Brimonidine Tartrate Ophthalmic Solution, 0.15%, NDC numbers 60505-0564-1, 60505-0564-2 and 60505-0564-3. Preservative-free eye drops. This type has fewer additives and is generally recommended if you apply artificial tears more than four times a day, or if you have moderate or severe dry eyes. Preservative-free eye drops may come in single-dose vials. Brand names: Artificial Tears, Biolle Gel Tears, Biolle Tears, GenTeal, Lubricating Plus Eye Drops, Usually, drops may be used as often as needed. Ointments are usually used 1 to 2 times daily as needed. If using an ointment once a day, it may be best to use it at bedtime.

Many times TheraTears Nighttime (carboxymethylcellulose) is used on an as needed basis. Do not use more often than told by the doctor. Eye drops are intended to be sterile, especially due to a heightened risk for infection since they bypass some of the body's natural defenses by being applied directly into the eyes. As of this writing, Kilitch Healthcare India Limited “has not received any reports of adverse events related to this recall,” according to a news release posted by the FDA. If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Clear Eyes Once Daily, Eye Allergy Itch Relief: Lot 114349, Lot 117396, Lot 0120128, Lot 114371, and Lot 123781.Apply 2 drops into each eye, one or more times a day every few hours or otherwise stated by an healthcare professional.

Be sure you know how long you can store TheraTears Nighttime (carboxymethylcellulose) before you need to throw it away.

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October 31, 2023 – La Vergne, TN, The Harvard Drug Group, LLC d/b/a Major® Pharmaceutical and Rugby® Laboratories is initiating a voluntarily recall for all lots of Polyvinyl Alcohol, 1.4% Lubricating Eye Drops and Lubricating Tears Eye Drops (Dextran/Hypromellose, 0.1%/0.3%) supplied by Velocity Pharma, LLC to the consumer level. The Harvard Drug Group, LLC received information from FDA indicating investigator found insanitary conditions in the manufacturing facility and positive bacterial test results from environmental sampling of critical drug production areas in the facility.

Our survey data shows that the currently marketed artificial tears use the following biologically active pharmaceutical excipients and food additives: (a) Osmoprotectants: trehalose, erythritol, levocarnitine, (b) Humectants: sodium hyaluronate, (c) Hydroxypropyl Guar gum, (d) Oils: flaxseed oil, castor oil, mineral oil. You or your doctor can also report adverse events or quality issues to the FDA’s MedWatch Adverse Event Reporting program. As we age it is common to experience dry, tired, and irritated eyes due to the amount of tears our eyes produce naturally reducing. Changes in health conditions, certain medications and hormone balance during and after the menopause can also have an impact on eyes becoming more prone to drying out. Polyvinyl Alcohol, 1.4% Lubricating Eye Drops and Lubricating Tears Eye Drops (Dextran/Hypromellose, 0.1%/0.3%) are available as over the counter (OTC) products used for temporary relief of discomfort due to minor irritations of the eye or to exposure to wind or sun and the product used as a protectant against further irritation or to relieve dryness of the eye.Osmoprotectants are agents that protect cells against hyperosmolar stress-mediated injury. Since hyperosmolarity is one the characteristics of dry eye, osmoprotectants are emerging ingredients of artificial tears. Levocarnitine (L-carnitine) is present in prokaryotic and eukaryotic cells, including human corneal and conjunctival epithelia [ 11, 12]. Erythritol is polyol used as a low-calorie sweetener. In vitro studies using cultured human corneal epithelial cells demonstrate that osmoprotectants are taken up by the dehydrated cells, then restore volume and prevent protein denaturation [ 13, 14]. Trehalose is a naturally occurring disaccharide consisting of two alpha-glucose units joined by glucoside bond. Trehalose has also been shown to protect corneal epithelial cells from desiccation and high osmolarity [ 15, 16, 17]. Our data analysis demonstrated that erythritol, L-carnitine, and trehalose are present in some Refresh ® brand artificial tears, which contain CMC as the main demulcent ( Table 1).