The debate over the comparison of Subutex and Suboxone mainly focusses on the introduction of the two. Due to the fact that Suboxone was produced after Subutex as a further advancement on methadone, Suboxone is widely argued as the more effective treatment. Similarly to various other opioids, buprenorphine has also been found to act as an agonist of the toll-like receptor 4, albeit with very low affinity. [56] Pharmacokinetics [ edit ] Immediate medical help was needed for people taking Subutex who developed blurred vision, excessive sleepiness, or who became uncoordinated, with slurred speech, slowed reflexes or breathing, or confusion. If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking buprenorphine.

After the medication is fully dissolved, take a large sip of water and swish gently around your teeth and gums, and then swallow the water. This will help to prevent problems with your teeth. Do not brush your teeth for at least one hour after using this medication. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p.528. ISBN 9783527607495. Archived from the original on 10 January 2023 . Retrieved 29 May 2020. Quotas – Conversion Factors for Controlled Substances". Deadiversion.usdoj.gov. Archived from the original on 2 March 2016 . Retrieved 7 November 2016. There is ongoing research as to the validity of these statements and the debate of which of Subutex or Suboxone is more effective. Using Subutex and Suboxone as part of an opioid addiction treatment a b Cote J, Montgomery L (July 2014). "Sublingual buprenorphine as an analgesic in chronic pain: a systematic review". Pain Medicine. 15 (7): 1171–1178. doi: 10.1111/pme.12386. PMID 24995716.

Lemon LS, Caritis SN, Venkataramanan R, Platt RW, Bodnar LM (March 2018). "Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome". Epidemiology. 29 (2): 261–268. doi: 10.1097/EDE.0000000000000780. PMC 5792296. PMID 29112519. Methadone is associated with increased risk of neonatal abstinence syndrome compared with buprenorphine in infants exposed in utero. This association is subject to minimal bias due to unmeasured confounding by severity of addiction. Roth BL, Driscol J. "PDSP K i Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Archived from the original on 29 August 2021 . Retrieved 14 August 2017. Follow your doctor's instructions about how to use this medicine. This is particularly important because buprenorphine can be addictive.

Always remove the old patch before applying a new one. Never apply more than 1 patch at a time, unless your doctor tells you to.Stanciu CN, Glass OM, Penders TM (April 2017). "Use of Buprenorphine in treatment of refractory depression-A review of current literature". Asian Journal of Psychiatry. 26: 94–98. doi: 10.1016/j.ajp.2017.01.015. PMID 28483102.

If you are a driver, please be aware that buprenorphine is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. You should tell the DVLA that you are taking buprenorphine. You are likely to be banned from driving at first, although you should be allowed to drive again later, subject to an annual medical review. Your doctor will tell you when you can resume driving. Baselt R (2008). Disposition of Toxic Drugs and Chemicals in Man (8thed.). Foster City, CA: Biomedical Publications. pp.190–192. ISBN 978-0962652370. Buprenorphine and norbuprenorphine may be quantified in blood or urine to monitor use or non-medical recreational use, confirm a diagnosis of poisoning, or assist in a medicolegal investigation. A significant overlap of drug concentrations exists in body fluids within the possible spectrum of physiological reactions ranging from asymptomatic to comatose. Therefore, having knowledge of both the route of administration of the drug and the level of tolerance to opioids of the individual is critical when results are interpreted. [89] History [ edit ] There is no safe level of drug use. Use of any drug always carries some risk. Even medications can produce unwanted side effects. It’s important to be careful when taking any type of drug.Ling W, Hillhouse MP, Saxon AJ, Mooney LJ, Thomas CM, Ang A, etal. (August 2016). "Buprenorphine + naloxone plus naltrexone for the treatment of cocaine dependence: the Cocaine Use Reduction with Buprenorphine (CURB) study". Addiction. 111 (8): 1416–1427. doi: 10.1111/add.13375. PMC 4940267. PMID 26948856. {{ cite journal}}: CS1 maint: overridden setting ( link) When used correctly, and just as prescribed or instructed by a licensed medical professional, Subutex is far more effective than methadone or other opioid addiction treatment options such as other forms of maintenance therapy. Suboxone Take buprenorphine exactly as your doctor tells you to. Do not take more or less than the dose you have been prescribed. You can take buprenorphine tablets before or after food, but not at the same time. Subutex buccal film for pain relief was usually taken as 75 micrograms (mcg) as a single dose once a day or every 12 hours for at least 4 days. Dosages greater than 900mcg every 12 hours were uncommon.