P. A., Goodwin A. L., Yeung H. H. M., Chem. Sci., 2021, 12, 4494

Kim S, Ohulchanskyy TY, Pudavar HE, Pandey RK, Prasad PN (2007) Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. J Am Chem Soc 129:2669–2675 Data on adult patients receiving MV for at least 3 days in ICUs or non-ICU settings from April 2010 through March 2012 were obtained from the Quality Indicator/Improvement Project, a voluntary data-administration project covering more than 400 acute-care hospitals in Japan. We excluded patients with cancer-related diagnoses. Patient demographic data and the critical care provided were compared between groups. Results Ghosh S, Dey J (2015) Binding of fatty acid amide Amphiphiles to bovine serum albumin: role of amide hydrogen bonding. J Phys Chem B 119:7804–7815Note that you may use our state-of-the-art calculator above to obtain the quotient of any two integers or whole numbers, including 2250 and 3, of course. Zhao M. T., Yuan K., Wang Y., Li G. D., Guo J., Gu L., Hu W. P., Zhao H. J., Tang Z. Y., Nature, 2016, 539, 76

Han B., Li T. B., Zhang J. Y., Zeng C. B., Matsumoto H., Su Y., Qiao B. T., Zhang T., Chem. Commun., 2020, 56, 4870 Li G, Magana D, Dyer RB (2014) Anisotropic energy flow and allosteric ligand binding in albumin. Nat Commun 5:3100 Iwashita Y, Sanui M, Imai H. An attitude survey on doctors treating critically ill patients in hospitals without ICU facilities. J Jpn Assoc Acute Med. 2016;27:175–83.

Reduce 2250/3 to lowest terms

Liu H. L., Chang L. N., Bai C. H., Chen L. Y., Luque R., Li Y. W., Angew. Chem. Int. Ed., 2016, 55, 5019 Andrade CD, Yanez CO, Ahn H-Y, Urakami T, Bondar MV, Komatsu M, Belfield KD (2011) Two-photon fluorescence vascular bioimaging with new bioconjugate probes selective toward the vascular endothelial growth factor receptor 2. Bioconjug Chem 22:2060–2071