Second degree bums. superficial and deep. If properly applied. no skin grafting IS needed and Regeneration takes place from hair follicles and glands in the dermis and sutx:utaneous tissus. Sponsorship: sponsored by University of Louisville. Statement: "Principal Investigators [PI] are NOT employed by the organization sponsoring the study. There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed."

prespecified outcome, LOS, was not reported for the major burns group. In this group, the outcome was insignificant due to interference from other burns that lengthened the hospital stay. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.Cultures from the wounds revealed polymicrobial infections with at least two micro-organisms, but no anaerobes were found, even though we cannot rule out their presence, which might have been undetected owing to technical faults. MEBO ointment may change its physical appearance during storage. especially during hot seasons. but it does not loose its efficacy. MEBO Ointment Presentation : MEBO is of pure herbal edible origin. No side effects to the product have been reported so far. except for rare allergic reactions to sesame oil. In the study protocol, we planned to restrict the primary analyses to studies at low risk of bias. We defined studies with low risk of bias as RCTs which fulfilled the three criteria of adequate sequence generation, adequate allocation concealment and blinded outcome assessment. However, we conducted a mainly narrative overview, structured by the type of comparison, because statistical meta‐analyses were inappropriate in some cases. This mainly narrative overview was structured by the type of experimental interventions. Three studies reported time to partial wound healing (time to 95% wound healing ( Demling 1999; Wang 2015); time to 90% wound healing ( Demling 2002)); but used no appropriate statistical method (i.e. survival methods for time to event data). Due to differences in study design (unit of analysis (participant versus wounds)) and data presentation (mean versus median), no overall effect estimate was calculated.

The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). Comparison 4: Miscellaneous treatment versus miscellaneous treatment, Outcome 1: Time to wound healingThere is mixed‐certainty evidence that there is no clear difference in time to complete wound healing (no overall effect size available). One study revealed moderate Mafenide acetate cream and gentamicin via iontophoresis (7 participants) vs usual care (mafenide acetate cream) (8 participants) Personal communication; 3 (post‐randomisation) exclusions in MEBO group, because of diabetes. Dropout rate not reported, but complete outcome data likely. ITT analysis unclear.

We planned to perform a meta‐analysis for each primary outcome if clinical and statistical homogeneity indicated this would be appropriate ( Higgins 2003), and calculate summary estimates of treatment effect for every comparison. TransCyte is a bilayered, biologically active, temporary skin substitute with an outer flexible knitted‐nylon layer permeable to water vapour but impermeable to bacteria that decreases environmental insults. The inner layer is impregnated with human fibronectin and collagen Type I.Overall, there is mainly low to very low‐certainty evidence on the effects of any topical intervention on wound healing or infection in people with facial burns. In addition, there is low to very low‐certainty evidence on the effects of the included interventions on need for surgery, pain, scar quality, patient satisfaction, length of hospital stay and side effects. Quote: "Patients lost to follow‐up at 3 months had a shorter hospital length of stay. This was also true at 12 months. At 12 months this was related to percentage total body surface area burned as well." Seven new studies were included ( Hindy 2009; Jiaao 2011; Lehna 2017; Mabrouk 2012; Oen 2012; Tsoutsos 2009; Wang 2015). With the five previously included studies there are now 12 included studies in this review. Time to complete wound healing (number of days for the face wound to heal; number of participants completely healed in 10 days).