Plaque contains bad germs that can metabolise sugar to produce acids, in turn these acids cause mineral loss and weaken the teeth. The power of arginine lies in the fact that it helps feed the good flora and weaken the effects of the bad germs, allowing the new formula to offer clinically proven enamel protection with 4x more enamel strengthening power*. Fiorillo L, Cervino G, Herford AS, Laino L, Cicciù M. Stannous Fluoride Effects on Enamel: A Systematic Review. Biomimetics (Basel). 2020;5(3):41. doi:10.3390/biomimetics5030041 Nayak PA, Nayak UA, Khandelwal V. The effect of xylitol on dental caries and oral flora. Clin Cosmet Investig Dent. 2014;6:89-94. doi:10.2147/CCIDE.S55761

When determining the best toothpastes, we spoke with dentists and spent hours reviewing dozens of toothpastes from the top oral care brands. These experts include: Recently, there has been a growing interest in natural products. People's interest has been shifted from synthetic toothpaste to herbal toothpaste. Herbal toothpaste does not contain any artificial colors or flavors that many of the regular toothpaste have. Artificial colors and flavors of the toothpaste are also giving birth to many diseases and health-related issues. The demand for herbal toothpaste suppliers has risen due to the great advantages which are associated with this toothpaste type. There are a number of brands of herbal toothpaste on the market. Abhaibhubejhr is a widely known herbal-based toothpaste containing Guava leaves, Betel vine leaves, and Mangosteem peel for which medicinal properties are claimed. However, many of the health claims made for them have not been clinically proven. Dental calculus or tartar is calcified deposit occurring on the teeth or other solid structures in the oral cavity such as restorations, prosthetic appliances, and dental implants. Calculus is calcified dental plaque which can be classified as supragingival or subgingival calculus. Dental plaque is the diverse community of microorganisms found on tooth surface as a biofilm. The microorganisms bind tightly to one another and the tooth surface by means of an extracellular matrix of polymers of host and microbial origin.[ 1 , 2] Dental plaque biofilms are responsible for many common oral diseases including dental caries, gingivitis, periodontitis, and peri-implantitis.[ 3]Most fluoride-based toothpastes contain a concentration of at least 1,000 parts per million (ppm) of fluoride. For people with severe tooth decay, a dentist may recommend a toothpaste with a concentration of up to 5,000 ppm. If you have any special dental needs—for example bleeding gums or sensitive teeth—you should choose a toothpaste formulated for that reason. Many people who fall into this category find traditional toothpastes too harsh for their needs. When you’re shopping for toothpastes, you want to make sure that you are looking for ingredients that make you healthier,” says Erinne Kennedy, DMD, a dentist and spokesperson of the American Dental Association (ADA). Dr. Kennedy also recommends looking for active ingredients like fluoride and hydrogen peroxide, which will keep your mouth clean and free from disease. Surfactant: Most Americans are accustomed to sudsy toothpaste. Sodium lauryl sulfate (SLS) creates the foaming action in conventional toothpastes. Some dentists believe it helps to clean teeth and the mouth more thoroughly. Guava leaf contains essential oils, flavonoids, tannins, eugenol, saponins, triterpenes, malic acid, and phenolic acid.[ 18] The potential pharmacologic activities of the extract from guava leaf have been reviewed including antimicrobial, antioxidant, anti-allergy, anti-genotoxic, anti, antiplasmodial, antispasmodic, cardioactive, cough suppressant, antidiabetic, anti-inflammatory, antinociceptive, and antiplaque.[ 19] It has been reported that the extract of guava leaf reduced the adherence of early plaque bacteria to an experimental pellicle.[ 20] Razak and Rahim,[ 21] in 2006, also found that treatment of the early plaque settlers with aqueous guava extract reduced the cell-surface hydrophobicity of Streptococcus sanguinis, Streptococcus mitis, and Actinomyces sp. The extract was observed to have the ability to alter and disturb the surface characteristics of the early plaque settlers and make them less adherent leading to its potential as an antiplaque and anticalculus agent.

Betel leaf contains volatile oil (eugenol, cadinene, carvacrol, caryophyllene, chavitbetol, chavicol, estragole, amino acids, pyridine alkaloids, sitosterols, tannins, stigmasterol, Vitamin C, oxalic acid, malic acid, and inorganic elements like fluoride and iron).[ 16] Further betel leaf possesses anti-bacterial, anti-cariogenic, anti-inflammatory, antifungal, antiprotozoan, anti-allergic, antidiabetic, hepatoprotective, anti-ulcer, cardioprotective, antihyperlipidemic, anti-platelet, and immunomodulatory properties.[ 17] Those patients with sensitive teeth should look for brands like Sensodyne that incorporate potassium nitrate into their toothpaste formulas, as potassium nitrate helps to soothe inflamed nerves,” Dr. Kunen suggests. If you're unsure which toothpaste will best fit your individual needs, ask your dentist for guidance. Inclusion characteristics included good general health, male and female subjects, aged 18–70, inclusive, scoreable lower six anterior teeth free of large restorations or dental prosthetic crowns, a Volpe-Manhold calculus index score of at least 10, and available for the 20-week duration of the study. Fluoride has been a key component of toothpaste for over 50 years, targeting the tooth itself to help make it stronger and working by helping to prevent mineral loss and enhance mineral gain by being incorporated into the tooth as fluorapatite. However, it has proven to help protect against cavities to an extent, but not enough to eradicate them. With the incorporation of arginine, Colgate has established a toothpaste technology that targets the true cause of cavities, the plague germs, a technological advance that should be considered the new gold standard for cavity protection worldwide. Abrasives: “Toothpastes may also contain calcium carbonate, silicate aluminum carbonates, or aluminum hydroxide; those things are abrasives,” says Dr. Manz. “I think most of the data really indicates that the action of the bristles of the toothbrush on our tooth is what really removes the majority of the plaque in the calculus.” These are cleaning and polishing agents added to toothpaste to remove surface stains and break up bacterial colonies. According to the ADA, toothpaste with a relative dentin abrasion of 250 or below is safe to use for daily brushing with appropriate techniques. FlavorsFluoride: This is the single most important ingredient in conventional toothpaste. “Fluoride is going to be the primary active ingredient,” says Dr. Manz. Dr. Kennedy adds, "[Sodium fluoride] is a safe way to strengthen your teeth and to prevent tooth decay or cavities.” As the global leader in Oral Care we continue to be committed to making the best scientific and technology advances available to all Pretest phase: Oral soft/hard tissue and calculus examination, oral prophylaxis and toothpaste use at home This study was approved by the Faculty of Dentistry, Mahidol University Institutional Review Board (COA. No.MU-DT/PY-IRB 2012/016.1204). Adult subjects from the Faculty of Dentistry, Mahidol University, Thailand, signed an informed consent form and were screened by the examining dentist to identify those subjects who meet the inclusion characteristics and demonstrate a tendency to form calculus. The first 150 subjects who meet the inclusion/exclusion were entered into the pretest phase of this double-blind, randomized, parallel clinical study.