Published data from a large number of studies of women with chronic cocaine abuse during pregnancy are inconsistent in their findings with regard to congenital malformations, prematurity, miscarriage, premature rupture of membranes and gestational hypertension. The applicability of the findings from these studies of chronic abuse in pregnancy to a single topical exposure is limited. Pharmacokinetics of cocaine hydrochloride in patients with reduced plasma cholinesterase activity has not been studied. Deficits in associational learning were reported when pregnant rats were treated with cocaine during gestation (10.3 times the HRD) in the absence of maternal toxicity. Single dose administration of cocaine intravenously during organogenesis in mice produced cryptochidism, anophthalmia, exencephaly, and delayed ossification at 7.8 times the HRD. In rats, a single dose of cocaine administered by intraperitoneal injection produced edematous fetuses, hemorrhages and limb defects at 12.9 times the HRD ( see Data). Epinephrine, Phenylephrine: There have been reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal surgery. Avoid use of additional vasoconstrictor agents with NUMBRINO. If concomitant use is unavoidable, prolonged vital sign and ECG monitoring may be required. ( 5.3, 7.2)

Cocaine has seen both legal and illegal drug use ever since it was discovered. Today, its use is heavily regulated in the United States. History Of The Legal Use Of Cocaine

2. Cocaine Hydrochloride Nasal Solution Dosage and Administration

Adrenaline is believed to enhance the toxic effects of cocaine by further increasing the level of circulating catecholamines. (See Contra-indications) Cocaine Purity Test Kits: If your sample does contain cocaine, this type of drug test kit will let you know how pure the cocaine is. Even high-quality cocaine isn’t going to be 100% pure, but performing this test kit will give you a good indication of whether or not you’re getting ripped off with a substance that contains very little actual cocaine.

The numbing effects of cocaine have been appealing to doctors of the past. Cocaine’s primary medical use has been as an anesthetic. Intravenous cocaine injections were also practiced by doctors. Genetic abnormalities of plasma cholinesterase (e.g., patients who are heterozygous or homozygous for atypical plasma cholinesterase gene), disease conditions such as malignant tumors, severe liver or kidney disease, decompensated heart disease, infections, burns, anemia, peptic ulcer, or myxedema or other physiological states such as pregnancy may lead to reduced plasma cholinesterase activity. Patients with reduced plasma cholinesterase (pseudocholinesterase) activity may have reduced clearance and increased exposure of plasma cocaine after administration of NUMBRINO.The pharmacokinetics of cocaine hydrochloride in patients over the age of 65 has not of been studied. A total of 639 patients were randomized and received a single application of either cocaine hydrochloride nasal solution, 4% (n=258), cocaine hydrochloride nasal solution, 10% (n=254), or placebo (n=127). Sixty-one percent (61%) of randomized patients were female and 81% were white, with a mean age of 38 years (range 18 to 76 years). Patients with a history of myocardial infarction, coronary artery disease, congestive heart failure, irregular heart rhythm, abnormal screening ECG, or uncontrolled hypertension, defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, were excluded from participating in the study. Cholinesterase inhibitors: Concomitant administration may increase the risk of cocaine toxicity. ( 7.4)

Indications from some studies of medicinal cocaine show that death can ensue from 0.8-1.0g (8-10ml of a 10% w/v solution of cocaine).

Over the Internet, at tobacco shops, head shops, gift and novelty shops, gas stations, and convenience stores. Legal consequences

At clinical doses, cocaine has little general toxicity, when applied locally and for a short period of time. Cocaine has one approved medical use in the United States. Cocaine hydrochloride can be used by doctors as a local anesthetic during surgery, especially on the nose, mouth, and throat. Outside of this one use, other forms of cocaine are illicit drugs. While cocaine purity test kits provide a clear picture of product purity, if the purity level is low, they don’t indicate what (besides cocaine) is in it. That’s where cocaine cuts test kits come in. With so many unwanted and potentially dangerous chemicals being used to increase the drug’s weight, as well as enhance its effects, knowing what’s in your product could prevent a nasty experience or even save your life.

16. How is Cocaine Hydrochloride Nasal Solution supplied

Cocaine is minimally metabolized by hydrolysis to ecgonine (minor, inactive metabolite) by carboxylesterase-2.