Last but not least is inositol, a B vitamin that helps make up your cellular membranes,and is super important for helping to support already healthy calcium and insulin levels. However, certain circumstances increase the need for B vitamins, making supplements necessary. People who are pregnant or nursing In people who are pregnant or breastfeeding or chestfeeding — especially those who follow vegetarian or vegan diets — supplementing with a B-complex vitamin is crucial.

When methylation occurs, it has a positive impact on chemical reactions in the body that help regulate detoxification, cardiovascular, neurological and reproductive systems in the body including those related to: Clemesha CG, et al. (2019). ‘Testosterone boosting’ supplements composition and claims are not supported by the academic literature. Niacin: Fact Sheet for Health Professionals. National Institutes of Health Office of Dietary Supplements. Vitamin B12 may be useful in helping to treat canker sores, also known as oral ulcers. A double-blind study found that a B12 ointment relieved pain better than a placebo when used as an adjunctive therapy alongside primary treatment. PMSSuperior - Some individuals are less able to efficiently convert folic acid to methylfolate due to genetic variations in the activity of the MTHFR enzyme, therefore taking methylfolate is a more effective option for everyone

Niacin is a cofactor in the mitochondrial respiratory chain, which produces cellular energy. In the body, niacin is transformed into NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which both play a role in oxidation reduction reactions in cells. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Rembe, J.-D., et al. (2018). Effects of vitamin B complex and vitamin C on human skin cells: Is the perceived effect measurable? [Abstract].For starters, what are methylated B vitamins? Methylated B vitamins are forms of certain B vitamins—such as vitamin B12 and folate—that your body simply absorbs better. A study in 60 adults with depression showed that treatment with a vitamin B complex for 60 days led to significant improvements in depression and anxiety symptoms, compared with a placebo ( 29). Gao Y, et al. (2016). New perspective on impact of folic acid supplementation during pregnancy onneurodevelopment/autism in the offspring children — A systematic review.