Synergistic effects of sub-inhibitory concentrations (<8% w/v) of manuka honey (Comvita, Ltd) and rifampicin on S. aureus biofilm formation and on established biofilms have also been observed in vitro. 24 , 30 Interestingly, some antibiotic combinations (clindamycin, gentamicin and oxacillin) showed an antagonistic effect on S. aureus established biofilms when the honey was used at sub-inhibitory concentrations but not at higher honey concentrations above the MIC (eg, 16% w/v). Physiological and metabolic differences in bacteria within a biofilm could impair the ability of sub-inhibitory concentrations of honey in combination with antibiotics to kill the bacteria.

Activon Tube contains 100% Manuka honey with no additives from New Zealand. Our Manuka honey is filtered and sterilised, making it suitable for application to wounds. Manuka honey will de-bride and de-slough, eliminate odours and provides a moist wound healing environment. Activon Tube is ideal for debriding necrotic tissue, or for topping up dressings where the honey has been washed away by exudate. Great for using in cavities, just wash away with saline solution. How to useActivon Medical Grade Manuka Honey Long-Lasting: Presented in a convenient 25g tube, Activon Tube remains effective for 90 days once opened. There will be high levels of exudate, but this is perfectly normal. It will decrease over time, therefore your secondary dressing of choice may initially need to be super absorbent. For this, the producer of Activon recommends using Eclypse – Super Absorber Dressings. Activon is made by Advancis Medical, a UK based company that was well ahead of the rest of the world and was the first company to introduce medical grade manuka honey in medical products in 2004, since when the product line has expanded to include several wound treatment products. Gel composed of herbal extracts of Acacia catechu, Castanea sativa, Ephedra sinica and Momia combined with honey (25%), maple saps, Phoenix dactylifera (date), pomegranate extract and Azadirachta indica gumDiscomfort can be experienced when honey is applied, depending on sensitivity of the wound it may be necessary to consider an appropriate level of analgesia. The initial discomfort usually subsides, however if it does continue, discontinue use and irrigate the wound with saline solution. How to Use L-Mesitran demonstrated antifungal activity against C. albicans (MIC 25%–50%), whereas 40% Mexican yucatan honey did not.

Zone of inhibition induced by the herbal gel formulation was greater than honey alone (35.1 mm vs 13.1 mm respectively).The various bioactivities of honey work together for a rapid healing — honey rapidly debrides wounds (ie. cleans the wound by releasing pus or dead tissue), kills bacteria, directly suppresses inflammation, and stimulates the growth of the various types of cells involved in the production of new tissue to repair the wound. It will de-bride and de-slough, eliminate odours and provides a moist wound healing environment. Rich in Manuka Honey: Known for its antibacterial and healing properties, this ensures wounds recover faster. Whether the enhanced antimicrobial effects were synergistic, or additive was not determined in this study. Other therapeutic agents being considered for use in combination with honey for the treatment of wounds include honey and bacteriophage therapy, honey supplemented with antimicrobial peptides, honey combined with cyclodextrins or hydrogel, or honey and laser therapy. Novel approaches to wound healing have involved adding a combination of antimicrobial agents to nanofibrous scaffolds. For example, Sarhan and Azzazy (2017) 50 reported that honey (Egyptian clover) (30%) chitosan nanofibers loaded with bee venom (0.01%) and bacteriophages had superior antimicrobial activity in a broth culture assay against MDR P. aeruginosa in comparison to ionic silver containing Aquacel-Ag wound dressing. Furthermore, the novel honey bacteriophage dressing demonstrated better wound healing ability in mice when compared to Aquacel-Ag wound dressing. Oliveira et al (2017) 51 also reported synergistic antimicrobial effects against E. coli biofilms formed on 96 well plates at 12 and 24 hours using multi-floral Portuguese honey and an E. coli specific bacteriophage. This approach combines the antibiofilm effects of honey with the ability of bacteriophages to lyse bacteria. Scanning electron microscopy revealed that honey caused perturbations in the membrane of the E. coli whilst the bacteriophage caused complete lysis with only vesicle structures left behind.

Honey and ginger combination induced higher mean zones of inhibition than honey or ginger alone or standard antibiotic discs (methicillin, penicillin, amoxicillin). Used this on a nasty scald on my husband’s leg... After a week, it's almost completely healed. Now, I’m always using this in the future for broken skin.” - Chris Elliott Activon Tube is 100% pure medical grade manuka honey in a tube. Medical grade manuka honey is natural manuka honey with a very high antibacterial activity that has been sterilized. Activon can be used for treating wounds, burns, scars resulting from surgery, pressure sores, leg ulcers and malodorous wounds.Although the honey is not absorbed into the blood stream, we advise monitoring the levels of patients with diabetes. Versatile Healing Power: Whether it's a human's pressure ulcer or a pet's sore, this tube is your go-to solution.

Twist off the tube cap and apply directly to the wound. If the wound starts to ooze, dress it with an absorbent bandage or dressing after applying Activon Manuka Honey. Activon Tube is ideal for debriding necrotic tissue, or for topping up dressings where the honey has been washed away by exudate. Great for using in cavities, just wash away with saline solution. PROs Hydrogel is commonly used as a wound dressing. It is composed of polymers suspended in water and is thought to provide hydration to a wound and promote healing. El-Kased et al (2017) 53 reported that an Egyptian honey (75%) chitosan hydrogel formula had superior antimicrobial activity against P. aeruginosa, S. aureus, K. pneumonia and Streptococcus pyogenes in a disc diffusion assay in comparison to pure honey. For example, the mean zone of inhibition for the honey 75% chitosan hydrogel formula against S. aureus was 20.2 ± 0.4 vs 15.1 ± 0.9 for honey. This formula was also superior to pure honey in the healing of 10 mm burn wounds induced in mice using a heated metallic rod. The wounds were treated with either the honey 75% chitosan hydrogel formula or honey for 9 days. By day 9, the honey chitosan treated wounds had a mean diameter of 3.8 ± 0.2 mm versus 5.3 ± 0.8 mm in the honey only treated group. Furthermore, an alginate-based honey hydrogel containing thymol-based honey from Damavand, Iran was reported to have superior wound healing ability in rats with infected burn wounds than honey alone. 54 Wound healing was faster in the alginate-based honey hydrogel treated group in comparison to the honey only group. In another study, a paste composed of carboxymethyl cellulose hydrogel (50%), water (30%) and chestnut honey (20%) had superior antimicrobial activity against S. aureus and E.coli in a disc diffusion assay than a paste composed of carboxymethyl cellulose hydrogel (50%) and water only. 55 Furthermore, the paste containing 20% chestnut honey had superior wound healing ability in comparison to the paste without honey in the treatment of wounds inflicted in the dorsal skin of mice. Tavaloki and Tang (2017) 56 designed a wound dressing consisting of a high concentration of honey, polyvinyl alcohol hybrid hydrogel and borax as a crosslinking agent. High concentrations of honey are important for wound healing but can negatively affect the physicochemical properties of hybrid hydrogels. The use of borax apparently overcomes this problem and permits the incorporation of high concentrations of honey without negative effects.Several researchers have explored the effects of combining honey with antibiotics on antimicrobial activity in vitro. One of the first papers reporting a synergistic effect of honey and antibiotics was published in 1998. The researchers used a broth dilution assay to demonstrate a synergistic effect of an Indian honey (obtained from Phondaghat Pharmacy) and the antibiotics amikacin, ceftazidime and gentamicin against multidrug-resistant clinical isolates of P. aeruginosa. 20 The honey and antibiotics were reportedly tested at a ratio of 1:1. Experiments were also conducted with Klebsiella species, but no synergy was observed with this micro-organism. Later in 2005, another study reported synergy using broth dilution method between an Omani honey (50%) and the antibiotic gentamicin (4µg/mL) against Staphylococcus aureus. 21 Additionally, a study conducted in Egypt reported enhanced effects of antibiotics against clinical isolates of P. aeruginosa, Enterobacter species and Staphylococci in a disc diffusion assay when citrus bee honey (100%) was added to the antibiotic discs (Oxoid). 22