a b c d e f g h Da Silva VR, Gregory III JF (2020). "Vitamin B6". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). Present Knowledge in Nutrition, Eleventh Edition. London, United Kingdom: Academic Press (Elsevier). pp.225–38. ISBN 978-0-323-66162-1. Vitamin B6 may play a role in improving brain function and preventing Alzheimer’s disease, but the research is conflicting. In addition, a review of 19 studies concluded that supplementing with B6, B12 and folate alone or in combination did not improve brain function or reduce the risk of Alzheimer’s ( 18). Map: Count of Nutrients In Fortification Standards". Global Fortification Data Exchange. 16 August 2021 . Retrieved 16 August 2021.

Less severe cases present with metabolic disease associated with insufficient activity of the coenzyme pyridoxal 5’ phosphate (PLP). [1] The most prominent of the lesions is due to impaired tryptophan– niacin conversion. This can be detected based on urinary excretion of xanthurenic acid after an oral tryptophan load. Vitamin B 6 deficiency can also result in impaired transsulfuration of methionine to cysteine. The PLP-dependent transaminases and glycogen phosphorylase provide the vitamin with its role in gluconeogenesis, so deprivation of vitamin B 6 results in impaired glucose tolerance. [1] [15] Diagnosis [ edit ] More research that includes randomized trials and not merely observational studies is needed to assess the exact role of vitamin B6 in cancer prevention.

1. What is Magne B6?

In the US, multi-vitamin/mineral products typically contain 2 to 4mg of vitamin B 6 per daily serving as pyridoxine hydrochloride, but a few contain more than 25mg. Many US dietary supplement companies also market a B 6-only dietary supplement with 100mg per daily serving. [1] While the US National Academy of Medicine sets an adult safety UL at 100mg/day, [1] [4] the European Food Safety Authority sets its UL at 25mg/day. [23] [24] Health claims [ edit ] Research on vitamin B6 and breast cancer also shows an association between adequate blood levels of B6 and a decreased risk of the disease, especially in postmenopausal women ( 37).

Bacteria residing in the large intestine are known to synthesize B-vitamins, including B 6, but the amounts are not sufficient to meet host requirements, in part because the vitamins are competitively taken up by non-synthesizing bacteria. [28]Mei N, Guo X, Ren Z, Kobayashi D, Wada K, Guo L (January 2017). "Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports". J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 35 (1): 1–28. doi: 10.1080/10590501.2016.1278298. PMC 6373469. PMID 28055331. Due to its role in hemoglobin production, vitamin B6 may be helpful in preventing and treating anemia caused by deficiency ( 19). The reason why B6 may help prevent cancer is unclear, but researchers suspect that it’s related to its ability to fight inflammation that may contribute to cancer and other chronic conditions ( 34, 35).

While these results are promising, they’re limited by small sample size and short duration. More research on the safety and effectiveness of vitamin B6 in improving PMS symptoms is needed before recommendations can be made ( 25). A three-month study in over 60 premenopausal women found that taking 50 mg of vitamin B6 daily improved PMS symptoms of depression, irritability and tiredness by 69% ( 23). Studies have linked high blood levels of circulating homocysteine with an increased risk of AMD ( 40, 41).

More research is needed to understand the effectiveness of vitamin B6 in treating anemia in populations other than those at increased risk for B vitamin deficiency, such as pregnant women and older adults Mastrangelo M, Cesario S (November 2019). "Update on the treatment of vitamin B6 dependent epilepsies". Expert Rev Neurother. 19 (11): 1135–47. doi: 10.1080/14737175.2019.1648212. PMID 31340680. S2CID 198496085. Daily Value Reference of the Dietary Supplement Label Database (DSLD)". Dietary Supplement Label Database (DSLD). Archived from the original on 7 April 2020 . Retrieved 16 May 2020. The contradictory results of these studies may be due to the difference in vitamin B6 dose and study length.

a b Schorgg P, Bärnighausen T, Rohrmann S, Cassidy A, Karavasiloglou N, Kühn T (May 2021). "Vitamin B6 Status among Vegetarians: Findings from a Population-Based Survey". Nutrients. 13 (5): 1627. doi: 10.3390/nu13051627. PMC 8150266. PMID 34066199. Question 14—What are the standards and labeling criteria for Foods with Nutrient Function Claims?]. Ministry of Health, Labour, and Welfare (in Japanese) . Retrieved 2021-09-23. ビタミンＢ ６は、たんぱく質からのエネルギー産生と皮膚や粘膜の健康維持を助ける栄養素です。 Transaminases break down amino acids with PLP as a cofactor. The proper activity of these enzymes is crucial for the process of moving amine groups from one amino acid to another. To function as a transaminase coenzyme, PLP bound to a lysine of the enzyme then binds to a free amino acid via formation of a Schiff's base. The process then dissociates the amine group from the amino acid, releasing a keto acid, then transfers the amine group to a different keto acid to create a new amino acid. [3]On the one hand, B6 can decrease high homocysteine blood levels that may increase the risk of Alzheimer’s ( 13, 14, 15). IUPAC-IUB commission on biochemical nomenclature (CBN). Nomenclature for vitamins B-6 and related compounds. Recommendations 1973". European Journal of Biochemistry. 40 (2): 325–327. 1973-12-17. ISSN 0014-2956. PMID 4781383. Overview on Dietary Reference Values for the EU population as derived by the EFSA Panel on Dietetic Products, Nutrition and Allergies" (PDF). 2017. Archived (PDF) from the original on 2017-08-28.