In some cases, users simply cannot tolerate curcumin as a dietary supplement and need to avoid taking it. In other cases, there may be some viable explanations behind their reported side effects. If you’re experiencing side effects from curcumin supplementation, consider the factors that may be contributing to the severity and/or number of side effects including: curcumin dosage, co-administered substances, term of administration, metabolism, and source. Sahoo JP, et al. (2020). Turmeric (haldi) — a strapping strategy for enhancing the immune system to reduce the effect of SARS-CoV-2. Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease. Characterized by the overabundance of a highly active fibroblast population (Amara et al., 2010; Strieter & Mehrad, 2009), this fatal lung disease claims the lives of an estimated 41,000–82,000 people annually in Europe and the United States (Hutchinson et al., 2014). This is of particular concern for the world’s aging population as the incidence increases significantly with age (Raghu et al., 2006). The importance of this for developed countries cannot be overstated as the elderly population is expected to double over the next 25 years (Mora et al., 2017). Currently, a number of drugs are at various stages of development, but only two drugs have received FDA approval for the treatment of IPF (Mora et al., 2017). Another curcumin absorption study conducted by Antony et al. showed the effects of a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO) and a curcumin–lecithin–piperine over a curcumin control in 11 healthy volunteers in a cross-over design with a 3-week wash-out period [ 34]. For the analytical method, an internal standard was not applied, resulting in determination of curcumin alone in the blood for up to 8 h after administration. As a result, the formulation showed a 6.9-fold increased absorption over control, whereas in this study, a much lower increase with approximately 30% relative absorption of CEO was demonstrated. In our study, we have compared four different commercially available curcumin formulations and analysed their pharmacokinetic profile in 12 subjects in a randomized, double-blind, cross-over study over a 12-h time period.

Look for products that are manufactured in CGMP-compliant facilities and tested for purity and potency, ideally by a third-party organization such as: However, BioSchwartz Turmeric Curcumin Capsules is one of the best rated because it’s relatively affordable, is formulated with piperine for enhanced bioavailability, and can be divided into two or three doses throughout the day for optimal absorption.

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is made by a company that provides objective measures of trust, such as having its supplements validated by third-party labs Ikeda S, Uchida T, Ichikawa T, Watanabe T, Uekaji Y, Nakata D, Terao K, Yano T (2010) Complexation of tocotrienol with gamma-cyclodextrin enhances intestinal absorption of tocotrienol in rats. Biosci Biotechnol Biochem 74(7):1452–1457. doi: 10.1271/bbb.100137 If you’re interested in adding more curcumin to your diet, the easiest way is to eat more turmeric. Many Southeast Asian and Middle Eastern cuisines regularly incorporate turmeric into their recipes. Since curcumin isn’t well-researched, it is possible that even low doses provoke nausea in certain individuals. In some cases, the nausea may be moderate and/or severe to the extent that an individual feels like vomiting or as if they have the flu. If you’re experiencing severe nausea from curcumin, you may need to simply accept the fact that you’re unable to tolerate it as a supplement. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

If you’ve been supplementing with curcumin, especially at high doses, it is possible that you may encounter some unwanted side effects. The two most common side effects associated with curcumin supplementation include: diarrhea and nausea. Below is a comprehensive list of possible side effects that you may experience while supplementing with curcumin. Keep in mind that the severity and number of side effects you experience is likely subject to significant individual variation. Also understand that some individuals supplementing with curcumin may not experience any noticeable side effects. This may trigger intense stomach pain, and in worse cases, stomach ulcers. If you have gallstones or suspect that you may, verify the safety of curcumin supplementation with your doctor and beware of this potentially adverse effect. You don’t want to run the risk of worsening gallstone problems and/or biliary obstruction; this will cause intense pain. This is another side effect stemming from curcumin’s propensity to irritate the gastrointestinal tract. To reduce the likelihood of flatulence associated with supplementation, consider a dosage reduction and be sure to avoid taking curcumin on an empty stomach. In most cases, the increase in flatulence as a result of curcumin supplementation should be considered minimal. Jager R, Lowery RP, Calvanese AV, Joy JM, Purpura M, Wilson JM (2014) Comparative absorption of curcumin formulations. Nutr J 13:11. doi: 10.1186/1475-2891-13-11Chandran B, Goel A (2012) A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res PTR 26(11):1719–1725. doi: 10.1002/ptr.4639 The dosage of your curcumin supplement may have a major impact on whether you’re likely to experience side effects from supplementation. Many low-dose curcumin users won’t notice any significant side effects, whereas high-dose curcumin users often report at least one or two side effects. When taking higher doses, there’s more overall curcumin that will undergo metabolism, distribution, and excretion – meaning it has greater influence over your physiology. In extreme cases, users have reported blisters along with the rash. It is unclear as to whether these blisters resulted directly from the curcumin, or whether they were a result of excessive skin scratching by the user. Obviously if you have a severe skin rash, it is imperative to seek immediate medical help as to rule out other potential causes and ensure your own safety.