Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. View abstract. Boning, Charles R. (2006). Florida's Best Fruiting Plants: Native and Exotic Trees, Shrubs, and Vines. Sarasota, Florida: Pineapple Press, Inc. pp.166–167.

Carica papaya was the first transgenic fruit tree to have its genome sequenced. [30] In response to the papaya ringspot virus outbreak in Hawaii in 1998, genetically altered papaya were approved and brought to market (including 'SunUp' and 'Rainbow' varieties.) Varieties resistant to PRV have some DNA of this virus incorporated into the plant's DNA. [31] [32] As of 2010, 80% of Hawaiian papaya plants were genetically modified. The modifications were made by University of Hawaii scientists, who made the modified seeds available to farmers without charge. [33] [34] One study in rats given a medication to induce toxicity found that papaya seed extract helped prevent kidney damage ( 8). antioxidant and immunostimulant effect of Carica papaya Linn. aqueous extract in acrylamide intoxicated rats Papaya is a fantastic component to moisturize your skin. Adding honey to papaya offers better hydration, and keeps your skin supple and smooth. Both papaya and milk are good for exfoliation and make your skin clean and fresh. 2. For Oily SkinMarotta, F., Pavasuthipaisit, K., Yoshida, C., Albergati, F., and Marandola, P. Relationship between aging and susceptibility of erythrocytes to oxidative damage: in view of nutraceutical interventions. Rejuvenation.Res 2006;9(2):227-230. View abstract. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3. View abstract.

Papaya is a rich source of antioxidants, like lycopene, that help to reduce the visible signs of aging. According to a 2017 study, antioxidants present in papaya can help to combat free radical damage, which helps to keep your skin smooth and youthful. When applied to the skin: The ripe papaya fruit is possibly safe when applied to the skin or gums for up to 10 days. Applying unripe papaya fruit to the skin is possibly unsafe. Unripe papaya fruit contains papaya latex. This can cause severe irritation and allergic reactions in some people. Pregnancy: Ripe papaya fruit is commonly consumed in foods. Unripe papaya fruit is possibly unsafe when taken by mouth during pregnancy. There is some evidence that unprocessed papain, one of the chemicals found in unripe papaya fruit, might poison the fetus or cause birth defects. Additionally, papayas contain vitamin A and flavonoids like beta-carotene, cryptoxanthin, and lutein. These keep the mucus membranes in the eyes healthy and protect them from damage ( 14).Antithrombocytopenic and immunomodulatory potential of metabolically characterized aqueous extract of Carica papaya leaves Besides papaya fruit, many other parts of the papaya plant are beneficial for the skin. You can get the goodness of papaya in different forms like juice, soap, powder, etc. Let's look at how to get the benefits of papaya in different forms. 1. Fruit Fiber moves through your gastrointestinal tract undigested, adding bulk to your stools to promote regularity. Touted to be one of the ‘silent killers’, high blood pressure can be caused due to lifestyle and dietary factors like high sodium intake and less or no physical activity. Low levels of potassium in the body also lead to high blood pressure. 100 grams of papaya contains 182 mg of potassium, which is an essential mineral to keep your blood pressure under control ( 25).