We found that red light treatment reduced the severity, but not the incidence of hypersensitivity at 7days post-injury. As allodynia reached sensitivity levels of almost four times that of the hypersensitivity threshold, we would expect that a milder injury causing sensitivity scores closer to the hypersensitivity threshold boarder would result in a reduction of both the severity and incidence of hypersensitivity. The finding that the shamSCI+670 group demonstrated sensitivity significantly lower than that of the intact control and shamSCI groups was curious. Sham injury may have activated anti-nociceptive descending pathways such as periaqueductal grey/raphe magnus-mediated inhibition of dorsal horn nociceptive inputs [ 49]. Thus, endogenous central anti-nociceptive mechanisms, compounded by a red light-induced anti-inflammatory microenvironment, could be responsible for the sham-injured-light-treated animals expressing less sensitivity than observed in uninjured animals. This speculation warrants further investigation as red light-augmented relief from pain would have significant clinical relevance for post-surgical pain treatment. En fait, les conduites sensori-motrices sont toujours présentes dans le comportement humain. Leur place et leur importance varient suivant les tâches dans lesquelles le sujet est engagé. Microglia/macrophages can adopt pro- or anti-inflammatory states [ 30]. To determine the effect of red light treatment on the expression of pro-inflammatory (M1) cells, cells co-expressing CD80 and ED1 were quantified as a proportion of total ED1 + cells (Fig. 6e– h, n=5 for each time point). The proportion of CD80 +ED1 + cells ipsilateral to the injury was maximal at day 1 and remained greater than 40% of the ED1 population at days 3 and 7 in more than half of animals. CD80 +ED1 + cells were only found at day 3 on the contralateral side which coincided with the maximum number of ED1 + cells at that time point. Red light treatment did not have a significant impact on the proportion of M1 cells on either the ipsi- or contralateral sides. Note that no CD80 +ED1 + cells were encountered at days 1 and 7 contralateral to the injury as ED1 + cells were also in small quantities at these time points (Fig. 6a).

MARCH 24, 2023 - FEBRUARY 4, 2024 Eastern Time Zone. Level 2: Psychotherapie Sensorimotrice pour le traitement des blessures developpementales L'exploration sensorimotrice est un mécanisme fondamental du développement des systèmes biologiques.NOVEMBER 30, 2023 - MAY 23, 2024 Espana (Online). Level 1: Psicoterapia Sensoriomotriz para el tratamiento del trauma - (online)

Ils sont en outre en mesure, tout comme les handicapés mentaux sévères, d'agir au niveau de la régulation sensorimotrice. To our knowledge, our study is the first to report a red light-induced locomotor improvement following a spinal cord injury, which contradicts the only other study by Giacci et al. [ 9] that examined 670nm on locomotor recovery with a daily dose of 28.4J/cm 2, an intensity of 15.8mW/cm 2 for 30min, i.e. less than half the intensity of the present study. The compounded effect of reduced intensity and a more severe contusion injury in their study may explain this difference, and furthermore, suggests that matching the appropriate light dosage to the injury severity is of paramount importance. APRIL 21, 2023 - DECEMBER 17, 2023 Milano, Italy. Level 2: La Psicoterapia Sensomotoria per le ferite Relazionali e dello Sviluppo University of Newcastle School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, Hunter Medical Research Institute, Australia; NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Australia.

Acknowledgments

MAY 3, 2023 - MAY 12, 2024 Seoul, South Korea. Level 2: Sensorimotor Psychotherapy for Developmental & Relational Injury La motricité est modulable, souple, adaptable en fonction de l’environnement. Les modules sensori-moteur relient les informations sensorielles et motrices entre elles, sortes d’outils permettant au bébé d’apprendre et d’expérimenter sur l’environnement.

Figure 2. Scatterplots (A,B) and Bland-Altman plots (C,D) for comparison of the point-of-care nerve conduction method versus standard NCS for SNAP or SNCV. Shamoon H, Fleischer N, Engl S, Al E (1993) The Effect Of Intensive Treatment Of Diabetes On The Development And Progression Of Long-Term Complications In Insulin-Dependent Diabetes Mellitus. The New England Journal Of Medicine 329: 977–986. NOVEMBER 17, 2023 - SEPTEMBER 15, 2024 Mountain Time Zone. Level 2: Sensorimotor Psychotherapy for Developmental & Relational Injury - Online Our T10 hemicontusion injury model resulted in allodynia within 7days in a subset of animals. We are confident that our injury model results in neuropathic pain because hypersensitivity developed above and below the level, as well as contralateral to the injury, i.e. at dermatomes that receive their innervation from outside the injury epicentre. This observation is also consistent with findings from an investigation using a C5 hemicontusion injury model and which also found a subset of animals developing allodynia from 7days post-injury that lasted for least 42days [ 47]. Our observation of allodynia on the animals’ dorsum is also consistent with a T13 hemisection injury model that also results in clear development of hypersensitivity in most animals within 7days and that remains persists for several weeks [ 48].We demonstrate that following spinal cord injury, 35mW/cm 2 of red (670nm) light transcutaneously applied for 30min/day for 7days to the dorsal surface of rats is sufficient to reach the entire spinal cord and reduce the expression of pain behaviours. These reduced signs of allodynia are not due to sensorimotor deficits, as red light treatment improves both sensory and motor function. Alleviated hypersensitivity, improved tactile/proprioception (dorsal column) pathway functional integrity and locomotor functional outcomes are preceded by reduced numbers of dying cells and reduced numbers of activated microglia/macrophages around the injury zone. Furthermore, the proportion of anti-inflammatory/wound-healing (M2) microglia/macrophages is greatly enhanced by 24h following light treatment. NOVEMBER 25, 2024 - NOVEMBER 8, 2025 Bordeaux, France. Level 2: Psychotherapie Sensorimotrice pour le traitement des blessures developpementales Cette différence de réactivité sensorimotrice alpha a été réduite au cours de la stimulation SMTr active. Bland J, Altman D (2010) Statistical Methods For Assessing Agreement Between Two Methods Of Clinical Measurement. International Journal Of Nursing Studies 47: 931–936.

L’approche douce de l’intégration sensorielle et motrice peut apporter plusieurs avantages pour les enfants en difficulté : Furthermore, like people with severe mentally disabilities, they may act at the level of sensory-motor control. Panels A and B: Scatterplot of SNAP (A) and SNCV (B) showing the line of unity (diagonal solid line) between the two methods. Panels C and D: The Bland-Altman plots demonstrating the mean difference (depicted by the solid line) between SNAP (C) or SNCV (D) obtained by the two methods. Points above or below zero on the y-axis represent over- and underestimation by the point-of-care device, respectively. The dotted lines represent the upper and lower limits of the 85% confidence interval. Unrecordable SNCV results for both nerve conduction methods were assigned a value of 30.4 m/s, representing the lowest value in the dataset. Such data handling was applied to 9 values for standard NCS and 3 values for the point-of-care device. Esperanza H, Camargo D, Delgado D, Salvini T (2009) Reliability Of Superficial Peroneal, Sural, And Medial Plantar Nerve Conduction Studies: Analysis Of Statistical Methods. Journal Of Clinical Neurophysiology 26: 372–379.Les dysfonctionnements de l’intégration sensorielle et motrice peuvent avoir des conséquences sur le comportement des enfants, tels que :