Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article Li ZQ, Dan G, Sun ZH, Zhang H, Gui D, Zhang JB, et al. . Immunization of BALB/c mice with Brucella abortus 2308δwbkA confers protection against wild-type infection. J Vet Sci. (2015) 16:467–73. 10.4142/jvs.2015.16.4.467 DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

2 Small Angle Grinder Spare Parts DeWalt D28136 Type 2 Small Angle Grinder Spare Parts

Interferon-inducible transmembrane protein 3 (IFITM3) belongs to the family of IFN-stimulated genes (ISGs) ( 15) that are key antiviral effectors of the host innate immune system ( 16). Research has indicated that IFITM3 is also a major immune molecule in the host defense against Mtb infection ( 17). The reduction of pH value in lysosomes of host cells mediated by IFITM3 can effectively inhibit the intracellular proliferation of Mtb, suggesting that IFITM3 not only participates in antiviral immunity but also plays a crucial role in inhibiting the survival of intracellular bacteria ( 17, 18). The results from the study of Zhu have shown that IFITM3-containing exosomes were present in the extracellular microenvironment, and that study also determined that these exosomes could transmit the IFITM3-mediated antiviral activity from Dengue virus infected-cells to uninfected cells ( 19), revealing a new mode of antiviral defense. However, in the process of Brucella infection, whether IFITM3-containing exosomes have notable anti-intracellular bacterial activity in hosts is unknown. Maryam K, Zahra S. Exosomes, microvesicles as diagnosis, therapeutic and drug delivery tools. international Pharmacy Acta. (2018) 1:100–1. doi: 10.22037/ipa.v1i1.19968

Conflict of Interest

Please note that Royal Mail will not accept claims for missing parcels until 15 days after posting. Therefore we have to allow this time frame before sending a replacement. Proteome-wide analysis of phospho-regulated PDZ domain interactions. Sundell GN, et al. Mol Syst Biol, 2018 Aug 20. PMID 30126976, Free PMC Article If the Buyer is not personally able to transfer a good and marketable title to Cheffins, then the Buyer shall have no rights under this paragraph 10. The right of return provided by this paragraph 10 is additional to any right or remedy provided by law or by these Conditions of Sale.

Landscape Photography Contest Entry by Daniel Knezevic

Skog J, Würdinger T, Van RS. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. (2008) 10:1470–6. doi: 10.1038/ncb1800 Commission Bids may be left with the Auctioneer by a Bidder indicating the maximum amount to be bid (excluding VAT and Buyers Premium and any other charges which may apply). Subject to the reserve price of the Lot and any other bids received, the sale may be concluded for less than the maximum bid. The Bidder will not have any claim against the Auctioneers or their employees if for any reason the commission bid is not executed. If two bidders submit identical bids, the Auctioneers will endeavour to ensure the first bid received has priority. Smith LM, May RC. Mechanisms of microbial escape from phagocyte killing. Biochem Soc Trans. (2013) 41:475–90. doi: 10.1042/BST20130014 The Auctioneers reserve the right to refuse admission to any person or entry of any Lots in to the Sale without giving any reason. Ahmed W, Zheng K, Liu ZF. Small non-coding RNAs: new insights in modulation of host immune response by intracellular bacterial pathogens. Front Immunol. (2016) 7:431–6. 10.3389/fimmu.2016.00431Mice immunized with exosomes carrying IFITM3 were protected against Brucella infection. Mice immunized… Wang Y, Li H, Xu Z, Yi J, Li W, Meng C, Zhang H, Deng X, Ma Z, Wang Y, Chen C. Wang Y, et al. Microb Biotechnol. 2023 Jul;16(7):1524-1535. doi: 10.1111/1751-7915.14274. Epub 2023 May 22. Microb Biotechnol. 2023. PMID: 37212362 Free PMC article. Keywords: Brucella, exosome, label-free proteomic analysis, IFITM3, immunity, intracellular survival Except where the context otherwise requires words denoting the singular include the plural and vice versa. Words denoting one gender include all genders and words denoting persons include corporations and vice versa. At the Buyer’s request, Cheffins may assist in arranging shipment of Lots. Otherwise collection of Lots is the Buyer’s sole responsibility. Buyers will be required to produce proof of identity on collection of the Lot.

642968 - Gene ResultFAM163B family with sequence similarity

Unless otherwise agreed by the Auctioneers in writing, Cheffins total Liability in respect of any breach of these conditions of sale, or breach of duty, negligence or otherwise (‘collectively Liability’) shall be limited to the Net Sale Proceeds of the relevant Lot and they shall have no liability for Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. (2009) 9:581–93. doi: 10.1038/nri2567 Key Laboratory of Control and Prevention of Animal Disease, Xinjiang Production & Construction Corps, Shihezi, China. Status: VALIDATED Source sequence(s) BX629352 Consensus CDS CCDS35171.1 UniProtKB/Swiss-Prot B2RUZ5, P0C2L3 Related ENSP00000419867.1, ENST00000496132.2 Conserved Domains (1) summary pfam15069 In summary, our data provide the first evidence for the existence of an extracellular vesicle, an exosome carrying IFITM3, which can transmit anti- Brucella activity from one cell to another, thereby effectively inhibiting Brucella infection in the host. This conclusion provides a theoretical foundation for the systematic elaboration of the mechanism of Brucella infection and host immune response, and our findings have provided new ideas for the development of potential candidate vaccines for Brucella. Data Availability StatementMittelbrunn M, Gutiérrez-Vázquez C, Villarroya-Beltri C. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun. (2011) 2:282–8. doi: 10.1038/ncomms1285