Praise/reward when your puppy does its business. It’s vital that you reward your puppy immediately after and not when you’re already in the house. Don’t feed or water your Blue Heeler puppy two hours before bed. Increase the bathroom breaks if your puppy keeps soiling the crate at night. According to the European Society of Cardiology, medicines designed to thin the blood or treat blood clots can also cause blue toe syndrome. Recreational drugs, such as cocaine, can also trigger the condition. Renal failure A person’s blood carries oxygen from the lungs to every part of their body. Each cell needs oxygen to repair itself and multiply. The blood also brings cells all the nutrients they need and carries away waste products.

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A vascular surgeon inserts a mesh tube, known as a stent, into the affected blood vessel. This holds the vessel open so the blood can get through. Bypass surgery Appleby R, Moghul I, Khan S. Non-alcoholic fatty liver disease is associated with dysregulated bile acid synthesis and diarrhea: A prospective observational study. PLoS One. 2019 Jan;14(1):1-13. doi:10.1371/journal.pone.0211348