Patients aiming to reduce cigarettes/e-cigarettes should use the Mouthspray between smoking/vaping episodes, as needed, to prolong smoke/vape-free intervals and to reduce their use as much as possible. Diabetes mellitus: Patients with diabetes mellitus should be advised to monitor their blood sugar levels more closely than usual when quitting, and NRT is initiated as reductions in nicotine induced catecholamines released by nicotine can affect carbohydrate metabolism. Directions: For adults and children 12 years and over. It is important to use enough nicotine spray to control cravings. Use 1 spray first when you would normally smoke/vape, or have cravings to smoke/vape. If your cravings do not disappear within a few minutes use a second spray. If 2 sprays are required to control cravings, future doses may be delivered as 2 consecutive sprays. Do not use more than 2 sprays per dose or 4 sprays per hour or 64 sprays per day. Care should be taken not to spray the eyes. If you get spray in your eyes rinse thoroughly with water. Do not inhale whilst spraying to avoid getting spray down your throat.

Nicotine should be avoided during breast-feeding The relatively small amounts of nicotine found in breast milk during NRT use are less hazardous to the infant than second-hand smoke. Intermittent dose forms would minimize the amount of nicotine in breast milk and permit feeding when levels were at their lowest. It is important to use enough nicotine spray to control cravings, and using 1 or 2 sprays corresponds to the nicotine from a cigarette. Use one spray first and if your cravings do not disappear within a few minutes use a second spray. If 2 sprays are required to control cravings, future doses may be delivered as 2 consecutive sprays. For many smokers this means about 1-2 sprays every 30 minutes to 1 hour. Nicorette® are at the forefront of Nicotine Replacement Therapy (NRT) innovation, offering a range of products to suit your needs including, nicotine gum, nicotine patches, nicotine inhalators and nicotine chewing gum to help you to quit smoking. Upon first time use, point the nozzle away and press the top of the dispenser several times until a fine spray appears. If spray is not used for 2 days or more, this may need to be repeated.AUC∞ estimates show the bioavailability of nicotine administered by mouth spray is somewhat higher than that of nicotine gum or lozenge. The AUC∞ of the mouth spray 2 mg measured 18.9 h*ng/mL as compared with 16.2 h*ng/mL for nicotine gum 2 mg. Allowing for differences in administered dose, bioavailability was also higher in a second study. The nicotine AUC∞ of the mouth spray 2 mg measured 14.0 h*ng/mL in comparison with 23.0 h*ng/mL and 26.7 h*ng/mL for and nicotine gum 4 mg and nicotine lozenge 4 mg, respectively. When you stop smoking or vaping, you may notice unpleasant feelings alongside a strong desire to smoke or vape– this is known as a craving. This is because your body starts to miss the nicotine it was getting from cigarettes and vapes.

A maximum concentration of 5.3 ng/mL is reached within 13 minutes after administration of a 2 mg dose. The nicotine AUCs over the first 10 minutes after administration of the mouth spray at a dose of 1 and 2 mg exceeds those of nicotine gum as well as nicotine lozenge at doses of 4 mg (0.48 and 0.64 h*ng/mL vs. 0.33 and 0.33 h*ng/mL). Care should be taken not to spray the eyes. If you get spray in your eyes rinse thoroughly with water. Do not inhale whilst spraying to avoid getting spray down your throat. Ideally, you should aim to stop smoking. However, it can be used in many different ways, either to completely replace all your cigarettes or if you do not feel ready to stop smoking completely, to replace certain cigarettes and therefore help you cut down the number of cigarettes you smoke. It may also help increase your motivation to quit. The nicotine withdrawal effects of vaping cessation have not been established, however it is anticipated that many of the effects relating to nicotine withdrawal will be the same as those seen with tobacco smoking cessation.

Although the frequency in the active group is less than that of the placebo group, the frequency in the specific formulation in which the PT was identified as a systemic ADR was greater in the active group than the placebo group. Note: phones may not be able to read a NFC chip when the camera is open, when NFC based mobile pay (such as Apple pay, Samsung pay) is in use or in Airplane mode.