a b US 3929677,Hall, John B.&Sanders, James Milton,"Perfume composition and perfume articles containing one isomer of an octahydrotetramethyl acetonaphthone",issued 1975 OTNE is classified as H410 Very toxic to aquatic life with long-lasting effects ( EU-CLP) or R51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment (EU DSD). [7] OTNE is therefore not classified as a PBT or vPvB substance [7] for the EU or any other global criteria. The measured Bio Concentration Factor (BCF) is 391L/kg, which is well below the EU limit of 2000 and US limit of 1000 for Bioaccumulation (B) classification. The LogKow for OTNE has been measured to be 5.65. [7] Iso E Super is a very common perfume ingredient, providing a sandalwood-like and cedarwood-like fragrance, in soap, shampoo, perfumes, detergents, fabric fresheners, antiperspirants or deodorants, and air fresheners. It is also used as a tobacco flavoring (at 200–2000ppm), as a plasticizer and as a precursor for the delivery of organoleptic and antimicrobial compounds. [5] Production [ edit ]

The biodegradation of OTNE in fresh water (T1/2) is at most 40 days, and at most 120 days in sediment (OECD 314 test), though the biodegradation within the 28day window was around 11% (OECD 301-C). Given the outcome of the OECD 314 test OTNE does not meet the criteria for “Persistent” (P) or “very Persistent” (vP).

OTNE has been recommended for inclusion in an update for the EU Fragrance Allergens labelling for cosmetic products based on a small number of positive reactions in dermatological clinics of around 0.2% to 1.7% of patients tested in three studies [18] Iso E Super may cause allergic reactions detectable by patch tests in humans [8] and chronic exposure to Iso E Super from perfumes may result in permanent hypersensitivity. In a study with female mice, Iso E Super was positive in the local lymph node assay (LLNA) and irritancy assay (IRR), but negative in the mouse ear swelling test (MEST). [9] Bester, K. (Nov 2008). "Surface water concentrations of the fragrance compound OTNE in Germany--a comparison between data from measurements and models". Chemosphere. 73 (8): 1366–72. Bibcode: 2008Chmsp..73.1366B. doi: 10.1016/j.chemosphere.2008.06.057. PMID 18715610. The distinction of Iso E Super lies in its design as an aroma-chemical rather than a traditional fragrance. Ordinary fragrances are crafted to project themselves over a wide radius, while Iso E Super is specifically formulated to cling to the skin, effortlessly oscillating between moments of opulence and simplicity. This duality allows it to be at times distinctly noticeable and at other times undetectable, creating an intriguing and ever-changing olfactory experience. The wearer may perceive a subtle, velvety, and woody note that momentarily fades away, only to resurface after some time, enhancing the fragrance's allure and complexity. Iso E Super is produced commercially by Diels–Alder reaction of myrcene with 3-methyl-3-penten-2-one in the presence of aluminium chloride to give a monocyclic intermediate that is cyclized in the presence of 85% phosphoric acid. [6] Synthesis

Discover the captivating nature of Iso E Super, an aroma-chemical that transcends traditional fragrances. Experience the allure of its sweet cedarwood-like scent and embrace the intrigue it brings to both the wearer and those around them.

In 2014 the US National Toxicology Program ( NTP) conducted a 13-week repeat dose toxicity study and found no adverse effects. [17] Stagnant water, charcoal, semen... 10 smells that changed the perfume industry". The Telegraph . Retrieved 2017-06-21. standards library - IFRA International Fragrance Association - in every sense". www.ifraorg.org. Archived from the original on 2015-02-25. Fahlbusch, Karl-Georg; etal. (2007), "Flavors and Fragrances", Ullmann's Encyclopedia of Industrial Chemistry (7thed.), Wiley, pp.45–46