The “one-drug-multiple-target” concept is characteristic of the treatment applied for hyperlipidemia. The main targets of berberine on the metabolism of lipids and glucose are IR and the LDLR. Interestingly, berberine has been shown to reduce the serum levels of lipids in humans, hamsters, rats, and mice ( Kong etal., 2004; Chang etal., 2010; Wang etal., 2010). A clinical trial showed that berberine treatment reduced the levels of total cholesterol, triglycerides, and LDL cholesterol, while increasing the levels of HDL cholesterol after 3 months of treatment when compared with a placebo ( Derosa etal., 2013). In particular, a number of observational studies have identified an association between elevated circulating levels of branched-chain amino acids (BCAAs) and poor metabolic health. In clinical studies, increased levels of BCAAs in the blood have been positively correlated with insulin resistance ( Lynch and Adams, 2014). Berberine has been shown to reduce the relative abundance of BCAA-producing bacteria, including Clostridiales; the families of Streptococcaceae, Clostridiaceae, the Streptococcus genera, and Prevotella. Consequently, the increased serum levels of BCAAs induced by the consumption of a high-fat diet are reduced significantly following the administration of berberine. Furthermore, data from both healthy subjects and patients with DM indicate that berberine can improve glycemic control and modulate the circulating levels of BCAAs ( Yue etal., 2019). Therefore, it is evident that the hypoglycemic effects of berberine may be related to improvements in the regulation of gut-derived hormones, the weakening of mechanisms in the intestinal mucosal, and the destruction of the immune-barrier. Kong W., Wei J., Abidi P., Lin M., Inaba S., Li C., et al.. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat. Med. 10 ( 12), 1344–1351. 10.1038/nm1135 It may help reduce LDL, or “bad,” cholesterol and increase high density lipoprotein, or “good,” cholesterol.A meta-analysis found that berberine combined with lifestyle changes works better than lifestyle changes alone in treating high cholesterol. With 600 mg of berberine per capsule, independent lab verification for purity, and no extraneous ingredients, Nuzena is a great choice. High dose, super-pure, and easy to use.

Berberine Supplements of 2023 - The Nutrition Insider The 6 Best Berberine Supplements of 2023 - The Nutrition Insider

Each veggie capsule boasts 600 mg of highly pure and highly concentrated berberine, putting it at the top of our list thanks both to its high dosage and to its high purity. On top of that, its purity is independently verified by third-party lab testing, and it’s certified non-GMO, gluten-free, and vegan-friendly. Guo Y., Zhang Y., Huang W., Selwyn F. P., Klaassen C. D. (2016). Dose-response effect of berberine on bile acid profile and gut microbiota in mice. BMC Complement. Altern. Med. 16 ( 1), 394. 10.1186/s12906-016-1367-7It has the usual 500 mg of berberine per capsule, and the capsules are made of gelatin along with a few extra fillers and stabilizers not found in the competitors, making it hard to justify ranking this supplement any higher. 9. Toniq Berberine Berberine and its derivatives display several pharmacologic effects through various mechanisms ( Jin etal., 2016). Berberine may be therapeutic against various types of chronic diseases, such as obesity, DM, inflammatory bowel disease (IBD), atherosclerosis, Alzheimer’s disease, rheumatoid arthritis, and cardiovascular diseases, due to its multiple-target effects ( Jin etal., 2016). Also, the binding of berberine with histone–DNA complexes can cause interferences in vital cellular processes, such as cell division and cause the death of cancer cells by activating the apoptosis in living cells ( Chen etal., 2016; Hasanein etal., 2017; Roudini etal., 2019). In vitro, berberine has important anti-inflammatory and antioxidant activities.

Berberine: Benefits, supplements, side effects, dosage, and more

A dd to that the fact that it comes in a vegetarian capsule and doesn’t have much in the way of extra fillers and stabilizers, and you’ve got a winning formula for those who need a higher than usual dose of berberine. 7. Naturebell Berberine Plus Organic berberine could be an effective antimicrobial agent. A laboratory studyTrusted Source found that berberine helped inhibit the growth of Staphylococcus aureus.S. aureus can cause many health problems, including sepsis, pneumonia, meningitis, and a range of skin conditions.Another studyTrusted Source found that berberine has the ability to damage the DNA and protein of certain bacteria. Berberine’s potential for controlling blood sugar, blood lipids, and other indicators of your body’s metabolic health is quite strong, making it one of the most exciting herbal supplements on the market right now.Cui H. X., Hu Y. N., Li J. W., Yuan K. (2018. a). Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress. Oxid. Med. Cell Longev. 2018, 8930374. 10.1155/2018/8930374 If you’re looking for a quality weight loss supplement sourced from an herbal remedy, berberine is worth a look. Berberine has also been shown to significantly reduce inflammation, fibrosis, and the levels of lipid peroxides in the liver ( Zhang etal., 2016). The lipid-lowering effect of berberine occurs via a series of continuous events, including bile salt hydrolase (BSH) inhibition, significant increases in the levels of tauro-conjugated bile acids (especially TCA), and the activation of the FXR signaling pathway. These events reduce the expression levels of CD36 in the liver which then leads to a reduction in the hepatic uptake of long-chain fatty acids and the modulation of lipid metabolism in the liver ( Sun etal., 2017). Rats with type 2 diabetes were treated with intragastric administration of 500 mg/kg berberine hydrochloride (BH), berberine fumarate (BF), berberine malate (BM), berberine succinate (BS), and berberine citrate (BC). n = 5, mean ± S.D. * p< 0.05 vs. BH.