Egert, S., Wolffram, S., Bosy-Westphal, A., Boesch-Saadatmandi, C., Wagner, A. E., Frank, J., Rimbach, G., and Mueller, M. J. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 2008;138(9):1615-1621. View abstract. Kressler J, et al. (2011). Quercetin and endurance exercise capacity: a systematic review and meta-analysis. Knab AM, Shanely RA, Jin F, Austin MD, Sha W, Nieman DC. Quercetin with vitamin C and niacin does not affect body mass or composition. Appl Physiol Nutr Metab. 2011;36(3):331-8. View abstract.

Saeedi-boroujeni, A., et al. (2021). Anti-inflammatory potential of Quercetin in COVID-19 treatment. Naturally occurring quercetin derivatives: isorhamnetin (3-methyl ether of quercetin) quercitrin (quercetin 3- O-rhamnoside), isoquercitrin (quercetin 3- O-glucoside), quercetin 7- O-rhamnoside, hyperoside (quercetin 3- O-galactoside), rutin/rutoside (quercetin 3- O-rhamnozyl-(1 → 6)-glucoside).Unfortunately, to date, there are no effective methods that would inhibit neurodegenerative changes of dopaminergic neurons. Available pharmacotherapy is based on supplying dopamine precursors or on stimulation of dopamine synthesis in the remaining neurons. A couple of studies reported a beneficial effect of Que on motor dysfunctions in PD models. The administration of Que at a dose of 30 mg/kg in 6-hydroxydopamine (6-OHDA)-intoxicated rats for 14 consecutive days resulted in amelioration in the striatal dopamine and antioxidant enzyme levels in comparison with a PD-induced control. Additionally, there were fewer dead neurons observed in the Que-treated group. In another experiment, Que doses of 100 and 200 mg/kg, but not 50 mg/kg, given p.o. for 14 consecutive days alleviated significantly motor balance and coordination in the rotarod test in mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD [ 85]. Nguyen MA, Staubach P, Wolffram S, Langguth P. Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans - Implications for the evaluation of transporter-mediated flavonoid-drug interactions. Eur J Pharm Sci 2014;61:54-60. View abstract.

Kuwabara M, Yoon C, Goyne T, Thederahn T, Sigman DS (1986) Nuclease activity of 1, 10-phenanthroline-copper ion: reaction with CGCGAATTCGCG and its complexes with netropsin and EcoRI. Biochemistry 25(23):7401–7408 Diet plays an essential role in reducing the risk of cardiovascular diseases, such as heart disease and strokes. Because fruit and vegetables contain flavonoids, eating more may help reduce the risk of these diseases. Starvic B. Quercetin in our diet: from potent mutagen to probable anticarcinogen. Clin Biochem 1994;27:245-8.Otsuka H, Inaba M, Fujikura T, Kunitomo M. Histochemical and functional characteristics of metachromatic cells in the nasal epithelium in allergic rhinitis: studies of nasal scrapings and their dispersed cells. J Allergy Clin Immunol 1995;96:528-36.. View abstract. According to a 2019 review of studies, published in Phytotherapy Research, taking 500mg or more of quercetin daily for at least eight weeks reduced blood glucose levels in people with metabolic syndrome. Selvaraj S, Krishnaswamy S, Devashya V, Sethuraman S, Krishnan UM (2012) Synthesis, characterization and DNA binding properties of rutin–iron complex. RSC Adv 2(7):2797–2802 Monica Leopoldini NR, Sandro C, Marisosa T (2006) Iron chelation by the powerful antioxidant flavonoid quercetin. J Agric Food Chem 54:6343–6351 Nishimura, M., et al. (2020). Effect of daily ingestion of quercetin-rich onion powder for 12 weeks on visceral fat: A randomised, double-blind, placebo-controlled, parallel-group