In conclusion, the results of this study has demonstrate that at rest, menthol cooling gel increases cutaneous blood flow and cooling sensation alongside reduced intramuscular and skin temperatures, which was also shown in the placebo and ice conditions. Immediately following treatment measurements of skin and intramuscular temperature, cutaneous blood flow and a visual thermal comfort scale 17 were taken and repeated every 10 minutes. However, the likely cause was from evaporative cooling despite menthol-derived increases in cutaneous blood flow and cooling sensation. Cold therapy is widely used to reduce the amount of soft tissue damage following an acute injury 1 and has been proposed to reduce inflammatory response, haematoma, oedema and pain.

Ice packs reduced intramuscular temperature, alongside cutaneous blood flow, to a greater extent than both gels immediately following treatment but was similar by 80 minutes. Menthol is an ingredient that activates Transient Receptor Potential Melastatin 8 (TRMP8) channels which are non–selective and are known to also open in response to cold temperature (8-28 °C). The leg to be treated was randomly selected, by also using Excel, on the first visit but kept the same for the remaining two visits.Please consult your doctor before taking any new product, particularly if you are already under medical care.

The quantity of gel used for each participant was measured by weighing the gel tube twice for pre and post treatment.Then femoral arterial blood flow was recorded using a 10-MHz multifrequency linear array transducer attached to a high- resolution ultrasound machine (Sonosite, M Turbo, FUJIFILM SonoSite, Inc. The lotion contains shea butter, aloe, and vitamin E; the scent of Vicks® contains eucalyptus, menthol, and camphor.