Witting M, et al. (2015). Interactions of hyaluronicacid with the skin and implications for the dermal delivery of biomacromolecules.DOI: Hyaluronic acid injections into the skin or joints have a higher risk of side effects. However, negative reactions are mostly associated with the injection procedure, rather than hyaluronic acid itself ( 1). Summary However, more large, high-quality studies are needed to understand the effects of oral hyaluronic acid supplements on eye health. Summary Another older study showed that the same type of supplement was five times more effective at reducing acid reflux symptoms than a placebo ( 30). Allergy to avian or avian-derived products: HA may be derived from rooster combs. Caution is advised if you have an allergy to eggs, feathers, or poultry. In addition to obtaining HA from animals, HA can also be obtained from bacteria.

Having the unique ability to attract and hold up to 10,000 times its molecular weight in water, it is key to keeping our skin soft, plump and hydrated. Taking hyaluronic acid supplements may prevent this decline by giving your body extra amounts to incorporate into the skin ( 4, 5). It also aids skin’s collagen production, which helps to keep skin elastic and bouncy, and so gives a more youthful look to your appearance.https://www.arthritis.org/living-with-arthritis/treatments/medication/drug-types/other/hyaluronic-acid-injections.php

Some research shows that pairing oral hyaluronic acid supplements with injections can help extend pain-relieving benefits and increase the amount of time between shots ( 26). Summary

Improving the water content in the skin strengthens its barrier, calms irritation and (temporarily) plumps out fine lines. "It also helps to repair inflammation, damage and environmental stress," she adds. "The immediate cosmetic effect is amazing too – it's wonderful under make-up." HA in its original state and molecular weight carries no risks of irritation (although you will, of course, need to consider how your product was formulated, and the other ingredients inside it). Are all hyaluronic acids equal? Hyaluronic acid in aqueous solutions self-associates to form transient clusters in solution. [39] While it is considered a polyelectrolyte polymer chain, hyaluronic acid does not exhibit the polyelectrolyte peak, suggesting the absence of a characteristic length scale between the hyaluronic acid molecules and the emergence of a fractal clustering, which is due to the strong solvation of these molecules. [39] Biological synthesis [ edit ] However, as we age, the amount we store in our bodies decreases - by the age of 50, it’s possible that your body’s Hyaluronic Acid reserves will have decreased by 50%. The anti-aging effects of hyaluronic acid products may vary from person to person, depending on other factors that influence the skin, such as:

However, its effects during pregnancy or breastfeeding have not been thoroughly studied, so these groups should be cautious and avoid supplementing with it. Pavicic T, et al. (2011). Efficacy ofcream-based novel formulations of hyaluronic acid of different molecularweights in anti-wrinkle treatment.

What is hyaluronic acid?

Ortonne J. (1996). A controlled study of the activity of hyaluronic acid in the treatment of venous leg ulcers. DOI: Taking 80–200 mg daily for at least 2 months has been shown to significantly reduce knee pain in people with osteoarthritis, especially those between the ages of 40 and 70 years old ( 23, 24). Liguori V, et al. (1997). Double-blind,randomized clinical study comparing hyaluronic acid cream to placebo inpatients treated with radiotherapy.