The Preface outlines how to use the monographs and basic drug dosing advice including valuable information on the use of estimated glomerular filtration rate (eGFR). The use of drugs in patients with impaired renal function can give rise to problems for several reasons: Welcome to the The Renal Drug Database. The information contained in this resource has been compiled from a wide range of sources and from the clinical experience of the editorial board of the UK Renal Pharmacy Group, all of whom are involved in the pharmaceutical care of renally-impaired patients. As such, some of the information contained in the monographs may not be in accordance with the licensed indications or use of the drug.

The RCGP have produced an AKI Toolkit to disseminate learning from AKI cases. Medicines Learning Portal Physical Examination Procedures for Advanced Practitioners and Non-Medical Prescribers - 2nd ed. (2015) individual medicine monographs on how to prescribe, prepare and administer the medicine in various types of renal impairment Pharmaceutical Preformulation and Formulation: a Practical Guide from Candidate Drug Selection to Commercial Dosage Form - 2nd ed. (2009)The information contained within The Renal Drug Database is validated and governed by the UK Renal Pharmacy Group (UKRPG). For further information in the UKRPG, including its aims, events and activities, please visit: www.renalpharmacy.org.uk Altered pharmacokinetics of some drugs, i.e. changes in absorption, tissue distribution, extent of plasma protein binding, metabolism and excretion. In renal impairment these parameters are often variable and interrelated in a complex manner. This may be further complicated if the patient is undergoing renal replacement therapy. provide a practice-based review of drug utilisation in renal units across the UK indicating, where appropriate, any local methods of use, licensed or otherwise. Biologics, Biosimilars and Biobetters: An Introduction for Pharmacists, Physicians and other Health Practitioners(2021)

One limitation is that the handbook is a UK publication so some of the drugs and dosing recommendations are not relevant to the Australian situation. Perhaps a consideration for future editions might be to include some general comments on the use of various drug classes in patients with renal disease. Blood Results in Clinical Practice: A Practical Guide to Interpreting Blood Test Results - 2nd ed. (2019) Physicochemical Principles of Pharmacy in Manufacture, Formulation and Clinical Use - 6th ed. (2016) The Renal Drug Database (subscription required) is available online and as a handbook. Both contain:A universally-trusted resource, this edition of The Renal Drug Handbook contains over 800 drug monographs comprising prescribing information for clinical and medicines information pharmacists. Caroline Ashley is the Lead Specialist Pharmacist for Renal Services at the University College London Centre for Nephrology and Transplantation, Royal Free Hospital. She has nearly 25 years' renal experience, and her major areas of interest are transplantation and auto-immune renal disease. Caroline was involved in the development of the Renal National Service Framework, and the NICE guidelines on Immunosuppression in Renal Transplantation, Renal Anaemia, and Acute Kidney Injury. She is the co-editor of both The Renal Drug Handbook and the Introduction to Renal Therapeutics, and sits on the editorial board of the British Journal of Renal Medicine. She has been the Chair of the UK Renal Pharmacy Group since 1996, and was made Associate Professor of Pharmacy Practice, UCL School of Pharmacy in 2011. The Renal Drug Database is not intended to offer definitive advice or guidance on how drugs should be used in patients with renal impairment, nor is it a comprehensive and complete list of all drugs licensed in the UK.

provide healthcare professionals with a single reference of easily retrievable, practical information relating to drug use, sourced from the practical experience of renal units throughout the UK. By referring to the monographs, the user is guided in how to prescribe, prepare and administer the drug with due regard to potentially serious drug interactions and to any renal replacement therapy the patient may be undergoing. Caroline Ashley is the Lead Specialist Pharmacist for Renal Services at the University College London Centre for Nephrology and Transplantation at the Royal Free Hospital. She has over 25 years' experience, with major interests in transplantation and auto-immune renal disease. Caroline was involved in the development of the Renal National Service Framework, and the NICE Guidelines on Immunosuppression in Renal Transplantation, Renal Anaemia and Acute Kidney Injury. She is the co-editor of The Renal Drug Handbook, The Renal Drug Database and The Introduction to Renal Therapeutics and sits on the editorial board of the British Journal of Renal Medicine. She was Chair of the Uk Renal Pharmacy Group from 1996 to 2016, and was made Associate Professor of Pharmacy Practice, UCL School of Pharmacy in 2011. In addition to our own resources, we recommend the following resources for information about specific medicines in renal impairment.

Footnotes

Launched in 2014, The Renal Drug Database comprises all monograph information from the highly successful The Renal Drug Handbook, the universally-trusted resource for pharmacists seeking definitive prescribing information when treating patients with renal impairment.

The BNF is rarely used as a sole information source for managing medicines in renal impairment. Renal Drug Handbook and Renal Drug Database Full access to over 800 drug monographs that comprise concise information on clinical use, dosing, important drug interactions, metabolism and drug administration. contains pharmacokinetic data to inform how the medicine will be removed, e.g. amount of parent medicine excreted through the kidneys, how any active metabolites are removed, impact of kidney disease on medication half-life CRC Press publishes medical books across a wide range of therapy areas including Toxicology, Pharmaceutical Science, Infectious Disease, Oncology, Nephrology, Gastroenterology and Hepatology. CRC Press authors and editors are among the leaders in medical science, and many of our publications document the notable contributions they have made to their own specialist fields. You can find details about all our books by visiting https://www.crcpress.com/medicineFor many drugs, some or even all of the altered pharmacokinetic parameters and modified interrelationships are unknown. In such circumstances, the informed professional judgement of clinicians and pharmacists must be used to predict drug disposition. This must be based on knowledge of the drug, its class, chemistry and pharmacokinetics in patients with normal renal function.