However, vitamin B6 deficiency is thought to be rare in most healthy adults, so there is limited research on using B6 to treat anemia. PLP is required for the conversion of tryptophan to niacin, so low vitamin B 6 status impairs this conversion. [15] Magne B6 is a medicine to help supplement magnesium and vitamin B6 for the body, the drug is indicated in the condition of magnesium deficiency. So what disease does Magne B6 medicine treat and how to use it? Tablet form: Take from 6 to 8 tablets per day, divided into 2 to 3 times. Tube form: Drink 3-4 ampoules per day, divided into 2 to 3 times. Dosage of Magne B6 in children:

PLP is involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis and function, and gene expression. PLP generally serves as a coenzyme (cofactor) for many reactions including decarboxylation, transamination, racemization, elimination, replacement, and beta-group interconversion. [2] [3] [15] Amino acid metabolism [ edit ] Established magnesium deficiency – isolated or combined, which can be expressed by any of the following symptoms: Jayedi A, Zargar MS (2019). "Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies". Crit Rev Food Sci Nutr. 59 (16): 2697–707. doi: 10.1080/10408398.2018.1511967. PMID 30431328. S2CID 53430399.Dietary Reference Values for vitamin B6". EFSA Journal. 14 (6): e04485. 2016. doi: 10.2903/j.efsa.2016.4485. ISSN 1831-4732. While it appears that high doses of vitamin B6 supplements may provide anti-inflammatory benefits for people with rheumatoid arthritis over time, more research is needed. A randomized controlled trial in 158 healthy adults who had siblings with heart disease divided participants into two groups, one that received 250 mg of vitamin B6 and 5 mg of folic acid every day for two years and another that received a placebo ( 31). Vitamin B 6 is a water-soluble vitamin, one of the B vitamins. The vitamin actually comprises a group of six chemically related compounds, i.e., vitamers, that all contain a pyridine ring as their core. These are pyridoxine, pyridoxal, pyridoxamine, and their respective phosphorylated derivatives pyridoxine 5'-phosphate, pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate. Pyridoxal 5'-phosphate has the highest biological activity, but the others are convertible to that form. [9] Vitamin B 6 serves as a co-factor in more than 140 cellular reactions, mostly related to amino acid biosynthesis and catabolism, but is also involved in fatty acid biosynthesis and other physiological functions. [1] [2] [3] Forms [ edit ]

Studies have linked low levels of vitamin B6 with anemia, especially in pregnant women and women of childbearing age ( 20, 21). Mei N, Guo X, Ren Z, Kobayashi D, Wada K, Guo L (January 2017). "Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports". J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 35 (1): 1–28. doi: 10.1080/10590501.2016.1278298. PMC 6373469. PMID 28055331. Isoniazid is an antibiotic used for the treatment of tuberculosis. Common side effect include numbness in the hands and feet, also known as peripheral neuropathy. [18] Co-treatment with vitamin B 6 alleviates the numbness. [19] a b c d e f "USDA Food Data Central. Standard Reference, Legacy Foods". USDA Food Data Central. April 2018 . Retrieved 18 August 2021.Vitamin B6 may play a role in improving brain function and preventing Alzheimer’s disease, but the research is conflicting. Vitamin B6 has been used to treat symptoms of premenstrual syndrome, or PMS, including anxiety, depression and irritability. These amounts of B6 are significantly higher than the RDA and sometimes combined with other B vitamins. It’s difficult to assess if increasing intake of B6 from dietary sources has the same benefits for certain conditions that supplements may provide. Ulvik A, Midttun Ø, Pedersen ER, Eussen SJ, Nygård O, Ueland PM (July 2014). "Evidence for increased catabolism of vitamin B-6 during systemic inflammation". The American Journal of Clinical Nutrition. 100 (1): 250–5. doi: 10.3945/ajcn.114.083196. PMID 24808485.

Fanidi, A; Muller, DC; Yuan, J; Stevens, VL; Weinstein, SJ (January 2018). "Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3)". Journal of the National Cancer Institute. 110 (1): 57–67. doi: 10.1093/jnci/djx119. ISSN 1460-2105. PMC 5989622. PMID 28922778. The group that took B6 and folic acid had lower homocysteine levels and less abnormal heart tests during exercise than the placebo group, putting them at an overall lower risk of heart disease ( 31). Another study compared the impact of ginger and vitamin B6 on reducing episodes of nausea and vomiting in 126 pregnant women. The results showed that taking 75 mg of B6 each day decreased nausea and vomiting symptoms by 31% after four days ( 29). As of 2019, fourteen countries require food fortification of wheat flour, maize flour or rice with vitamin B 6 as pyridoxine hydrochloride. Most of these are in southeast Africa or Central America. The amounts stipulated range from 3.0 to 6.5mg/kg. An additional seven countries, including India, have a voluntary fortification program. India stipulates 2.0mg/kg. [31] Dietary supplements [ edit ]a b Schorgg P, Bärnighausen T, Rohrmann S, Cassidy A, Karavasiloglou N, Kühn T (May 2021). "Vitamin B6 Status among Vegetarians: Findings from a Population-Based Survey". Nutrients. 13 (5): 1627. doi: 10.3390/nu13051627. PMC 8150266. PMID 34066199. a b c d e f g Parra M, Stahl S, Hellmann H (July 2018). "Vitamin B 6 and Its Role in Cell Metabolism and Physiology". Cells. 7 (7): 84. doi: 10.3390/cells7070084. PMC 6071262. PMID 30037155. A three-month study in over 60 premenopausal women found that taking 50 mg of vitamin B6 daily improved PMS symptoms of depression, irritability and tiredness by 69% ( 23). Czégény G, Kőrösi L, Strid A, Hideg E (February 2019). "Multiple roles for Vitamin B 6 in plant acclimation to UV-B". Scientific Reports. 9 (1): 1259. Bibcode: 2019NatSR...9.1259C. doi: 10.1038/s41598-018-38053-w. PMC 6361899. PMID 30718682.