Pharmacotherapeutic group: Anti-inflammatory and antirheumatic products, nonsteroidal; propionic acid derivatives. The lowest effective dose should be used for the shortest duration necessary to relieve symptoms (see section 4.4).

Peptic ulcers, perforation or gastrointestinal bleeding, sometimes fatal, particularly in the elderly may occur (see section 4.4). Nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, gastrointestinal haemorrhage and exacerbation of colitis and Crohn's disease (see section 4.4) have been reported following ibuprofen administration. Less frequently, gastritis, duodenal ulcer, gastric ulcer and gastrointestinal perforation have been observed. Brufen should be given with care to patients with a history of heart failure or hypertension since oedema has been reported in association with ibuprofen administration. Your doctor will try to prescribe you the lowest dose for the shortest time to reduce the risk of side-effects. If you need to take ibuprofen for a long time, your doctor may want to prescribe another medicine along with it to protect your stomach from irritation. If you have bought ibuprofen 'over the counter', take it as a short course of treatment - you should stop taking it once the painfulness or the high temperature (fever) has gone.The concomitant consumption of excessive alcohol with NSAIDs, including ibuprofen, may increase the risk of adverse effects on the gastrointestinal tract, such as GI haemorrhage or the central nervous system possibly due to the additive effect.

Aminoglycosides : NSAIDs may decrease the excretion of aminoglycosides. Herbal extracts : Ginkgo biloba may potentiate the risk of bleeding with NSAIDs. CYP2C9 Inhibitors : Concomitant administration of ibuprofen with CYP2C9 A transient sensation of burning in the mouth or throat may occur with Ibuprofen 100mg/5ml Oral Suspension. Possible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses; Anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs): Increased risk of gastrointestinal bleeding with NSAIDs (see section 4.4).Quinolone antibiotics : Animal data indicate that NSAIDs can increase the risk of convulsions associated with quinolone antibiotics. Patients taking NSAIDs and quinolones may have an increased risk of developing convulsions.

NSAIDs should be given with care to patients with a history of ulcerative colitis or Crohn's disease as these conditions may be exacerbated (see section 4.8 Undesirable effects). If a doctor prescribes tablets or capsules for children aged under 12 years, they will use your child's age and weight to work out the right dose for them. During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the foetus to the following: Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs (see section 4.8). Patients appear to be at highest risk of these reactions early in the course of therapy, the onset of the reaction occurring within the first month of treatment in the majority of cases. Acute generalised exanthematous pustulosis (AGEP) has been reported in relation to ibuprofen-containing products. Ibuprofen should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.

Cholestyramine: The concomitant administration of ibuprofen and cholestyramine may reduce the absorption of ibuprofen in the gastrointestinal tract. However, the clinical significance is unknown. Each ibuprofen tablet or capsule contains 200mg, 400mg or 600mg of ibuprofen. Slow-release tablets and capsules contain 200mg, 300mg or 800mg of ibuprofen. Quinolone antibiotics: Animal data indicate that NSAIDs can increase the risk of convulsions associated with quinolone antibiotics. Patients taking NSAIDs and quinolone may have increased risk of developing convulsions. Ibuprofen, like other NSAIDs, can interfere with platelet aggregation and prolong bleeding time in normal subjects.