Soderberg O, Hellstrom S. Consequences of using hyaluronan-coated tympanostomy tubes. Acta Otolaryngol Suppl 1987;442:50-3. View abstract. Caitlyn Martyn is a commerce writer on staff at Byrdie, where she covers all things beauty and style. She gathered insights and testimonials from our experienced team of editors and in-house lab testers to curate this list of hyaluronic acid serums that actually do what they say they will. Boccalari E, Tadakamadla SK, Occhipinti C, Lanteri V, Maspero C. Evaluation of the effectiveness of a novel mouth rinse containing hyaluronic acid and hydrogen peroxide on gingivitis: a randomized pilot controlled trial. Clin Exp Dent Res 2022;8(3):673-9. View abstract.

Voigt J., Driver VR. Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials. Wound Repair Regen. 2012;20(3):317-31. View abstract. Kavouni A, Stanec JJ. Human antihyaluronic acid antibodies. Dermatol Surg 2002;28:359-60. View abstract.Nava Greenfield, MD, is a board-certified dermatologist at Schweiger Dermatology Group in Brooklyn, NY. Greenfield is a member of the American Academy of Dermatology, the Women’s Dermatologic Society, and the American Medical Association. With 1.5% hyaluronic acid as the only active ingredient, Kiehl’s Ultra Pure High-Potency 1.5% hyaluronic acid serum is a simple but targeted formula. “I like Kiehl's, and this product has a potent formulation of hyaluronic acid, which is great,” Dr. Salyards says. With 1.5% concentration, it’s right in the range our dermatologists recommend—0.5 to 2.0 percent. Ocak E, Mulazimoglu S, Kocaoz D, Mirici E, Dagli E, Acar A. Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study. J Laryngol Otol 2021;135(6):529-532. View abstract. Torella M, Del Deo F, Grimaldi A, et al. Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women. Eur J Obstet Gynecol Reprod Biol. 2016;207:125-128. View abstract.

Ana Mansouri, MD, is a cosmetic doctor at Kat & Co Aesthetics based in the UK who specializes in injectables and aesthetics. Altman RD. Intra-articular sodium hyaluronate in osteoarthritis of the knee. Semin Arthritis Rheum 2000;30(2 Suppl 1):11-8. View abstract. Although hyaluronic acid works for all skin types, board-certified dermatologist Dr. Nava Greenfield recommends considering your skin type to find the one that suits your needs best. For example, if you have oily skin, she explains, you’ll want to look for a water-based product. We recommend the La Roche-Posay Hyalu B5 Pure Hyaluronic Acid Serum for this. If you have dry skin, she says, try an oil- or cream-based serum for optimal hydration. The Peter Thomas Roth Water Drench Hyaluronic Glow Serum is one of our favorites for very dry skin. Alcohol-Free Formulations

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Petrella RJ, DiSilvestro MD, Hildebrand C. Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med 2002;162:292-8. View abstract. We can attest to the lightweight consistency of this formula. It absorbs immediately and is impressively undetectable once it sinks in. Delia P, Sansotta G, Pontoriero A, et al. Clinical Evaluation of Low-Molecular-Weight Hyaluronic Acid-Based Treatment on Onset of Acute Side Effects in Women Receiving Adjuvant Radiotherapy after Cervical Surgery: A Randomized Clinical Trial. Oncol Res Treat. 2019;42(4):217-223. View abstract. You may have heard a lot in recent years about hyaluronic acid (HA), the wonder ingredient that has found its way into seemingly everything from face creams and foundations to shampoos and eyelash treatments. A brilliant hydrator, hyaluronic acid helps to plump up and retain moisture in the skin, smoothing away fine lines and wrinkles and giving skin a younger, fresher feel.

Frizziero L, Govoni E, Bacchini P. Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: clinical and morphological study. Clin Exp Rheumatol 1998;16:441-9. View abstract. The antioxidant trio of vitamin C, vitamin E, and ferulic acid make this serum suitable for those with oily, acne-prone skin. Our editor with oily skin had never used hyaluronic acid before, but noticed the difference after using this serum for eight weeks. Chen CP, Hung W, Lin SH. Effectiveness of hyaluronic acid for treating diabetic foot: a systematic review and meta-analysis. Dermatol Ther. 2014;27(6):331-6. View abstract. Our editor with dry skin gave this serum a try and had nothing but positive results. It smoothed out fine lines and wrinkles, got rid of some stubborn dry patches, and significantly reduced redness, giving our editor enough confidence to go without makeup. Ruggiero T, Pol R, Camisassa D, et al. Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants. J Biol Regul Homeost Agents. 2016;30(3):889-894. View abstract.Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen 1999;7:79-89. View abstract. Farmacy Filling Good Hyaluronic Acid Serum: A clean option, we like the gentle ingredients in this formula for those with sensitive skin or anyone who actively avoids fragrance, parabens, and the like. We wanted to love it as much as the ingredients list, but at the end of the eight-week testing period, we couldn’t tell much of a difference. Compared to others we tested, this one fell short, though it feels and smells nice. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Even active ingredients that don’t always mix well with others, such as vitamin C and retinol, play nicely with hyaluronic acid. You can use them in the same routine, and hyaluronic acid can even counterbalance any sensitivity or dryness caused by certain active ingredients. The Mad Hippie serum contains quite a few antioxidants along with hyaluronic acid to combine brightening and hydrating benefits. Serati M, Bogani G, Di Dedda MC, et al. A comparison between vaginal estrogen and vaginal hyaluronic for the treatment of dyspareunia in women using hormonal contraceptive. Eur J Obstet Gynecol Reprod Biol 2015;191:48-50. View abstract.