Romanelli, F., Smith, K. M., Thornton, A. C., & Pomeroy, C. (2004, January). Poppers: Epidemiology and clinical management of inhaled nitrite abuse [Abstract]. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 24(1), 69–78 Some experts suggest that using poppers may lead to risky sexual activity, increasing the chances of contracting HIV.

For example, research in rats indicates that the chemicals in poppers may be toxic to the brain and inhibit learning and memory.It is OK to inhale poppers, but it is not OK to inhale poppers directly from the bottle. If you are in a well-ventilated room and breathe it in, then no harm will be done. Just like any other room aroma, it has been made specifically to alleviate sour smells and make a room habitable again. It is OK to inhale poppers – just don’t sniff poppers directly from the bottle. More on that in a moment.

People typically use poppers for a pleasurable feeling of intoxication or euphoria, but some find the experience unpleasant and disorientating.Pantalone, D. W., Bimbi, D. S., Holder, C. A., Golub, S. A., & Parsons, J. T. (2010, October). Consistency and change in club drug use by sexual minority men in New York City, 2002 to 2007 [Abstract]. American Journal of Public Health, 100(10), 1892–1895

Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.A bottle of poppers will last for a very long time. We advise our clients to get a new bottle either when the scent starts to wear off, or when it has evaporated. Poppers room aroma will slowly dissipate into the air. At some point, it may be that you stop smelling it because the activator (that’s the ingredient that makes the poppers smell) stops working. This usually takes about three months of uncorked use. First, let’s talk about how to use poppers safely and then move on to an example of how not to use our high-quality poppers products. If you choose to use poppers in any other way, then we suggest you do not take anything illegal. Alcohol is a primary replacement. At least if you drink or inhale alcohol in excessive quantities the medics will be well-versed in taking care of you. If you don’t use poppers correctly, we cannot guarantee the same. We also recommend that learning how to sniff poppers should be confined to the method outlined above. It has been said in the past that those wondering how to sniff poppers are doing it the wrong way.