Dr. Brenner illustrated that Niagen promotes NAD generation in the body. On average, taking 300mg per day of Tru Niagen for eight weeks increases NAD levels in the body by 40-50%. On top of that personal experience, we’ve kept up with the evolving picture of NR and NMN science to determine what the best NAD-boosting products are and how Tru Niagen fits into that landscape. All told, we’ve read through more than 100 scholarly articles on NAD, its precursors, and cellular health in general. As scientists have conducted more and more studies, they've discovered numerous, very intriguing things about NAD, including the following:

If this sounds to you like NAD is a potentially important puzzle piece in our understanding of how our health can naturally decline as part of the aging process and our lifestyle decisions, then you're not alone. If our bodies naturally stop producing enough NAD as we age, then our energy production at the cellular level declines, meaning we don't feel the same vigor we used to feel. We'd feel less healthy. And it goes beyond how we feel; the ability of our cells to repair themselves is fundamental to health and wellbeing. Because of this kind of evidence, NAD+ supplements belong squarely in the arena of supplements that are great for older adults, alongside better-known supplements like fish oil , vitamin B12 , and eye vitamins . Navas, L. E., & Carnero, A. (2020). NAD+ metabolism, stemness, the immune response, and cancer. Signal Transduction and Targeted Therapy, 6(1), 1-20. Chu, X., & Raju, R. P. (2022). Regulation of NAD+ metabolism in aging and disease. Metabolism, 126, 154923. Highly effective molecular precursors for NAD+. The precursors we looked for included tryptophan, nicotinamide riboside, nicotinic acid riboside, niacin (also known as vitamin B3), and nicotinamide mononucleotide. As the names suggest, these are all related but different compounds, and all of them can serve as precursors to NAD+ ( 3 ).

Directions

If you feel like you get a boost in NAD+ levels, taking it right away in the morning might be a good idea, but taking it at night is fine, too—safety trials of NAD+ supplements have found no effects on sleep quality ( 5 ). Proponents of NMN point out that it has a dedicated transporter that lives in the small intestine and helps the body take it in to eventually turn it into NAD. 15 Detractors point to an inferior uptake at the cellular level, though the evolution of this science points toward NMN’s ability to penetrate cells after all. Your lifestyle matters too. Stressors and certain lifestyle choices (like maintaining an unhealthy diet and drinking alcohol, for instance) can also deplete your body’s supply of NAD. 17 As a vitamin B3 form, Tru Niagen® contributes to normal energy-yielding metabolism and reduction of tiredness and fatigue. It also contributes to normal psychological function and normal functioning of the nervous system, as well as helping to maintain normal skin and mucous membranes. Directions

Theracurmin is curcumin that has undergone special processes — including wet-mill grinding to reduce its particle size — all to increase its bioavailability. Papers comparing it to unaltered curcumin are scarce, but the company that produces it claims that it’s more than 27 times more bioavailable than standard curcumin extracts. The chief reason that NR supplementation would be good for you is that NR is an NAD precursor in our bodies. In other words, ingesting Niagen replenishes our body's NAD supply. French, S. W. (2016). Chronic alcohol binging injures the liver and other organs by reducing NAD+ levels required for sirtuin's deacetylase activity. Experimental and Molecular Pathology, 100(2), 303-306.McReynolds, M. R., Chellappa, K., & Baur, J. A. (2021). Age-related NAD+ decline. Experimental Gerontology, 134, 110888. Fania, L., Mazzanti, C., Campione, E., Candi, E., Abeni, D., & Dellambra, E. (2019). Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention. International Journal of Molecular Sciences, 20(23). A 2014 study found that NR supplementation protected mice against certain types of liver cancer. 10 NAD allows other beneficial enzymes to work more effectively within the body, such as: 12 Your body’s production of NAD slows down considerably as you age. Human tissue studies demonstrate that our NAD levels decrease by as much as 50% from age 40 onward. 16 If you want to boost your energy production, improve your resistance to the negative effects of obesity, and possibly even sustain better cognitive function into old age, an NAD+ supplement might be able to help.

Dellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., & Marcotulli, E. (2016). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: A randomized, double-blind, placebo-controlled study. NPJ Aging and Mechanisms of Disease, 3. The most highly researched source of NAD in the world, Tru Niagen® has been used in 10 human studies, and many leading universities and institutions globally continue to investigate its benefits. This didn’t necessarily mean they couldn’t have ancillary ingredients with other uses (for example, general-purpose antioxidants), but this did mean that we excluded supplements whose focus was only broadly on anti-aging, or vitamins for older adults that happened to include NAD+-boosting compounds. Nicotinamide mononucleotide (NMN) is a compound that’s incredibly similar to NR, and both have been shown to raise NAD levels in studies. 14 The argument in favor of NMN has to do with absorption, as there’s some disagreement in the scientific community as to which compound — NR or NMN — absorbs better. This strategy works because the NAD+ is bound up with trimethylglycine, a lipid and methyl donor that keeps the NAD+ active.Scientific NAD+ Gold uses NMN, or nicotinamide mononucleotide, to boost NAD+. This compound has demonstrated better performance than nicotinamide when it comes to sustaining high NAD+ levels, at least in animal studies, so it’s a good choice for a sublingual spray. 4. Corllia Liposomal NAD+