Chiltern Railways 3-car Class 165/0 unit Great Western Railway 3-car Class 165/1 unit Named units [ edit ] The Class 165/1 fleet were built for local services from London Paddington along the Great Western Main Line; their main destinations included local trains to Reading, Greenford, Newbury, Bedwyn, Oxford, and Banbury, and services along the branch lines to Windsor & Eton Central, Henley-on-Thames, Marlow and Bicester Town. System Data for Mechanical and Electrical Coupling of Rail Vehicles in support of GM/RT2190 (PDF). London: Rail Safety and Standards Board. 22 June 2011. p.4. SD001. Archived from the original (PDF) on 1 April 2012 . Retrieved 22 November 2022. In 2012, First Great Western took delivery of Class 180 Adelante units for Cotswold Line services, and three-car Class 150 Sprinter units for Reading to Basingstoke Line services, allowing Class 165 and 166 units to be used to reinforce Thames Valley services. [14] The terms UIP and IPF have become more narrowly defined since they were originally proposed several decades ago ( 5, 65). The relationship between historically defined IPF (or lone CFA) and UIP has been described in an ATS Consensus Statement entitled “Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment” ( 60). According to the current definition, IPF is a distinctive type of chronic fibrosing interstitial pneumonia of unknown cause limited to the lungs and associated with a surgical lung biopsy showing a histologic pattern of UIP ( 60). In the presence of a surgical biopsy showing a UIP pattern the diagnosis of IPF requires ( 1) exclusion of other known causes of interstitial lung disease including drug toxicities, environmental exposures, and collagen vascular diseases, ( 2) characteristic abnormalities on conventional chest radiographs or high-resolution computed tomography (HRCT) scans as described below ( 60), and ( 3) abnormal pulmonary function studies showing restriction (reduced total lung capacity [TLC], or reduced vital capacity [VC] with a normal or increased FEV 1/FVC ratio) and/or impaired gas exchange [increased P( a–a)O 2 (alveolar–arterial pressure difference for O 2), decreased Pa O 2 with rest or exercise, or decreased D l CO (diffusing capacity of the lung for CO)].

The differential diagnosis for LIP includes diffuse lymphoid hyperplasia (hyperplasia of bronchial mucosa-associated lymphoid tissue [MALT]), nodular lymphoid hyperplasia, lymphoma (of mucosal-associated lymphoid tissue or small lymphocytic types), and the patterns of OP, NSIP, hypersensitivity pneumonitis, and UIP ( 89). Diffuse lymphoid hyperplasia without alveolar septal infiltration has been included under the category of LIP in previous studies ( 151). Although there may be some overlap in these patterns, for the purposes of this classification the term LIP is limited to those cases with extensive alveolar septal infiltration ( 147).The interobserver variability of pathological interpretation, particularly among general pathologists, needs to be defined.

The histologic differential diagnosis for cases of NSIP showing a fibrosing pattern includes the UIP pattern and fibrotic forms of other types of interstitial pneumonitis, including hypersensitivity pneumonitis, Langerhans' cell histiocytosis, DIP, organizing pneumonia, DAD, and sarcoidosis ( 17, 21, 23, 89). The most important difference between the fibrosing pattern of NSIP and UIP patterns is the temporal uniformity of the former, which contrasts with the variegated appearance of the connective tissue in the UIP pattern, in which dense collagen is associated with scattered fibroblastic foci. In most cases, the distinction between the cellular and fibrosing patterns of NSIP is not difficult. In some cases, the presence of dense interstitial fibrosis may be highlighted with connective tissue stains (e.g., the Masson trichrome stain or Movat stain). NSIP is an area of uncertainty that requires further definition. The panel recommended that the use of the term NSIP be considered as a provisional diagnosis until there is further clarity on the nature of the corresponding clinical condition. Under the auspices of the ATS, a multidisciplinary panel is reviewing clinical cases of NSIP from around the world. When published (expected in late 2002), this review will be used to better characterize this entity and to determine its relationship to IPF, hypersensitivity pneumonitis, COP, DIP, and LIP.Unit 165128 was in service as a hybrid unit with 58609 (MOS vehicle from 166209) inserted in the middle from November 2015 until May 2016. This was due to one of its driving vehicles being damaged in an engine fire on the North Downs line in November 2015, [ clarification needed] rendering it out of service, and so to provide another 3-car train in service. [11] Chapple, James (16 November 2015). "Passengers 'standing around in country lane' after train fire". Surrey Live. A new depot was built at Aylesbury in 1990/1991 for the maintenance of these trains and has been enlarged since British Rail days, with the addition of a wheel lathe. Light maintenance and refuelling is carried out at Wembley LMD and Tyseley TMD, and units can occasionally be found at Stourbridge LMD. Units are also regularly stabled in the Marylebone station environs, Aylesbury South Sidings and at Banbury, where a further depot is currently under construction at the south end of the station on the western side of the line.