Green coffee might decrease how much alendronate the body absorbs. Taking green coffee and alendronate at the same time might decrease the effects of alendronate. Don't take green coffee within two hours of taking alendronate. Selmar, D., Bytof, G., and Knopp, S. E. The storage of green coffee (Coffea arabica): decrease of viability and changes of potential aroma precursors. Ann.Bot. 2008;101(1):31-38. View abstract. Samarrae WA, Truswell AS. Short-term effect of coffee on blood fibrinolytic activity in healthy adults. Atherosclerosis 1977;26:255-60. View abstract. Vinson J, Burnham B. Retraction: Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes 2014;7:467. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC4206203/.

Making coffee from ground raw green coffee beans is simple. Steep the grounds in very hot (not boiling) water for ten minutes, strain and drink. A medium-fine grain produces the best results. Pregnancy and breast-feeding: There isn't enough reliable information to know if green coffee is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use. Chlorogenic acids may also boost fat metabolism, lower cholesterol and triglyceride levels, and improve obesity-related hormone levels. Saito, T., Tsuchida, T., Watanabe, T., Arai, Y., Mitsui, Y., Okawa, W., and Kajihara, Y. Effect of coffee bean extract in essential hypertension. Jpn J Med Pharm Sci 2002;47:67-74.Watanabe T, Arai Y, Mitsui Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 2006;28:439-49. View abstract.

There’s also evidence that the antioxidant-rich chlorogenic acids contained in green coffee can improve insulin sensitivity and treat metabolic syndrome, major causes of diabetes, in prediabetic patients. The effects have been seen in both healthy and obese study participants. Blood Pressure It’s hard to generalize, since varieties of beans and methods of roasting all have an impact. However, roasting coffee beans does slowly lower the amount of caffeine in coffee; dark roast, for example, is less caffeinated than light roast. Glaucoma: The caffeine in green coffee can increase pressure inside the eye, which can make glaucoma worse.Bryant, C. M., Dowell, C. J., and Fairbrother, G. Caffeine reduction education to improve urinary symptoms. Br.J.Nurs. 4-25-2002;11(8):560-565. View abstract. The body breaks down clozapine to get rid of it. The caffeine in green coffee might decrease how fast the body breaks down clozapine. Taking green coffee along with clozapine can increase the effects and side effects of clozapine.