Many probiotic strains derive from species with a long history of safe use in foods or from microorganisms that colonize healthy gastrointestinal tracts. For these reasons, the common probiotic species—such as Lactobacillus species ( acidophilus, casei, fermentum, gasseri, johnsonii, paracasei, plantarum, rhamnosus, and salivarius) and Bifidobacterium species ( adolescentis, animalis, bifidum, breve, and longum)—are unlikely to cause harm [ 3]. Sun J, Buys N. Effects of probiotics consumption on lowering lipids and CVD risk factors: a systematic review and meta-analysis of randomized controlled trials. Ann Med 2015;47:430-40. [ PubMed abstract] Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, et al. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014;58:531-9. [ PubMed abstract] A meta-analysis of 30 RCTs with 1,624 participants (mostly adults age 18 years or older) demonstrated that those treated with probiotics for 3 to 12 weeks had 7.8 mg/dL lower total cholesterol and 7.3 mg/dL lower LDL cholesterol concentrations than those treated with placebo [ 54]. In subgroup analyses, the benefits of probiotics were slightly greater in studies that lasted 8 weeks or longer and in participants who had baseline cholesterol levels higher than 240 mg/dL. Among the strains included in more than three studies, Lactobacillus acidophilus, a mixture of Lactobacillus acidophilus and Bifidobacterium lactis, and Lactobacillus plantarum were associated with significant reductions in total and LDL cholesterol concentrations, but Lactobacillus helveticus and Enterococcus faecium were not. In a smaller meta-analysis of 11 RCTs in 602 adults with normal or high cholesterol levels, those treated with probiotics for 2 to 10 weeks had 6.6 mg/dL lower total cholesterol and 8.5 mg/dL lower LDL cholesterol levels than those treated with placebo, but the probiotic treatment had no significant effects on HDL cholesterol levels [ 55]. The effects were most pronounced with consumption of probiotics for more than 4 weeks by participants with hypercholesterolemia and those age 45 or older. In both meta-analyses, participants included both healthy adults and adults with hypercholesterolemia, CVD, diabetes, or obesity. This gives the bad bacteria an opportunity to multiply and grow and may cause side effects such as antibiotic-associated diarrhoea and subsequently lead to permanent changes in the structure and composition of our microbiota.

Probiotic Products deliver a Healthy Gut for a Healthy Life

Certain unfermented foods, such as milks, juices, smoothies, cereals, nutrition bars, and infant and toddler formulas, have added microorganisms. Whether these foods are truly probiotics depends on the microorganism levels they contain when they are eaten, whether they survive intestinal transit, and whether their specific species and strains have health effects. Dietary supplements Overall, the available evidence suggests that starting probiotic treatment with LGG or Saccharomyces boulardii within 2 days of the first antibiotic dose helps reduce the risk of AAD in children and adults age 18 to 64, but not in elderly adults. There is no evidence to suggest that the benefits are greater when more than one probiotic strain is used. Inflammatory bowel disease Iheozor-Ejiofor Z, Kaur L, Gordon M, Baines PA, Sinopoulou V Akobeng AK. Probiotics for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev 2020; 3: Cd007443. [ PubMed abstract] ProVen Probiotics Adult Acidophilus & Bifidus – 25 Billion is a high-strength friendly bacteria supplement for everyday use for adults aged 16+. Supported by a unique body of UK-based clinical research, the Lab4 live bacteria in ProVen Adult 25 Billion is the most comprehensively studied group of friendly bacteria in the UK. Sanders ME. Clinical use of probiotics: what physicians need to know. Am Fam Physician 2008;78:1026. [ PubMed abstract]Ki Cha B, Mun Jung S, Hwan Choi C, Song ID, Woong Lee H, Joon Kim H, et al. The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Gastroenterol 2012;46:220-7. [ PubMed abstract] Ford AC, Quigley EM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol 2014;109:1547-61; quiz 6, 62. [ PubMed abstract] Probiotics are identified by their specific strain, which includes the genus, the species, the subspecies (if applicable), and an alphanumeric strain designation [ 3]. The seven core genera of microbial organisms most often used in probiotic products are Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, Escherichia, and Bacillus. Table 1 shows examples of the nomenclature used for several commercial strains of probiotic organisms. Table 1: Nomenclature for sample commercial strains of probiotics [ 3] Genus Acute diarrhea is usually defined as loose or liquid stools and/or an increase in the frequency of bowel movements (typically at least three in 24 hours) [ 18]. Acute diarrhea can be accompanied by fever or vomiting, and it usually lasts no more than 7 days. Healthy bacteria are required to support both the digestive tract and the urogenital tract in women. For example, most urinary tract infections (UTIs), often referred to as cystitis, are caused by a species of bacteria called Escherichia coli ( E. coli), which generally live happily alongside the good bacteria in the gut and urogenital tract, but can sometimes grow and cause infection.

ProVen Probiotics For Adults – 25 Billion

There are many different types of probiotics that may have different effects on the body, and little is known about which types are best. Assimilation and incorporation of cholesterol into bacteria [ 52], thus lowering cholesterol levels in blood The live microorganisms used to make many fermented foods, including yogurt, typically survive well in the product throughout its shelf life. However, they usually do not survive transit through the stomach and might not resist degradation in the small intestine by hydrolytic enzymes and bile salts and, therefore, might not reach the distal gut [ 7, 8]. However, legitimate probiotic strains contained in yogurt or other foods do survive intestinal transit. Sairenji T, Collins KL Evans DV. An update on inflammatory bowel disease. Prim Care 2017; 44: 673-92. [ PubMed abstract]An assessment of 11 randomized clinical trials with a total of 2,444 participants showed that LGG is most effective in treating infectious diarrhea at a daily dose of at least 10 10 CFU [ 20, 21]. A review of 22 randomized clinical trials with a total of 2,440 participants age 1 month to 15 years found that Saccharomyces boulardii (most commonly 10 9 to 10 10 CFU/day for 5–10 days) reduced both duration of diarrhea and stool frequency [ 22]. In both of these analyses, LGG and Saccharomyces boulardii reduced the duration of acute infectious diarrhea by approximately 1 day. However, two subsequent clinical trials found that a 5-day course of LGG (1x10 10 CFU twice per day taken alone in one trial and a total of 4x10 9 CFU twice per day of LGG and L. helveticus R0052 in the other) was no better than placebo at treating or improving the outcomes of acute gastroenteritis in 1,729 infants and small children presenting to pediatric emergency departments [ 23, 24]. Calcium Carbonate, Fructooligosaccharides, Microorganisms ( Lactobacillus acidophilus CUL60 & CUL21, Bifidobacterium animalis subsp. lactis CUL34, Bifidobacterium bifidum CUL20), Vegetarian Capsule Shell (Hydroxypropyl Methyl Cellulose), Colour (Titanium Dioxide), Ascorbic Acid, Zinc Citrate, Corn Starch, Dicalcium Phosphate, Anti-caking Agents (Silicon Dioxide, Magnesium Stearate), Corn Maltodextrin, Modified Corn Starch, Sunflower Oil, Sucrose, Antioxidants (Sodium Ascorbate, DL-Alpha Tocopherol, Ascorbyl Palmitate), Sodium Selenite, Vitamin D3 (Cholecalciferol). No allergens Supported by a unique body of UK-based clinical research, the Lab4 live bacteria in ProVen Adult 50 Billion is the most comprehensively studied group of friendly bacteria in the UK. Key features