Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J, Sun G. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. doi:10.1016/j.jep.2014.09.049

Chan M, Qin Z, Man SC, et al. Adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia: a randomized controlled trial. Psychiatry Clin Neurosci 2022;76(3):77-85. View abstract. Ozaki, Y., Suzuki, H., and Satake, M. [Comparative studies on concentration of berberine in plasma after oral administration of coptidis rhizoma extract, its cultured cells extract, and combined use of these extracts and glycyrrhizae radix extract in rats]. Yakugaku Zasshi 1993;113(1):63-69. View abstract. Cicero, AF, Rovati LC, and Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation. Arzneimittelforschung. 2007;57:26-30. View abstract. Chen XX, Chen YX, Bi HX, et al. Efficacy and safety of triple therapy containing berberine hydrochloride, amoxicillin, and rabeprazole in the eradication of Helicobacter pylori. J Dig Dis 2022;23(10):568-76. View abstract.

Suggested Alternative Products

Did the capsules have a clean, simple ingredient design, or were they bloated with silica and other binders or coloring agents? The dosage of berberine in this supplement (600 mg per capsule) is middle-of-the-road, but its simplistic design and its allergen-free certification make it a very solid choice. Berberine is fairly safe, with mild gastrointestinal side effects like constipation and stomach pain occasionally reported. Berberine appears to be most effective when taken at dosage levels of 900 to 1500 mg per day, split into two to three equal doses. Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., Wang, S., Wu, J., Wang, Y., Li, Z., Liu, J., and Jiang, J. D. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 2004;10(12):1344-1351. View abstract.

It also lowered hemoglobin A1c (HbA1c), a marker of long-term blood sugar regulation, by 12% and improved levels of blood lipids such as cholesterol and triglycerides ( 11).Huang CG, Chu ZL, Wei SJ, Jiang H, Jiao BH. Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. Thromb Res 2002;106(4-5):223-7. View abstract. Oxidative stress and inflammation: It has been shown to have potent antioxidant and anti-inflammatory effects in some test-tube and animal studies ( 25, 26, 27).

Arana, B. A., Navin, T. R., Arana, F. E., Berman, J. D., and Rosenkaimer, F. Efficacy of a short course (10 days) of high-dose meglumine antimonate with or without interferon-gamma in treating cutaneous leishmaniasis in Guatemala. Clin Infect Dis 1994;18(3):381-384. View abstract. Subbaiah TV and Amin AH. Effect of berberine sulphate on Entamoeba histolytica. Nature 1967;215(100):527-528. Suadoni MT, Atherton I. Berberine for the treatment of hypertension: a systematic review. Complement Ther Clin Pract. 2021;42:101287. doi:10.1016/j.ctcp.2020.101287 Shaffer, J. E. Inotropic and chronotropic activity of berberine on isolated guinea pig atria. J Cardiovasc Pharmacol 1985;7(2):307-315. View abstract. Mohan, M., Pant, C. R., Angra, S. K., and Mahajan, V. M. Berberine in trachoma. (A clinical trial). Indian J Ophthalmol. 1982;30(2):69-75. View abstract.Berberine appears to modulate the way your body processes and uses energy. That means berberine supplements are tailored for a few specific use cases: Berberine’s specialized uses informed our ranking procedure: since there are several clinical trials on using berberine, we were able to compare the delivery mechanism, dosage, and purity of the products we considered to the gold standard of what’s used in scientific research. Specifically, we looked for: Kim SH, Shin DS, Oh MN, et al. Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biosci Biotechnol Biochem 2004;68:421-4.. View abstract. Pérez-Rubio KG, González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, Espinel-Bermúdez MC. Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metab Syndr Relat Disord 2013;11(5):366-9. View abstract. Seery TM and Bieter RN. A contribution to the pharmacology of berberine. J Pharmacol Exp Ther 1940;69:64-67.