The results of the risk of bias assessment are detailed in Additional File 2: Tables S5-6 and Additional File 3: Fig. S7-12. The overall risk of bias was low to high for the indices included in the meta-analyses. The high risk of bias was caused mainly by the baseline differences between interventional and control groups regarding some of the diversity indices [ 50, 53]. Probiotics are defined as microorganisms that provide benefits to their host. Humans rely on resident microorganisms, including probiotics, to keep our bodies healthy and functioning properly, but diet and other factors can alter our healthy bacteria. Koo H, Hakim JA, Crossman DK, Kumar R, Lefkowitz EJ, Morrow CD. Individualized recovery of gut microbial strains post antibiotics. Biofilms Microbiomes. 2019;5:1–6. verifyErrors }}{{ message }}{{ /verifyErrors }}{{ Qian XB, Chen T, Xu YP, Chen L, Sun FX, Lu MP, et al. A guide to human microbiome research: Study design, sample collection, and bioinformatics analysis. Chin Med J (Engl). 2020;133:1844–55.

Herboxa obsahuje ideální kombinaci probiotik a jejich vyživy (prebiotika), které zajišťují rychlejší zotavení normálních střevních funkcí a aktivity. Since probiotics must make it through the stomach to be effective 3 , the beneficial properties of a probiotic product depend on its survival in a harsh, acidic environment. Physician’s Choice delayed-release capsules are acid-resistant, offering a critical layer of protection to keep the probiotic organisms viable on their journey to the intestines 4*. Our acid-resistant vegetable capsules delay the release of probiotics to protect them from the harsh acidity of your stomach. This ensures maximum survivability and allows the friendly microbes to release deeper in your digestive tract. Maximum potency The main strength of the study is the high level of evidence for our quantitative results as we included only randomized controlled trials in our review and meta-analysis. Moreover, to our knowledge, this is the first meta-analysis and the most comprehensive review of the topic to date. We followed the strict guidelines of Cochrane recommendations [ 18] and PRISMA Statement [ 19] when performing our systematic review and meta-analysis, which is strengthening our results.Roswell M, Dushoff J, Winfree R. A conceptual guide to measuring species diversity. Oikos. 2021;130:321–38.

PRO biotika jsou živé mikroorganismy s výhodnými účinky vůči zdraví. Často se označují za "přítelské" nebo "dobré" bakterie, které podporují imunitní systém, střeva a celkové zdraví. Existují přirozeně v trávícím traktu a pomáhají chránit proti škodlivým bakteriím a plísním. This is the first meta-analysis and the most comprehensive review of the topic to date using high quality methods. The limited number of studies and low sample sizes are the main limitations of our study. Moreover, there was high variability across the studies regarding the indication of antibiotic therapy and the type, dose, and duration of antimicrobials and probiotics. ConclusionsGupta VK, Kim M, Bakshi U, Cunningham KY, Davis JM, Lazaridis KN, et al. A predictive index for health status using species-level gut microbiome profiling. Nat Commun. 2020;11:4635. Some of the included articles suggested that probiotic supplementation during antibiotic therapy has a protective effect on Blautia and Roseburia spp. levels [ 50, 54, 61]. Recently, Blautia has been associated with the alleviation of inflammatory and metabolic diseases by regulating host health, and it has also been characterized by antibacterial activity [ 76]. Gut Roseburia spp. produce short-chain fatty acids, modulate colonic motility, support immunity, and have anti-inflammatory effects [ 77]. These findings suggest that probiotic supplementation may have some benefits but the tendency for Blautia levels to normalize spontaneously after antibiotic discontinuation casts doubt on them [ 52]. Implication for practice and research

The PICO-S format (population, intervention, comparison, outcome, and study design) was used to formulate our clinical question and establish the eligibility criteria. We included all the studies that met the following eligibility criteria: population (P) — people treated with antibiotics regardless of indication; intervention (I) — probiotic supplementation along with antibiotic treatment; comparison group (C) — no probiotic supplementation. The assessed outcomes (O) were gut microbial diversity and composition (any diversity indices reported) at the end of the intervention and after a follow-up period, as reported in each study. No restrictions were applied regarding sex, age, ethnicity, or associated comorbidities. Only randomized controlled trials (RCTs) were included. Our probiotic contains 60 billion live and active microbes in each serving at the time of manufacturing. This high-potency formula allows a greater chance of healthy microbes colonizing in your gut. We ensure maximum concentration and effectiveness with zero unnecessary binders, GMOs, gluten, colors, preservatives, or other additives. Synergistic supportWhen your microbiome is unbalanced, you can experience many digestive issues, including bloating, indigestion, and diarrhea. 60 Billion Probiotic can help combat occasional digestive issues by restoring balance to your gut. Boosts nutrient absorption However, there is also evidence that taking low doses of single-strain probiotics for shorter periods is most effective.

Spolu s dobře známými kmeny obsahuje naše speciální složení také zejména odolné kmeny, které dokáží vydržet žaludeční kyseliny.Escherichia coli and Enterococcus family species are commensal inhabitants of the gastrointestinal tract that may become pathogens in a dysbiotic environment for several diseases, such as antibiotic-associated diarrhea, vomiting, or permanent intestinal inflammation. Moreover, they are characterized by antibiotic resistance [ 72, 73]. Probiotic supplementation seems to reduce Escherichia overgrowth during antibiotic therapy according to Kabbani et al. and Oh et al. [ 43, 61]. Nevertheless, the level of both Escherichia and Enterococcus tends to normalize after antibiotics cessation regardless of probiotics supplementation. This brings the efficacy of probiotics in preventing this type of antibiotic induced dysbiosis into question [ 52, 59, 61]. Li, B., et al. (2020). Efficacy and safety of probiotics in irritable bowel syndrome: A systematic review and meta-analysis.