Tmax (or the time taken to achieve the maximum concentration) in one clinical study of healthy patients receiving 50 mg/kg of fluconazole was 3 hours. Flukem is a very selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. This enzyme normally works to convert lanosterol to ergosterol, which is necessary for fungal cell wall synthesis. The free nitrogen atom located on the azole ring of fluconazole binds with a single iron atom located in the heme group of lanosterol 14-α-demethylase. This prevents oxygen activation and, as a result, inhibits the demethylation of lanosterol, halting the process of ergosterol biosynthesis. Methylated sterols are then found to accumulate in the fungal cellular membrane, leading to an arrest of fungal growth. These accumulated sterols negatively affect the structure and function of the fungal cell plasma membrane. If the mucus layer is excessive, we advise dosing with Chloramine T at 15g per 1000 gallons, 24 hours before using Fluke M, this will assist in reducing the mucus membrane where body flukes can sometimes get trapped. The Fluke 170 Series of digital multimeters have the features needed to find most electrical, electro-mechanical, and heating and ventilation problems.

Ans : This medication is advised to be consumed orally. The salts involved in this medication react properly if it is taken after having food. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it. Irregular or fast heart rate, palpitations, seizures or fainting, indicating Torsades de Pointes (a condition of abnormal rhythm of the heart which may cause a sudden cardiac arrest)This product is designed as a one off treatment, but may require a second dose after 7 days in heavy infestation. Alternatively you can use Fluke M or Fluke S after 7 days. Flukem is contraindicated in people with pre-existing medical conditions like Liver Disease as it can result in adverse effects. Other conditions have been mentioned below in the Flukem contraindications section. Flukem 150 MG Tablet is primarily prescribed for the treatment of hepatosplenic candidiasis and other Candida infections, cryptococcal infections and secondary prophylaxis for cryptococcal meningitis in persons with AIDS. It is also used as antifungal prophylaxis in allogeneic bone marrow transplant recipients.

Flukem is a prescription drug, available for use as Tablet. It is primarily used for the treatment of Fungal Infections, Candidal Infection, Urinary Tract Infection. Other than this, Flukem has some other therapeutic uses, which have been discussed ahead. The apparent volume of distribution is said to be similar to the volume of distribution of total body water. One clinical study of healthy volunteers administered 50 mg/kg of fluconazole was 39L, based on a body weight of 60kg. Dose adjustment is needed in patients with renal impairment. Consult your doctor before taking Flukem 150 MG Tablet. Dosing adjustment/interval in renal impairment: There are no sufficient and well-controlled studies of fluconazole use in pregnant women. Available human data do not show an increased risk of congenital anomalies after pregnant women were treated with standard doses (27 Several case reports describe rare but striking congenital anomalies observed in infants who were exposed to fluconazole at high doses reaching 400-800 mg/day, primarily in the first trimester of pregnancy. Similar findings were observed in animal studies. If this drug is administered during pregnancy, or if the patient becomes pregnant while taking fluconazole, the risk should be discussed thoroughly.

Flukem

Flukem overdoses have been associated with hallucination and paranoia, sometimes in combination. In cases of overdose, employ supportive treatment. Gastric lavage may be necessary. Other modalities such as forced diuresis or hemodialysis may also be used. Yellowing of the skin, dark urine, light-coloured stool and itchiness of the skin, indicating liver damage If you have missed a dose of FLUKEM 150MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose. Do not double the dose of FLUKEM 150MG TABLET to make up for the missed one as this may increase the chances of developing side effects. Keep out of the reach of children and pets. If swallowed seek medical advice. Wash any contamination from eyes immediately.