Some drugs may have Authority Required (Streamlined) status which does not require an explicit approval from Medicare, instead the doctor can use the Authority code found in the published Schedule for a given drug/indication. El Zahrawi – Father Of Surgery". Archived from the original on September 27, 2007 . Retrieved May 4, 2007. Between 400 and 1200 CE, Arab traders introduced opium to China, and to India by 700. [19] [1] [12] [20] The physician Muhammad ibn Zakariya al-Razi of Persian origin ("Rhazes", 845–930 CE) maintained a laboratory and school in Baghdad, and was a student and critic of Galen; he made use of opium in anesthesia and recommended its use for the treatment of melancholy in Fi ma-la-yahdara al-tabib, "In the Absence of a Physician", a home medical manual directed toward ordinary citizens for self-treatment if a doctor was not available. [21] [22] Heroin, the first semi-synthetic opioid, was first synthesized in 1874, but was not pursued until its rediscovery in 1897 by Felix Hoffmann at the Bayer pharmaceutical company in Elberfeld, Germany. From 1898 to 1910 heroin was marketed as a non-addictive morphine substitute and cough medicine for children. Because the lethal dose of heroin was viewed as a hundred times greater than its effective dose, heroin was advertised as a safer alternative to other opioids. [104] By 1902, sales made up 5 percent of the company's profits, and "heroinism" had attracted media attention. [105] Oxycodone, a thebaine derivative similar to codeine, was introduced by Bayer in 1916 and promoted as a less-addictive analgesic. Preparations of the drug such as oxycodone with paracetamol and extended release oxycodone remain popular to this day. [ citation needed]

Description of the Culture of the White Poppy and Preparation of Opium, as Practised in the Province of Bahar". The Asiatic Journal and Monthly Miscellany. Vol.3. Wm. H. Allen & Company. 1817 . Retrieved May 31, 2022. Ms Louise Foxcroft (June 28, 2013). The Making of Addiction: The 'Use and Abuse' of Opium in Nineteenth-Century Britain. Ashgate Publishing, Ltd. pp.66–. ISBN 978-1-4094-7984-0. Peters, Gretchen. Seeds of Terror: How Heroin is Bankrolling the Taliban and Al Qaeda, Thomas Dunne Books (2009).

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Latimer, Dean, and Jeff Goldberg with an Introduction by William Burroughs. Flowers in the Blood: The Story of Opium. New York: Franklin Watts, 1981 Parrott A, Morinan A, Moss M, Scholey A. Understanding drugs and behaviour. West Sussex: John Wiley & Sons Ltd; 2004.

John K. Fairbanks, "The Creation of the Treaty System' in John K. Fairbanks, ed. The Cambridge History of China, vol. 10 Part 1 (Cambridge University Press, 1992) p. 213. cited in John Newsinger (October 1997). "Britain's opium wars – fact and myth about the opium trade in the East". Monthly Review. Archived from the original on February 13, 2006.

Opium contains two main groups of alkaloids. Phenanthrenes such as morphine, codeine, and thebaine are the main psychoactive constituents. [153] Isoquinolines such as papaverine and noscapine have no significant central nervous system effects. Morphine is the most prevalent and important alkaloid in opium, consisting of 10–16 percent of the total, and is responsible for most of its harmful effects such as lung edema, respiratory difficulties, coma, or cardiac or respiratory collapse. Morphine binds to and activates mu opioid receptors in the brain, spinal cord, stomach and intestine. Regular use can lead to drug tolerance or physical dependence. Chronic opium addicts in 1906 China [48] consumed an average of eight grams of opium daily; opium addicts in modern Iran [154] are thought to consume about the same. Ouchterlony, John (1844). The Chinese war: an account of all the operations of the British forces from the commencement to the Treaty of Nanking. London: Saunders and Otley. Abu Bakr Muhammad ibn Zakariya al-Razi (841–926)". Saudi Aramco World. January 2002 . Retrieved January 12, 2008.