Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B Association of vitamin D status with serum androgen levels in men Clin Endocrinol (Oxf). (2010 Aug) Added sweeteners: Zinc lozenges are often made with a sweetener, whether that is corn syrup or sucrose, so take that into consideration if you are concerned about your sugar intake.

FoodData Central Search Results U.S. Department of Agriculture, Agricultural Research Service. (2023) Brilla et al Effects of a Novel Zinc-Magnesium Formulation on Hormones and Strength Journal of Exercise Physiology. (2020) Vreugdenhil M, Akkermans MD, van der Merwe LF, van Elburg RM, van Goudoever JB, Brus F Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries. Nutrients. (2021-Oct-22)

Sperm health: If starting a family is on your to-do list, zinc might be a supplement that you, or your male partner, will want to consider for maximum sperm health. According to Mannaker, “sperm is extremely susceptible to cell damage, which can be a result of a variety of things, including being exposed to pollution, eating fried foods frequently, and living a stressful lifestyle.” Zinc acts as an antioxidant, helping support sperm health and reducing the risk of damage. Tinnitus Symptoms - Arda HN, Tuncel U, Akdogan O, Ozluoglu LN The role of zinc in the treatment of tinnitus Otol Neurotol. (2003 Jan)

Uwitonze AM, Razzaque MS Role of Magnesium in Vitamin D Activation and Function J Am Osteopath Assoc. (2018 Mar 1) Insulin - Hashemipour M, Kelishadi R, Shapouri J, Sarrafzadegan N, Amini M, Tavakoli N, Movahedian-Attar A, Mirmoghtadaee P, Poursafa P Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children Hormones (Athens). (2009 Oct-Dec) Acne Symptoms - Brittany E Yee, Phillip Richards, Jennifer Y Sui, Amanda Fleming Marsch Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis Dermatol Ther. (2020 Aug 29) Subjective Well-Being - Stewart-Knox BJ, Rae G, Simpson EE, McConville C, O'Connor J, Polito A, Andriollo-Sanchez M, Coudray C, Strain JJ Supplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith study Public Health Nutr. (2011 May) Camacho EM, Huhtaniemi IT, O'Neill TW, Finn JD, Pye SR, Lee DM, Tajar A, Bartfai G, Boonen S, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Keevil B, Lean ME, Pendleton N, Punab M, Vanderschueren D, Wu FC, EMAS Group Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study Eur J Endocrinol. (2013 Feb 20)

Rationale

Anti-Oxidant Enzyme Profile - Kara E, Gunay M, Cicioglu I, Ozal M, Kilic M, Mogulkoc R, Baltaci AK Effect of zinc supplementation on antioxidant activity in young wrestlers Biol Trace Elem Res. (2010 Apr) In treated patients, assays of urinary and/or plasma zinc may be a useful measure of treatment compliance. Values of urinary zinc above 2 mg/24 h and of plasma zinc above 1250 microgram/l generally indicate adequate compliance. Parva NR, Tadepalli S, Singh P, et al. Prevalence of vitamin D deficiency and associated risk factors in the US population (2011-2012). Cureus. 2018;10(6):e2741. doi:10.7759/cureus.2741

Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. Dording CM, Schettler PJ, Dalton ED, Parkin SR, Walker RS, Fehling KB, Fava M, Mischoulon D A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women Evid Based Complement Alternat Med. (2015) Zinc acetate dihydrate is not recommended for the initial therapy of symptomatic patients because of its slow onset of action. Symptomatic patients must be initially treated with a chelating agent; once copper levels are below toxic thresholds and patients are clinically stable, maintenance treatment with Wilzin can be considered. Pneumonia Symptoms - Valavi E, Hakimzadeh M, Shamsizadeh A, Aminzadeh M, Alghasi A The efficacy of zinc supplementation on outcome of children with severe pneumonia. A randomized double-blind placebo-controlled clinical trial Indian J Pediatr. (2011 Sep)

Appointments at Mayo Clinic

Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Washington (DC) Nutritional Needs in Hot Environments, “Influence of Exercise and Heat on Magnesium Metabolism” National Academies Press (US). (1993) One of the forms most commonly used for cold-related products and shown to be effective at reducing symptoms. Tang YM, Wang DG, Li J, Li XH, Wang Q, Liu N, Liu WT, Li YX Relationships between micronutrient losses in sweat and blood pressure among heat-exposed steelworkers Ind Health. (2016 Jun 10) Zinc oxide (80%) (FamilyPractice). Although the percentage of elemental zinc is high, do take note that zinc oxide is one of the least bioavailable form.

Pneumonia Symptoms - Shah GS, Dutta AK, Shah D, Mishra OP Role of zinc in severe pneumonia: a randomized double bind placebo controlled study Ital J Pediatr. (2012 Aug 2) If you are taking certain medications, it’s important that you speak with a healthcare provider before considering taking a zinc supplement. Grossmann M, Matsumoto AM A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management J Clin Endocrinol Metab. (2017 Mar 1) Heaney R, Garland C, Baggerly C, French C, Gorham E Letter to Veugelers, P.J. and Ekwaru, J.P., A statistical error in the estimation of the recommended dietary allowance for vitamin D. Nutrients 2014, 6, 4472-4475; doi:10.3390/nu6104472 Nutrients. (2015 Mar 10)Palsa Kondaiah, Puneeta Singh Yaduvanshi, Paul A Sharp, Raghu Pullakhandam Iron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption? Nutrients. (2019 Aug 13)